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Motor neuron and pancreas homeobox 1

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, fibrillin-1, Isl-1
Papers using HB9 antibodies
Targeting genes for self-excision in the germ line
Schieren Ira et al., In Neural Development, 1998
... HB9::eGFP transgenic animals [ ...
Papers on HB9
Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).
Agarwal et al., Bethesda, United States. In J Biol Chem, Nov 2015
Such tumors express the phosphorylated isoform of the β-cell differentiation transcription factor HLXB9.
Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique.
Haase et al., Paris, France. In Neurobiol Dis, Oct 2015
Here, we succeeded in isolating 100% pure and standardized human motor neurons by a novel FACS double selection based on a p75(NTR) surface epitope and an HB9::RFP lentivirus reporter.
Induction of human umbilical Wharton's jelly-derived mesenchymal stem cells toward motor neuron-like cells.
Joghataei et al., Tehrān, Iran. In In Vitro Cell Dev Biol Anim, Oct 2015
Differentiated neurons were then characterized for expression of motor neuron markers including nestin, PAX6, NF-H, Islet 1, HB9, and choline acetyl transferase (ChAT) by quantitative reverse transcription PCR and immunocytochemistry.
Comparison of Capability of Human Bone Marrow Mesenchymal Stem Cells and Endometrial Stem Cells to Differentiate into Motor Neurons on Electrospun Poly(ε-caprolactone) Scaffold.
Ai et al., Tehrān, Iran. In Mol Neurobiol, Oct 2015
Engineered hBM-MSCs and hEnSCs seeded on PCL nanofibrous scaffold were differentiated into beta-tubulin III, islet-1, Neurofilament-H (NF-H), HB9, Pax6, and choactase-positive motor neurons by immunostaining and real-time PCR, in response to the signaling molecules.
Neuronal labeling patterns in the spinal cord of adult transgenic Zebrafish.
Drapeau et al., Montréal, Canada. In Dev Neurobiol, Oct 2015
We used well-known transgenic lines in which expression of green fluorescent protein (GFP) is driven by promoters to hb9 and isl1 in motoneurons, alx/chx10 and evx1 interneurons, ngn1 in sensory neurons and olig2 in oligodendrocytes, as well as antibodies for neurons (HuC/D, NF and SV2) and glia (GFAP).
Neurogenic potential of spinal cord organotypic culture.
Murashov et al., Greenville, United States. In Neurosci Lett, Jun 2015
Immunostaining for HB9 and Lim2 revealed subsequent differentiation of MAP2-positive cells into motor neurons and interneurons, respectively.
Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells.
Okada et al., Japan. In Mol Brain, 2014
Treatment with GSK3β inhibitors during the initial phase of differentiation in combination with dual SMAD inhibition was sufficient to induce PAX6 (+) and SOX1 (+) neural progenitors within 1 week, and subsequent treatment with retinoic acid (RA) and purmorphamine, which activates sonic hedgehog (SHH) signaling, resulted in the highly efficient induction of HB9(+) and ISL-1(+) motor neurons within 2 weeks.
[ALS disease modeling and drug screening using patient-specific iPS cells].
Inoue et al., Kyoto, Japan. In Rinsho Shinkeigaku, 2012
Disease-specific iPSCs were differentiated into MNs expressing HB9 and SMI-32.
Novel mutations in the MNX1 gene in two families with Currarino syndrome and variable phenotype.
Nordenskjöld et al., Stockholm, Sweden. In Gene, 2012
two novel mutations in the MNX1 gene in cases with Currarino syndrome
Lentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons.
Bendotti et al., Milano, Italy. In J Neurosci Methods, 2012
we developed recombinant lentiviral vectors carrying motor neuron specific regulatory sequences derived from the promoter of homeobox gene Hb9
RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors.
Grapin-Botton et al., Lausanne, Switzerland. In Mol Cell Biol, 2012
Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of Ptf1a and is regulated by a distant enhancer element.
Therapeutic potential of motor neurons differentiated from embryonic stem cells and induced pluripotent stem cells.
Velasco et al., Mexico. In Arch Med Res, 2012
Differentiated MN express characteristic molecular markers such as Islet1, HB9 and Choline acetyltransferase, exhibit electrophysiological maturity and are able to form synaptic contacts similar to neuromuscular junctions in vitro.
Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas.
Prince et al., Chicago, United States. In Development, 2011
Data suggest that Mnx1 functions to promote beta and suppress alpha cell fates in the developing pancreas.
Mutation analysis of the motor neuron and pancreas homeobox 1 (MNX1, former HLXB9) gene in Swedish patients with Currarino syndrome.
Nordenskjöld et al., Stockholm, Sweden. In J Pediatr Surg, 2011
2 previously described mutations, 1 de novo nonsense mutation (p.Gln212X) & 1 maternally inherited frameshift mutation (p.Pro18ProfsX38)were found among 14 Currarino syndrome patients with presacral tumors.
Autosomal-dominant non-syndromic anal atresia: sequencing of candidate genes, array-based molecular karyotyping, and review of the literature.
Ludwig et al., Bonn, Germany. In Eur J Pediatr, 2011
In addition, sequence analysis of four major Hirschsprung's disease genes (RET, EDNRB, EDN3, and GDNF) and the HLXB9 gene was performed to identify a mutation common to all three family members; however, these analyses did not reveal any causal genetic alteration.
Neonatal and late-onset diabetes mellitus caused by failure of pancreatic development: report of 4 more cases and a review of the literature.
Marsh et al., London, United Kingdom. In Pediatrics, 2008
These genes include Pdx1, the master regulator of pancreas development and beta-cell differentiation, and other transcription factors that are expressed early in pancreas development, namely, Ptf1a, Sox9, Sox17, Hnf6, and HlxB9.
Specification of motoneurons from human embryonic stem cells.
Zhang et al., In Nat Biotechnol, 2005
The in vitro-generated motoneurons expressed HB9, HoxC8, choline acetyltransferase and vesicular acetylcholine transporter, induced clustering of acetylcholine receptors in myotubes, and were electrophysiologically active.
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p.
Rival et al., Nantes, France. In Prenat Diagn, 2004
FISH analysis demonstrated haploinsufficiency of HLXB9, a gene identified in the triad of a presacral mass (teratoma or anterior meningocele), sacral agenesis, and anorectal malformation, which constitutes the Currarino syndrome.
Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice.
Kehrl et al., Bethesda, United States. In Nat Genet, 1999
The homeobox gene HLXB9 (encoding HB9) is prominently expressed in adult human pancreas, although its role in pancreas development and function is unknown.
A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis.
Strachan et al., Newcastle upon Tyne, United Kingdom. In Nat Genet, 1998
We excluded several candidate genes before identifying patient-specific mutations in a homeobox gene, HLXB9, which was previously reported to map to 1q41-q42.1 and to be expressed in lymphoid and pancreatic tissues.
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