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Keratin 84

Hb4
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, Hb3, HB-5, HAD
Papers on Hb4
Is There a Relationship Between Bell's Palsy and Internal Auditory Canal?
New
Sanli et al., İstanbul, Turkey. In Indian J Otolaryngol Head Neck Surg, Sep 2015
Initial House-Brackmann (HB) score was HB-2 in 29 patients (45.3 %), HB-3 in 18 patients (28.1 %), HB-4 in 13 patients (20.3 %) and HB-5 in 4 patients (6.2 %).
Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.
New
Levin et al., Medford, United States. In J Neurosci, Apr 2015
The hyperpolarization signal also synergizes with canonical reprogramming factors (POU and HB4), directing undifferentiated cells toward neural fate in vivo.
Stitchless fibrin glue-aided facial nerve grafting after cerebellopontine angle schwannoma removal: technique and results in 15 cases.
New
Darrouzet et al., Recife, Brazil. In Otol Neurotol, Mar 2015
FN recovery was HB3 in 13 cases (86.7%) and HB4 in 2. The mean time to the first clinical signs of facial reinnervation was 10 months (6-12 mo).
Determination of organ-specific anemia tolerance.
Meier et al., Tübingen, Germany. In Crit Care Med, 2013
INTERVENTIONS: Animals were anesthetized, ventilated, and randomized into three groups and then hemodiluted by exchange of 6% hydroxyethyl starch (130,000:0.4) for whole blood to the group-specific endpoint: Sham (no hemodilution), Hb4 (hemoglobin 4.3 g/dL), Hbcrit (2.7 g/dL).
Screening citrullinated proteins in synovial tissues of rheumatoid arthritis using 2-dimensional western blotting.
Yan et al., China. In J Rheumatol, 2013
RESULTS: RA sera and the anticitrulline antibody on 2-D WB detected α-1-antitrypsin (A1AT), dynein heavy-chain 3, fibrinogen β chain, keratin type II cuticular Hb4 (KRT84), lumican, tubulin β-chain (TUBB), and vimentin.
Turn-directed α-β conformational transition of α-syn12 peptide at different pH revealed by unbiased molecular dynamics simulations.
Cao et al., Dezhou, China. In Int J Mol Sci, 2012
Turn9-6 and four hydrogen bonds (HB9-6, HB6-9, HB11-4 and HB4-11) are formed at physiological pH; turn8-5 and five hydrogen bonds (HB8-5, HB5-8, HB10-3, HB3-10 and HB12-1) are formed at acidic pH.
Transcriptional profiling of genes involved in embryogenic, non-embryogenic calluses and somatic embryogenesis of Valencia sweet orange by SSH-based microarray.
Guo et al., Wuhan, China. In Planta, 2012
Some new transcription factors associated with citrus SE, like a B3 domain containing gene and HB4, were identified.
Adaptive haemoglobin gene control in Daphnia pulex at different oxygen and temperature conditions.
Paul et al., Münster, Germany. In Comp Biochem Physiol A Mol Integr Physiol, 2011
Several subunits (Hb4, Hb7, Hb8, and Hb10) were obviously responsible for changes in oxygen affinity including those, which carry a number of hypoxia-responsive elements (HREs) upstream of the respective gene (hb4 and hb10).
Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases.
Nordmann et al., Amiens, France. In Antimicrob Agents Chemother, 2010
The ampC genes encoding the five pAmpCs and the chromosomal AmpC of Escherichia coli EC6, which was used as a reference cephalosporinase, were cloned and introduced into wild-type E. coli TOP10 and OmpC/OmpF porin-deficient E. coli HB4 strains.
Halobacillus profundi sp. nov. and Halobacillus kuroshimensis sp. nov., moderately halophilic bacteria isolated from a deep-sea methane cold seep.
Naganuma et al., Hiroshima, Japan. In Int J Syst Evol Microbiol, 2007
These bacteria, strains IS-Hb4(T) and IS-Hb7(T), were spore-forming and non-motile.
Isomers of the uracil dimer: an ab initio benchmark study.
Leutwyler et al., Bern, Switzerland. In J Phys Chem B, 2007
The most stable isomer is the doubly N1-H...O hydrogen-bonded HB4 form, with D(e)[CCSD(T)]= -19.04 kcal/mol.
Linear 3-hydroxybutyrate tetramer (HB4) produced by Sphingomonas sp. is characterized as a growth promoting factor for some rhizomicrofloral composers.
Tahara et al., Sapporo, Japan. In Biosci Biotechnol Biochem, 2006
This factor was successfully isolated and identified as linear (R,R,R,R)-3-hydroxybutyrate tetramer (HB4), having a hydroxy-end and a carboxy-end group.
Effect of blood transfusion on survival among children in a Kenyan hospital.
Impact
Were et al., Atlanta, United States. In Lancet, 1992
Children with Hb4.7 g/dl and respiratory distress who had received a blood transfusion had a lower mortality rate than those who did not receive a blood transfusion (OR=0.19).
The Bohr effect of the blood in rainbow trout (Salmo gairdnerii). A comparative study with human blood, using precise oxygen equilibrium curves and the Adair model.
Vorger, Grenoble, France. In Comp Biochem Physiol A Comp Physiol, 1984
7. The data attribute a major role to Hb4 in trout blood isotherms and confirm the importance of the C-termini of Beta chains in Bohr and Root effects.
A comparative analysis of biparental mating and selfing in pearl millet (Pennisetum typhoïdes) S & H : I. Nature of variation and changes in association.
Murty et al., New Delhi, India. In Theor Appl Genet, 1973
Comparison of means and variances within and between the two groups of progenies (A and T-series) and with those of released hybrids (HB-1, HB-2, HB-3, HB-4) for seventeen characters (six related to development, six to productivity, three to vegetative growth and one each to earliness and disease incidence) showed significant variation among the lines of the two series for synchrony of tillering, earliness, disease incidence, chlorophyll depth, grain hairiness, tiller number, plant height, length of earhead, grain yield and grain weight.
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