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Keratin 83

Hb3, hHb3, K83
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAIR, cytokeratin, hHb1
Papers on Hb3
Is There a Relationship Between Bell's Palsy and Internal Auditory Canal?
New
Sanli et al., İstanbul, Turkey. In Indian J Otolaryngol Head Neck Surg, Sep 2015
Initial House-Brackmann (HB) score was HB-2 in 29 patients (45.3 %), HB-3 in 18 patients (28.1 %), HB-4 in 13 patients (20.3 %) and HB-5 in 4 patients (6.2 %).
Seroprevalence and evolutionary dynamics of genotype 4 hepatitis E virus in Shandong Province, China.
Li et al., Tianjin, China. In World J Gastroenterol, 2014
The isolate CH-YT-HEV01 was close to HB-3 and CHN-SD-sHEV with a bootstrap value of 100%, sharing a 96.1%-96.4% identity with each other.
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
Impact
Verdin et al., Novato, United States. In Cell Metab, 2014
Finally, mutation of hypersuccinylated residues K83 and K310 on HMGCS2 to glutamic acid strongly inhibits enzymatic activity.
Rice (Oryza) hemoglobins.
Review
Sarath et al., Ecatepec, Mexico. In F1000res, 2013
At the molecular level, a family of the nshb genes, consisting of hb1, hb2, hb3, hb4 and hb5, and a single copy of the thb gene exist in Oryza sativa var.
Transcriptome alteration in a rice introgression line with enhanced alkali tolerance.
Liu et al., Changchun, China. In Plant Physiol Biochem, 2013
To investigate the possible genetic basis of alkali tolerance in rice, we generated an introgressed rice line (K83) with significantly enhanced tolerance to alkali stress compared to its recipient parental cultivar (Jijing88).
[K83 site affects PICK1 PDZ binding ability].
Zhu et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2012
After K83 site was substituted by other amino acid, the structure and binding energy were recalculated; meanwhile, site specific mutants were constructed using wild type full length cDNA as template.
Keratin gene mutations in disorders of human skin and its appendages.
Review
Mukhtar et al., Madison, United States. In Arch Biochem Biophys, 2011
Examples include epidermolysis bullosa simplex (EBS; K5, K14), keratinopathic ichthyosis (KPI; K1, K2, K10) i.e. epidermolytic ichthyosis (EI; K1, K10) and ichthyosis bullosa of Siemens (IBS; K2), pachyonychia congenita (PC; K6a, K6b, K16, K17), epidermolytic palmo-plantar keratoderma (EPPK; K9, (K1)), monilethrix (K81, K83, K86), ectodermal dysplasia (ED; K85) and steatocystoma multiplex.
SUMOylation of DLX3 by SUMO1 promotes its transcriptional activity.
Morasso et al., Bethesda, United States. In J Cell Biochem, 2011
We identified two potential SUMOylation sites in the N-terminal domain of DLX3 at positions K83 and K112.
Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates.
Grasby et al., Sheffield, United Kingdom. In Biochemistry, 2010
It is suggested that K83 acts as an electrostatic catalyst that stabilizes the transition state for phosphate diester hydrolysis.
Molecular evolution of regulatory genes in spruces from different species and continents: heterogeneous patterns of linkage disequilibrium and selection but correlated recent demographic changes.
Bousquet et al., Québec, Canada. In J Mol Evol, 2010
Selection and demographic signatures at the sequence level were investigated for five regulatory genes belonging to the knox-I family (KN1, KN2, KN3, KN4) and the HD-Zip III family (HB-3) in three Picea species affected by post-glacial recolonization in North America and Europe.
Characterization of horse spleen apoferritin reactive lysines by MALDI-TOF mass spectrometry combined with enzymatic digestion.
Wang et al., Columbia, United States. In Bioorg Chem, 2008
The result demonstrated that among all the lysine residues, K97, K83, K104, K67 and K143 are the reactive ones that can be addressed.
The assembly of the plasmodial PLP synthase complex follows a defined course.
Wrenger et al., Hamburg, Germany. In Plos One, 2007
Furthermore, changing D26, K83 and K151 (DKK), amino acids from the active site of Pdx1, to alanine obstructs not only enzyme activity but also formation of the complex.
A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.
GeneRIF
van Geel et al., Maastricht, Netherlands. In J Med Genet, 2005
A heterozygous missense mutation in hHb3 causing the substitution of a glutamic acid by a lysine at position 407 in the helix termination motif defines this particular residue as a trichocyte keratin mutational hotspot associated with monilethrix.
Keratins of the human hair follicle.
GeneRIF
Schweizer et al., Heidelberg, Germany. In Int Rev Cytol, 2004
The KRTHB3 expression uniformly occurred in the midcortex region.
Bacteriophages of Streptococcus pneumoniae: a molecular approach.
Review
López et al., Madrid, Spain. In Microb Drug Resist, 1996
Dp-1 and Cp-1 are lytic phages, whereas HB-3 and EJ-1 are temperate phages.
A family of clostridial and streptococcal ligand-binding proteins with conserved C-terminal repeat sequences.
Review
Wren, London, United Kingdom. In Mol Microbiol, 1991
Similar repeat units are also found in the C-terminal region of four glucosyltransferases from Streptococcus mutans and Streptococcus downei, and in four lytic enzymes from Streptococcus pneumoniae and its bacteriophages (HB-3, Cp-1 and Cp-9).
A comparative analysis of biparental mating and selfing in pearl millet (Pennisetum typhoïdes) S & H : I. Nature of variation and changes in association.
Murty et al., New Delhi, India. In Theor Appl Genet, 1973
Comparison of means and variances within and between the two groups of progenies (A and T-series) and with those of released hybrids (HB-1, HB-2, HB-3, HB-4) for seventeen characters (six related to development, six to productivity, three to vegetative growth and one each to earliness and disease incidence) showed significant variation among the lines of the two series for synchrony of tillering, earliness, disease incidence, chlorophyll depth, grain hairiness, tiller number, plant height, length of earhead, grain yield and grain weight.
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