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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ubiquitin specific peptidase 7

HAUSP, USP7, herpesvirus-associated ubiquitin-specific protease
Top mentioned proteins: Ubiquitin, p53, mdm2, CAN, V1a
Papers on HAUSP
Identification of KSHV vIRF1 as a novel interaction partner of human deubiquitinase USP7.
New
Saridakis et al., Canada. In J Biol Chem, Feb 2016
Ubiquitin Specific Protease 7 (USP7) deubiquitinates p53 and Hdm2 and regulates their stability.
Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells.
New
Lim et al., Ch'ŏngju, South Korea. In Biochem Biophys Res Commun, Feb 2016
UNASSIGNED: USP7 is a deubiquitinating enzyme that involves the ubiquitin proteasome system (UPS) to maintain regulation of protein synthesis and degradation.
USP7 Is a Suppressor of PCNA Ubiquitination and Oxidative-Stress-Induced Mutagenesis in Human Cells.
New
Masutani et al., Nagoya, Japan. In Cell Rep, Jan 2016
In this study, we used an in vitro assay system to identify USP7 as a deubiquitinating enzyme of mono-ubiquitinated PCNA.
[Research progress on ubiquitin-specific protease in antiviral immunity].
Review
New
Wei-Lin et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, Jun 2015
USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response.
Deubiquitinases and the new therapeutic opportunities offered to cancer.
Review
New
Saridakis et al., Toronto, Canada. In Endocr Relat Cancer, Feb 2015
In this review, we recapitulate structure-function studies of the most studied DUBs including USP7, USP22, CYLD, UCHL1, BAP1, A20, as well as ataxin 3 and connect them to regulatory mechanisms and their growing protein interaction networks.
Histone H2B monoubiquitination: roles to play in human malignancy.
Review
New
Marsh et al., Sydney, Australia. In Endocr Relat Cancer, Feb 2015
The H2Bub1 enzymatic cascade involves E3 RING finger ubiquitin ligases, with the main E3 generally accepted to be the RNF20-RNF40 complex, and deubiquitinases including ubiquitin-specific protease 7 (USP7), USP22 and USP44.
An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies.
Wodrich et al., Tsukuba, Japan. In J Virol, 2014
We show that DBP oligomerization is required to selectively recruit the PML-NB components Sp100 and USP7.
Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).
Zhang et al., Nanjing, China. In Plos One, 2014
Here, we showed that MLL5 protein stability is cooperatively regulated by O-GlcNAc transferase (OGT) and ubiquitin-specific protease 7 (USP7).
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.
Impact
Ma et al., Houston, United States. In Nat Cell Biol, 2014
Mechanistically, ATM phosphorylates and stabilizes ZEB1 in response to DNA damage, ZEB1 in turn directly interacts with USP7 and enhances its ability to deubiquitylate and stabilize CHK1, thereby promoting homologous recombination-dependent DNA repair and resistance to radiation.
Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218).
Review
Kessler, Oxford, United Kingdom. In Expert Opin Ther Pat, 2014
The invention described in this review (WO2013030218) relates to compounds based on the quinazolin-4-one scaffold, their process of preparation and applications to inhibit the ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme (DUB), which is considered a potentially important new drug target for treating cancer and immunological disorders.
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.
Impact
Coffer et al., Utrecht, Netherlands. In Immunity, 2013
Expression of the deubiquitinase (DUB) USP7 was found to be upregulated and active in Treg cells, being associated with Foxp3 in the nucleus.
UVSSA and USP7, a new couple in transcription-coupled DNA repair.
Review
Marteijn et al., Rotterdam, Netherlands. In Chromosoma, 2013
In addition, we will focus on two new players involved in TC-NER which were recently identified: UV-stimulated scaffold protein A (UVSSA) and ubiquitin-specific protease 7 (USP7).
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Impact
Anderson et al., Boston, United States. In Cancer Cell, 2012
Here, we show that P5091 is an inhibitor of deubiquitylating enzyme USP7, which induces apoptosis in MM cells resistant to conventional and bortezomib therapies.
Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.
GeneRIF
Takahashi et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
Taken together, this is the first report demonstrating that USP7 is an IRS-1/2 deubiquitinating enzyme forming a negative feedback loop in insulin/IGF signaling.
The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNA.
GeneRIF
Schulz et al., Hannover, Germany. In J Virol, 2012
Recruitment of USP7 to LANA plays a role in the regulation of viral latent replication.
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.
Impact
Marteijn et al., Rotterdam, Netherlands. In Nat Genet, 2012
The UVSSA protein interacts with elongating RNA polymerase II, localizes specifically to UV-induced lesions, resides in chromatin-associated TC-NER complexes and is implicated in stabilizing the TC-NER master organizing protein ERCC6 (also known as CSB) by delivering the deubiquitinating enzyme USP7 to TC-NER complexes.
Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.
Impact
Tanaka et al., Ōsaka, Japan. In Nat Genet, 2012
The UVSSA protein forms a complex with USP7 (ref.
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
GeneRIF
Dianov et al., Oxford, United Kingdom. In Mol Cell, 2012
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.
GeneRIF
Shi et al., Shanghai, China. In Proc Natl Acad Sci U S A, 2012
A cell cycle-specific signaling event that relieves UHRF1 from its interaction with USP7, is reported.
Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.
GeneRIF
Sixma et al., Amsterdam, Netherlands. In Mol Cell, 2011
analysis of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase
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