Deubiquitinases and the new therapeutic opportunities offered to cancer.
Toronto, Canada. In Endocr Relat Cancer, Feb 2015
In this review, we recapitulate structure-function studies of the most studied DUBs including USP7, USP22, CYLD, UCHL1, BAP1, A20, as well as ataxin 3 and connect them to regulatory mechanisms and their growing protein interaction networks.
Histone H2B monoubiquitination: roles to play in human malignancy.
Sydney, Australia. In Endocr Relat Cancer, Feb 2015
The H2Bub1 enzymatic cascade involves E3 RING finger ubiquitin ligases, with the main E3 generally accepted to be the RNF20-RNF40 complex, and deubiquitinases including ubiquitin-specific protease 7 (USP7), USP22 and USP44.