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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Germ cell associated 2

Haspin, Gsg2, haploid germ cell-specific nuclear protein kinase
Top mentioned proteins: Histone, Aurora, Sgo1, Plk1, Bub1
Papers on Haspin
H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis.
Ma et al., Beijing, China. In Cell Cycle, Jan 2016
UNASSIGNED: Haspin-catalyzed histone H3 threonine 3 (Thr3) phosphorylation facilitates chromosomal passenger complex (CPC) docking at centromeres, regulating indirectly chromosome behavior during somatic mitosis.
Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline.
Chen et al., Baltimore, United States. In Cell, Dec 2015
Finally, compromising the activity of the H3T3 kinase Haspin enhances the H3T3A but suppresses the H3T3D phenotypes.
Chromosome segregation regulation in human zygotes: altered mitotic histone phosphorylation dynamics underlying centromeric targeting of the chromosomal passenger complex.
Baart et al., Rotterdam, Netherlands. In Hum Reprod, Oct 2015
SUMMARY ANSWER: Investigation of the regulatory kinase pathways involved in centromeric CPC targeting revealed normal phosphorylation dynamics of histone H2A at T120 (H2ApT120) by Bub1 kinase and subsequent recruitment of Shugoshin, but phosphorylation of histone H3 at threonine 3 (H3pT3) by Haspin failed to show the expected centromeric enrichment on metaphase chromosomes in the zygote.
Bisubstrate inhibitor approach for targeting mitotic kinase Haspin.
Uri et al., Tartu, Estonia. In Bioconjug Chem, Mar 2015
During the past decade, the basophilic atypical kinase Haspin has emerged as a key player in mitosis responsible for phosphorylation of Thr3 residue of histone H3.
Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores.
Taylor et al., Toledo, United States. In Nat Commun, 2014
Finally, Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool, while Aurora B and Mps1 play minimal roles in maintaining CPC localization once cells are in mitosis.
Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint.
Santocanale et al., Galway, Ireland. In Biol Open, 2014
Consistent with published data we find that upon PLK1 inhibition, phosphoThr3-H3, a marker of Haspin activity, is reduced.
The structural mechanisms that underpin mitotic kinase activation.
Bayliss et al., Oxford, United Kingdom. In Biochem Soc Trans, 2013
These include members of the Cdk (cyclin-dependent kinase), Plk (Polo-like kinase), Aurora, Nek (NimA-related kinase) and Bub families, as well as Haspin, Greatwall and Mps1/TTK.
On the molecular mechanisms of mitotic kinase activation.
Yeoh et al., Leicester, United Kingdom. In Open Biol, 2012
These mitotic phosphorylation events are catalysed by several families of protein kinases, including Auroras, Cdks, Plks, Neks, Bubs, Haspin and Mps1/TTK.
DNA methylation-dependent modulator of Gsg2/Haspin gene expression.
Shiota et al., Tokyo, Japan. In J Reprod Dev, 2011
the tissue-dependent and differentially methylated region functions as a modulator in a DNA methylation-dependent manner; Gsg2 is under epigenetic control
A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.
Higgins et al., Boston, United States. In Curr Biol, 2011
Aurora B phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B and Haspin functions in mitosis
How protein kinases co-ordinate mitosis in animal cells.
Poon et al., Hong Kong, Hong Kong. In Biochem J, 2011
In the present review, we will focus on classic mitotic kinases, such as cyclin-dependent kinases, Polo-like kinases and Aurora kinases, as well as more recently characterized players such as NIMA (never in mitosis in Aspergillus nidulans)-related kinases, Greatwall and Haspin.
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.
Higgins et al., Boston, United States. In Science, 2010
phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B during mitosis
Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.
Funabiki et al., New York City, United States. In Science, 2010
This binding mediates recruitment of the CPC to chromosomes and the resulting activation of its kinase subunit Aurora B. Consistently, modulation of the kinase activity of Haspin, which phosphorylates H3T3, leads to defects in the Aurora B-dependent processes of spindle assembly and inhibition of nuclear reformation.
Two histone marks establish the inner centromere and chromosome bi-orientation.
Watanabe et al., Tokyo, Japan. In Science, 2010
findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells
Haspin: a newly discovered regulator of mitotic chromosome behavior.
Higgins, Boston, United States. In Chromosoma, 2010
Haspin is a relatively newly discovered kinase that phosphorylates histone H3 during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW]
Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation.
Stukenberg et al., Charlottesville, United States. In Science, 2008
TD-60 is critical to localize both the CPC and Haspin kinase activity to centromeres and thus regulates Aurora-B at several levels.
Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases.
Higgins, Boston, United States. In Cell Mol Life Sci, 2003
Haspin homologues are found in animals, plants and fungi, suggesting an origin early in eukaryotic evolution.
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