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Hyaluronan synthase 1

HAS1, HA synthase, H as, hyaluronate synthase, hyaluronan synthase 1
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAS3, ACID, CD44, CAN, hyaluronidase
Papers on HAS1
PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines.
New
Zákány et al., Debrecen, Hungary. In Int J Oncol, Jan 2016
Three isoforms of plasma membrane-bound hyaluronan synthases (HAS 1, 2 and 3) secrete and simultaneously bind pericellular HA.
Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.
New
Inoue et al., Odawara, Japan. In J Biol Chem, Jan 2016
Here we report that TGF-β1, basic FGF, EGF, and PDGF-BB commonly enhance total amount of HA in skin fibroblasts through up-regulation of HAS expression, but molecular size of newly produced HA is dependent on HYBID expression levels.
Esophageal squamous cell carcinoma cells modulate chemokine expression and hyaluronan synthesis in fibroblasts.
New
Fischer et al., Düsseldorf, Germany. In J Biol Chem, Jan 2016
KYSE-410 induced the mRNA expression of HA synthase 2 (Has2) in normal skin fibroblasts (SF) only in direct co-cultures.
Hyaluronan does not regulate human epidermal keratinocyte proliferation and differentiation.
New
Flamion et al., Namur, Belgium. In J Biol Chem, Jan 2016
UNASSIGNED: Hyaluronan (HA) is synthesized by three HA synthases (HAS1, 2, and 3) and secreted in the extracellular matrix.
A novel epigenetic mechanism regulating hyaluronan production in pancreatic cancer cells.
New
Hirata et al., Kitakyūshū, Japan. In Clin Exp Metastasis, Dec 2015
mRNA expression of HA synthase (HAS) genes was investigated by real-time RT-PCR.
Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia.
New
Fischer et al., Düsseldorf, Germany. In Arterioscler Thromb Vasc Biol, Dec 2015
HA is synthesized by 3 different HA synthases (HAS1, HAS2, and HAS3).
Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.
New
Plaas et al., Chicago, United States. In Osteoarthritis Cartilage, Nov 2015
Since intra-articular injection of hyaluronan (HA) can attenuate injury-induced osteoarthritis in wild-type (WT) mice, we investigated a role for HA in the response to cartilage injury in mice lacking HA synthase 1 (Has1(-/-)).
Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism.
Review
New
Natowicz et al., Winnipeg, Canada. In World J Biol Chem, Sep 2015
Its levels are determined, in part, by the hyaluronan synthases, HAS1, HAS2, and HAS3, and three hyaluronidases, HYAL1, HYAL2 and HYAL3.
[The expression and clinical significance of hyaluronan synthase in nasal polyps].
New
Liu et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, Jun 2015
OBJECTIVE: To study the expression of hyaluronan synthasel-3 (HAS1-3) in nasal polyps, and discuss their clinical significance.
Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer.
Ren et al., Chongqing, China. In Int J Clin Exp Pathol, 2014
HA synthase 2 (HAS2) catalyzes the sysnthesis of HA, but its role in breast tumorigenesis remains unclear.
Hyaluronan Synthase: The Mechanism of Initiation at the Reducing End and a Pendulum Model for Polysaccharide Translocation to the Cell Exterior.
Review
Weigel, Oklahoma City, United States. In Int J Cell Biol, 2014
Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete.
Regulated Hyaluronan Synthesis by Vascular Cells.
Review
Vigetti et al., Varese, Italy. In Int J Cell Biol, 2014
HA synthesis is regulated by several factors, including the phosphorylation of HA synthase 2 (HAS2) and other covalent modifications including ubiquitination and O-GlcNAcylation.
Hyaluronan synthase 1: a mysterious enzyme with unexpected functions.
Review
Rilla et al., Kuopio, Finland. In Front Immunol, 2014
Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis.
Regulation of Synthesis and Roles of Hyaluronan in Peritoneal Dialysis.
Review
Sitter et al., München, Germany. In Biomed Res Int, 2014
HA is synthesized in humans by HA synthase (HAS) enzymes 1, 2, and 3, which are encoded by the corresponding HAS genes.
Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth.
GeneRIF
Mahendroo et al., Dallas, United States. In Endocrinology, 2012
analysis of changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth: Has1 is expressed in preterm birth, while Has2 is induced at term
Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.
GeneRIF
Maytin et al., Cleveland, United States. In J Invest Dermatol, 2012
Selective loss of Has1 and Has3 leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.
Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility.
GeneRIF
Acott et al., Portland, United States. In Invest Ophthalmol Vis Sci, 2011
HA chains synthesized by HAS1 and HAS2 contribute to outflow resistance, while hyaluronan produced by HAS3 does not appear to play a significant role.
Estradiol inhibits hyaluronic acid synthase 1 expression in human vascular smooth muscle cells.
GeneRIF
Fischer et al., Düsseldorf, Germany. In Basic Res Cardiol, 2011
this study provides strong evidence that HAS1-driven Hyaluonan-synthesis is a target of estradiol in human vascular smooth muscle cells
Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis.
GeneRIF
Lokeshwar et al., Hannover, Germany. In Cancer, 2011
HYAL-1 and HAS1 expression predicted bladder cancer metastasis, and HYAL-1 expression also predicted disease-specific survival.
Exploration of essential gene functions via titratable promoter alleles.
Impact
Hughes et al., Toronto, Canada. In Cell, 2004
We identified genes involved in ribosome biogenesis (HAS1, URB1, and URB2), protein secretion (SEC39), mitochondrial import (MIM1), and tRNA charging (GSN1).
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