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Stabilin 2

Hare, stabilin-2
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, CAN, stabilin-1, PCL
Papers on Hare
Child maltreatment, callous-unemotional traits, and defensive responding in high-risk children: An investigation of emotion-modulated startle response.
Cicchetti et al., Rochester, United States. In Dev Psychopathol, Nov 2015
Developmental models of CU traits have focused on biological and genetic risk factors that contribute to hypoarousal and antisocial behavior, but have focused less on environmental influences (Blair, 2004; Daversa, 2010; Hare, Frazell, & Cox, 1978; Krueger, 2000; Shirtcliff et al., 2009; Viding, Fontaine, & McCrory, 2012).
[Can psychopathy be detected psychophysiologically?].
Stöhr et al., Vienna, Austria. In Wien Med Wochenschr, Aug 2015
Psychopathic behavior and personality traits were identified by means of the Hare Psychopathy Checklist-Revised (PCL-R) and offenders were divided into 4 groups with PCL-R scores of 0-10, 11-20, 21-30 and 31-40, respectively.
A latent variable analysis of the Psychopathy Checklist-Revised and behavioral inhibition system/behavioral activation system factors in North American and Swedish offenders.
Johansson et al., Örebro, Sweden. In Personal Disord, Jul 2015
However, no studies have examined how latent BIS/BAS factors and the 4 empirically derived Psychopathy Checklist-Revised (PCL-R) psychopathy factors (Hare & Neumann, 2008) are associated across different cultures.
Cu,Zn superoxide dismutases from Tetrahymena thermophila: molecular evolution and gene expression of the first line of antioxidant defenses.
Santovito et al., Padova, Italy. In Protist, Feb 2015
Our in silico analyses of the tt-sod1a and tt-sod1b promoter regions revealed putative consensus sequences similar to half Antioxidant Responsive Elements (hARE), suggesting that the transcription of these genes directly depends on ROS formation.
Tissue-specific splice variants of HARE/Stabilin-2 are expressed in bone marrow, lymph node, and spleen.
Harris et al., Lincoln, United States. In Biochem Biophys Res Commun, Feb 2015
The hyaluronan receptor for endocytosis (HARE), or Stabilin-2, is the mammalian endocytic clearance receptor for HA, heparin, advanced glycation end-products, acetylated and oxidized low-density lipoproteins and collagen N-terminal propeptides.
Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF.
Mikulits et al., Vienna, Austria. In Plos One, 2014
Notably, p19ARF-/- LSECs express the endothelial markers CD31, vascular endothelial growth factor receptor (VEGFR)-2, VE-cadherin, von Willebrand factor, stabilin-2 and CD146 suggesting that these cells harbor and maintain an endothelial phenotype.
Targeting the IGF-1R: The Tale of the Tortoise and the Hare.
Girnita et al., Stockholm, Sweden. In Front Endocrinol (lausanne), 2014
The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development and maintenance of cancer.
Hyaluronic acid nanoparticles for active targeting atherosclerosis.
Kim et al., Taegu, South Korea. In Biomaterials, 2014
Since the representative hallmark of atherosclerosis in its pathogenic process is the over-expression of the receptors for hyaluronic acid (HA) such as stabilin-2 and CD44, we herein investigated the potential of HA nanoparticles (HA-NPs) as the carrier for active targeting atherosclerosis.
HARE-Mediated Endocytosis of Hyaluronan and Heparin Is Targeted by Different Subsets of Three Endocytic Motifs.
Weigel et al., Penn Hills, United States. In Int J Cell Biol, 2014
The hyaluronan (HA) receptor for endocytosis (HARE) is a multifunctional recycling clearance receptor for 14 different ligands, including HA and heparin (Hep), which bind to discrete nonoverlapping sites.
The European Hare (Lepus europaeus): A Picky Herbivore Searching for Plant Parts Rich in Fat.
Hackländer et al., Vienna, Austria. In Plos One, 2014
European hares of both sexes rely on fat reserves, particularly during the reproduc-tive season.
Haplodiploidy and the evolution of eusociality: worker revolution.
West et al., Oxford, United Kingdom. In Am Nat, 2014
Trivers and Hare observed that for this to occur, workers have to direct helping preferentially toward the production of sisters.
Cross talk between engulfment receptors stabilin-2 and integrin αvβ5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes.
Kim et al., Taegu, South Korea. In Mol Cell Biol, 2012
knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis.
Miyajima et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2012
A dramatic elevation in circulating hyaluronic acid levels in Stab2-deficient mice without any overt phenotype, is reported.
Increased expression of CD44 in hypertrophied ligamentum flavum and relevance of splice variants CD44v5 and CD44v6.
Paletta et al., Marburg an der Lahn, Germany. In Acta Neurochir (wien), 2012
Ligament Flavum (LF) hypertrophy is accompanied by increased CD44 and CD44v5 expression. CD44v6 expression is not enhanced in LF hypertrophy.
What lies behind the wish to hasten death? A systematic review and meta-ethnography from the perspective of patients.
Balaguer et al., Barcelona, Spain. In Plos One, 2011
The seven-stage Noblit and Hare approach was applied, using reciprocal translation and line-of-argument synthesis.
Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling.
Shindo et al., Matsumoto, Japan. In Peptides, 2011
Adrenomedullin treatment from day 14 to day 20 promoted the differentiation of stabilin-2-positive endothelial cells.
Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver.
Kim et al., Taegu, South Korea. In Blood, 2011
we show that stabilin-1 and stabilin-2 in hepatic sinusoidal endothelial cells (HSECs) are critical in effectively clearing damaged RBCs in mouse liver
One thousand and one ways of making functionally similar transcriptional enhancers.
Veitia, Paris, France. In Bioessays, 2008
Recently, Hare et al., using elegant wet and computational approaches uncovered a series of enhancers driving the expression of the even-skipped gene in scavenger flies (Sepsidae).
The hydrogen exchange core and protein folding.
Woodward et al., Saint Paul, United States. In Protein Sci, 1999
Other studies of partially folded bovine pancreatic trypsin inhibitor (Barbar E, Barany G, Woodward C, 1995, Biochemistry 34:11423-11434; Barber E, Hare M, Daragan V, Barany G, Woodward C, 1998, Biochemistry 37:7822-7833), suggest that developing cores have site-specific energy barriers between microstates, one disordered, and the other(s) more ordered.
NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues.
Jaiswal et al., Philadelphia, United States. In Cancer Metastasis Rev, 1993
The high level of expression of the NQO1 gene and its induction by beta-NF and BHA require the presence of an AP1 binding site contained within the human Antioxidant Response Element (hARE) and are mediated by products of proto-oncogenes, Jun and Fos.
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