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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cell division cycle 37 homolog

HARC, Hsp90-associating relative of Cdc37
CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008] (from NCBI)
Papers on HARC
Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock.
GeneRIF
Scholz et al., Australia. In Biochemistry, 2008
C-terminal domain of Harc is a key determinant of its cochaperone functions
Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37.
GeneRIF
Scholz et al., Melbourne, Australia. In Biochemistry, 2005
Harc forms dimers in vitro. The structural similarities between Harc and Cdc37 suggest that Harc may function to regulate the Hsp90-mediated folding of Cdc37-dependent protein kinases into functional conformations via dimerization with Cdc37.
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