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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Haptoglobin

Haptoglobin, haptoglobin,, HP1, HP2
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, ACID, HAD, V1a
Papers using Haptoglobin antibodies
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures
Supplier
Cybulsky Myron I. et al., In The Journal of Cell Biology, 2002
... Primary antibodies included mouse anti–human CD49d clone HP2/1 (AbD Serotec) and clone 44H6 (gift ...
Papers on Haptoglobin
Serum Haptoglobin as a novel molecular biomarker predicting colorectal cancer hepatic metastasis.
New
Ran et al., Beijing, China. In Int J Cancer, Feb 2016
Our previous studies showed Haptoglobin was highly expressed in primary CRC tissues, especially in heterochronous metastatic cases.
De Novo Truncating Mutations in the kinetochore-microtubules attachment gene CHAMP1 Cause Syndromic Intellectual Disability.
New
Bézieau et al., Nantes, France. In Hum Mutat, Feb 2016
Besides, our functional studies show that CHAMP1 protein variants are delocalized from chromatin and are unable to bind to two of its direct partners, POGZ and HP1.
The evolutionary landscape of PRC1 core components in green lineage.
Review
New
Shen et al., Changsha, China. In Planta, Feb 2016
Plant LHP1 as the homolog of non-PRC1 protein HP1 was recruited to fulfill the role of Pc counterpart.
Microparticle derived proteins as potential biomarkers for cerebral vasospasm post subarachnoid hemorrhage. A preliminary study.
New
Ashley et al., Maywood, United States. In Clin Neurol Neurosurg, Jan 2016
Haptoglobin, fibrinogen α and γ chain, synaptic nuclear envelope protein 2, and hemoglobin subunits α and β were upregulated.
Feasibility of Affibody Molecule-Based PNA-Mediated Radionuclide Pretargeting of Malignant Tumors.
New
Karlström et al., Uppsala, Sweden. In Theranostics, Dec 2015
To test this hypothesis, we designed an Affibody-PNA chimera ZHER2:342-SR-HP1 containing a 15-mer HP1 PNA recognition tag and a complementary HP2 hybridization probe permitting labeling with both (125)I and (111)In.
A role for Separase in telomere protection.
New
Cenci et al., Roma, Italy. In Nat Commun, Dec 2015
We demonstrate that Separase binds terminin proteins and HP1, and that it is enriched at telomeres.
Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks.
Review
New
Price et al., Boston, United States. In J Mol Biol, Dec 2015
DSBs promote rapid accumulation of repressive complexes, including HP1, the NuRD complex, H2A.Z and histone methyltransferases at the DSB.
The alternative role of DNA methylation in splicing regulation.
Review
New
Ast et al., Tel Aviv-Yafo, Israel. In Trends Genet, May 2015
The first involves modulation of the elongation rate of RNA polymerase II (Pol II) by CCCTC-binding factor (CTCF) and methyl-CpG binding protein 2 (MeCP2); the second involves the formation of a protein bridge by heterochromatin protein 1 (HP1) that recruits splicing factors onto transcribed alternative exons.
The telomere bouquet regulates meiotic centromere assembly.
New
Impact
Cooper et al., Bethesda, United States. In Nat Cell Biol, Apr 2015
Kinetochore proteins and the centromeric histone H3 variant Cnp1 fail to localize to those centromeres that exhibit spindle attachment defects in the bouquet's absence.
Niacin in the Treatment of Hyperlipidemias in Light of New Clinical Trials: Has Niacin Lost its Place?
Review
Žák et al., Praha, Czech Republic. In Med Sci Monit, 2014
In this paper, we analyze the mechanisms underlying the hypolipidemic and antiatherogenic effects of niacin as well as some limitations of the designs of the AIM HIGH and HP2-THRIVE studies.
The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing.
Impact
Theurkauf et al., Worcester, United States. In Cell, 2014
The Drosophila HP1 homolog Rhino is required for germline piRNA production.
Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development.
Review
Buehler et al., Zürich, Switzerland. In Front Physiol, 2013
Haptoglobin (Hp) is the primary Hb-binding protein in human plasma, which attenuates the adverse biochemical and physiologic effects of extracellular Hb.
Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation.
Impact
Bulavin et al., Singapore, Singapore. In Cancer Cell, 2013
Wip1 was required for epigenetic remodeling of repetitive DNA elements through regulation of BRCA1 interaction with HP1, the recruitment of DNA methyltransferases, and subsequent DNA methylation.
Endogenous nuclear RNAi mediates behavioral adaptation to odor.
Impact
L'Etoile et al., San Francisco, United States. In Cell, 2013
Concomitant with increased odr-1 siRNA in AWC, we observe increased binding of the HP1 homolog HPL-2 at the odr-1 locus in AWC and reduced odr-1 mRNA in adapted animals.
A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.
Impact
Narlikar et al., San Francisco, United States. In Nature, 2013
Central to heterochromatin spread is heterochromatin protein 1 (HP1), which recognizes H3K9-methylated chromatin, oligomerizes and forms a versatile platform that participates in diverse nuclear functions, ranging from gene silencing to chromosome segregation.
Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α.
GeneRIF
Decottignies et al., Brussels, Belgium. In Nat Struct Mol Biol, 2012
Downregulation of the telomeric noncoding RNA requires SUV39H1 and HP1A.
Zonulin, regulation of tight junctions, and autoimmune diseases.
GeneRIF
Fasano, Baltimore, United States. In Ann N Y Acad Sci, 2012
discovery of zonulin, the only known physiologic modulator of intercellular TJs described so far, has increased our understanding of the intricate mechanisms that regulate the intestinal epithelial paracellular pathway
Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism.
Impact
GeneRIF
Yamamoto et al., Sendai, Japan. In Cell, 2012
Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a), which demasculinizes them.
Appearance and heterochromatin localization of HP1α in early mouse embryos depends on cytoplasmic clock and H3S10 phosphorylation.
GeneRIF
Borsuk et al., Warsaw, Poland. In Cell Cycle, 2012
Elimination of HP1alpha by siRNA interfered with centromere relocation from heterochromatin surrounding NPBs to pro-chromocenters at the two-cell stage but did not affect preimplantation develoment to the blastocyst stage.
Alpha-defensin overexpression in patients with Bell's palsy and Ramsay Hunt syndrome.
GeneRIF
Sawa et al., Japan. In Ann Otol Rhinol Laryngol, 2012
alpha-Defensin (DEFA3)was the third most differentially overexpressed gene and may be related to the onset of Bell's palsy and Ramsay Hunt Syndrome.
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