The alternative role of DNA methylation in splicing regulation.
Tel Aviv-Yafo, Israel. In Trends Genet, May 2015
The first involves modulation of the elongation rate of RNA polymerase II (Pol II) by CCCTC-binding factor (CTCF) and methyl-CpG binding protein 2 (MeCP2); the second involves the formation of a protein bridge by heterochromatin protein 1 (HP1) that recruits splicing factors onto transcribed alternative exons.
Zonulin, regulation of tight junctions, and autoimmune diseases.
Baltimore, United States. In Ann N Y Acad Sci, 2012
discovery of zonulin, the only known physiologic modulator of intercellular TJs described so far, has increased our understanding of the intricate mechanisms that regulate the intestinal epithelial paracellular pathway