Molecular mechanisms of congenital hyperinsulinism.
London, United Kingdom. In J Mol Endocrinol, Apr 2015
Mutations in GLUD1 and HADH lead to leucine-induced HH, and these two genes encode the key enzymes glutamate dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase which play a key role in amino acid and fatty acid regulation of insulin secretion respectively.
Current gene therapy using viral vectors for chronic pain.
Pittsburgh, United States. In Mol Pain, 2014
Dr. Hao group addresses the observation that the pro-inflammatory cytokines are an important shared mechanism underlying both neuropathic pain and the development of opioid analgesic tolerance and withdrawal.
Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia.
Singapore, Singapore. In World J Diabetes, 2014
The observation of protein induced hypoglycaemia in patients with mutations in GLUD1 gene, encoding the enzyme glutamate dehydrogenase (GDH) and HADH gene, encoding for the enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase has provided new mechanistic insights into the regulation of insulin secretion by amino acid and fatty acid metabolism.
Connecting with an old partner in a new way.
Cambridge, United Kingdom. In Cancer Cell, 2013
In this issue of Cancer Cell, Hao and colleagues report a non-canonical interaction between the insulin receptor substrate 1 and certain oncogenic variants of the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K).
Regulation of cellular metabolism by protein lysine acetylation.
Shanghai, China. In Science, 2010
Acetylation activated enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase in fatty acid oxidation and malate dehydrogenase in the TCA cycle, inhibited argininosuccinate lyase in the urea cycle, and destabilized phosphoenolpyruvate carboxykinase in gluconeogenesis.
The neuropathogenesis of AIDS.
Philadelphia, United States. In Nat Rev Immunol, 2005
HIV-associated dementia (HAD) is an important complication of the central nervous system in patients who are infected with HIV-1.