Common genetic variants in NEFL influence gene expression and neuroblastoma risk.
Napoli, Italy. In Cancer Res, 2015
In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability.
E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics.
Lexington, United States. In Cell Adh Migr, 2013
HACE1, XIAP, and Skp1-Cul1-F-box bind to Rac1 and cause its ubiquitination and degradation, thus suppressing lamellipodium protrusions, while PIAS3, a SUMO ligase, activates Rac1 to promote lamellipodium dynamics.