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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1

HACE1
Top mentioned proteins: Ubiquitin, Rac1, Rab5, Akt, Blimp-1
Papers on HACE1
HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome.
New
Bonthron et al., Lübeck, Germany. In J Med Genet, Dec 2015
RESULTS: In both families, biallelic loss-of-function mutations in HACE1 were identified.
HACE1 mediated K27 ubiquitin linkage leads to YB-1 protein secretion.
New
Maddika et al., Hyderābād, India. In Cell Signal, Dec 2015
We also identified HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains.
Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression.
New
Lippman et al., Miami, United States. In Oncogene, Nov 2015
To identify genes capable of cooperating with HER2/neu to fully transform mammary epithelial cells, we used an insertional mutagenesis screen on cells isolated from wild-type neu expressing mice and identified the E3 ligase HACE1 as HER2 cooperative tumor suppressor gene.
Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan.
New
Nakamura et al., Isehara, Japan. In Mod Pathol, Oct 2015
The cases were characterized by immunohistochemistry, high-resolution oligonucleotide microarray, and fluorescence in situ hybridization (FISH) at five different loci: 1q21.3 (CKS1B), 6q16.3 (HACE1), 7p22.3 (MAFK), 9q33.3 (PPP6C), and 9q34.3 (ASS1, CARD9) using formalin-fixed paraffin-embedded sections.
Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction.
New
Sorensen et al., Vancouver, Canada. In Oncogene, Aug 2015
The Hace1 E3 ligase is a tumor suppressor inactivated in diverse human cancers.
Common genetic variants in NEFL influence gene expression and neuroblastoma risk.
Maris et al., Napoli, Italy. In Cancer Res, 2015
In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability.
HACE1, a potential tumor suppressor gene on 6q21, is not involved in extranodal natural killer/T-cell lymphoma pathophysiology.
Schmitt et al., Paris, France. In Am J Pathol, 2014
Of interest, this deleted region contains four candidate tumor suppressor genes whose decreased expression has been confirmed at the mRNA level: PRDM1, ATG5, AIM1, and HACE1.
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.
Impact
Hu et al., Shanghai, China. In Cancer Cell, 2014
Here we report that tumor-suppressor HACE1, a ubiquitin ligase, ubiquitylates OPTN and promotes its interaction with p62/SQSTM1 to form the autophagy receptor complex, thus accelerating autophagic flux.
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.
Liu et al., Ottawa, Canada. In Nat Commun, 2013
The HECT E3 ubiquitin ligase HACE1 is a tumour suppressor known to regulate Rac1 activity under stress conditions.
E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics.
Huang et al., Lexington, United States. In Cell Adh Migr, 2013
HACE1, XIAP, and Skp1-Cul1-F-box bind to Rac1 and cause its ubiquitination and degradation, thus suppressing lamellipodium protrusions, while PIAS3, a SUMO ligase, activates Rac1 to promote lamellipodium dynamics.
New insights in the regulation of Rab GTPases by G protein-coupled receptors.
Parent et al., Sherbrooke, Canada. In Small Gtpases, 2013
Recently published in the Journal of Cell Science, Lachance et al. present a novel role for ubiquitylation of Rab11a by a β2AR/HACE1 complex in regulating Rab11a activity and β2AR trafficking.
Molecular underpinning of extranodal NK/T-cell lymphoma.
Review
Gaulard et al., Taiwan. In Best Pract Res Clin Haematol, 2013
Frequent deletions and promoter methylations in PRDM1, ATG5, AIM1, FOXO3, HACE1 mapping to 6q21-q25, suggest their roles as potential tumor suppressors.
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
Impact
Maris et al., Philadelphia, United States. In Nat Genet, 2012
We identified two new associations at 6q16, the first within HACE1 (rs4336470; combined P=2.7×10(-11); odds ratio 1.26, 95% confidence interval (CI) 1.18-1.35)
Ubiquitylation of active Rac1 by the E3 ubiquitin-ligase HACE1.
Review
Lemichez et al., Nice, France. In Small Gtpases, 2012
We now report in the November issue of Developmental Cell that the E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of GTP-bound Rac1.
The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1.
GeneRIF
Lemichez et al., Nice, France. In Dev Cell, 2011
The HACE1 expression increases the ubiquitylation of Rac1, when the GTPase is activated by point mutations or by the GEF-domain of Dbl.
Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations.
GeneRIF
Saavalainen et al., Helsinki, Finland. In Eur J Hum Genet, 2011
The 6q21-22 region was confirmed as a celiac disease susceptibility locus and harbors multiple independent associations, some of which may implicate ubiquitin-pathways in celiac disease susceptibility, such as mutations in gene HACE1.
Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type.
GeneRIF
Gaulard et al., Créteil, France. In Blood, 2010
Deregulation of the tumor suppressor HACE1 is associated with natural killer/T-cell lymphoma, nasal type.
Methylation of HACE1 in gastric carcinoma.
GeneRIF
Hibi et al., Yokohama, Japan. In Anticancer Res, 2009
Aberrant methylation of the HACE1 gene is associated with gastric carcinoma.
Aberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer.
GeneRIF
Sanada et al., Yokohama, Japan. In Anticancer Res, 2008
Aberrant methylation of the HACE1 gene was detected in 9 out of the 32 (28%) primary colon carcinomas.
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.
Impact
GeneRIF
Penninger et al., Vienna, Austria. In Nat Med, 2007
HACE1 is a candidate chromosome 6q21 tumor-suppressor gene involved in multiple cancers.
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