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Hyaluronan binding protein 2

HABP, FSAP, factor VII-activating protease, PHBP
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, Plasminogen, CD45
Papers on HABP
Genome-Wide Association Analysis of Young Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.
Mitchell et al., Göteborg, Sweden. In Stroke, Feb 2016
In a further analysis in an independent sample, we found that 2 single nucleotide polymorphisms in high linkage disequilibrium with rs11196288 were significantly associated with total plasma factor VII-activating protease levels, a product of HABP2.
DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC.
Zeerleder et al., Hamilton, Canada. In Blood Rev, Jan 2016
This release is a highly regulated process mediated among others by serine proteases, such as factor VII-activating protease (FSAP) and DNase1.
FSAP-mediated nucleosome release from late apoptotic cells is inhibited by autoantibodies present in SLE.
Zeerleder et al., Amsterdam, Netherlands. In Eur J Immunol, Jan 2016
Factor VII-activating protease (FSAP) is activated in serum upon contact with dead cells, and releases nucleosomes from late apoptotic cells into the extracellular environment.
Hyaluronan in Human Vocal Folds in Smokers and Nonsmokers-A Histochemical Study.
Laurent et al., Oslo, Norway. In J Voice, Nov 2015
A direct method for hyaluronan histochemistry using a hyaluronan-binding protein probe (HABP) was used to visualize the polysaccharide.
Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.
Zeerleder et al., Bangkok, Thailand. In Plos Negl Trop Dis, Aug 2015
This study analyzed the plasma levels of nucleosomes, FSAP-activation (nucleosome-releasing factor), and neutrophil activation, as evidenced by neutrophil-elastase (ELA) complexes, in sympatric Lao patients with scrub typhus and murine typhus.
Evaluation of Histidylated Arginine-Grafted Bioreducible Polymer To Enhance Transfection Efficiency for Use as a Gene Carrier.
Kim et al., Salt Lake City, United States. In Mol Pharm, Aug 2015
Here, we designed a histidylated arginine-grafted bioreducible polymer (HABP) as a nonviral gene carrier using different ratios of histidine and arginine-grafted bioreducible poly(cystaminebis(acrylamide)-diaminohexane) (poly(CBA-DAH)), known as ABP, to increase cellular uptake and endosomal escape efficiency.
Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP).
Kanse et al., Oslo, Norway. In Thromb Haemost, Apr 2015
Factor VII (FVII) activating protease (FSAP) is a circulating protease with a putative function in blood coagulation and fibrinolysis.
Mce4F Mycobacterium tuberculosis protein peptides can inhibit invasion of human cell lines.
Patarroyo et al., Bogotá, Colombia. In Pathog Dis, Apr 2015
Rv3494c peptides 38370 ((21)LSVMAIFYLRLPATFGIGTY(40)), 38373 ((81)HMRLNSGTAIPSNVTATVRSY(100)) and 38379 ((201)IDQAGPFLQAQIRAGGDIKSY(220)) showed to be HABP and inhibited mycobacterial entry to A549 cells and peptide 38382 ((261)RPSFPALAASLANLGRVGVIY(280)) bind to U937 and inhibited the mycobacterial entry to this cell line; all of these sequences play an important role in cell line recognition and invasion, and may thus be considered in the search for prophylactic candidates against tuberculosis.
Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice.
Kanse et al., Gießen, Germany. In Eur J Neurosci, Apr 2015
Factor VII activating protease (FSAP) is a circulating protease with a putative role in hemostasis, remodeling and inflammation.
Tedizolid: a novel oxazolidinone with potent activity against multidrug-resistant gram-positive pathogens.
Karlowsky et al., Winnipeg, Canada. In Drugs, Feb 2015
Tedizolid is currently undergoing additional Phase III clinical trials for the treatment of hospital-acquired bacterial pneumonia (HABP) and ventilated nosocomial pneumonia (VNP).
Hydrogel patterning by diffusion through the matrix and subsequent light-triggered chemical immobilization.
Ossipov et al., Uppsala, Sweden. In Acs Appl Mater Interfaces, Feb 2015
Moreover, calcium binding to the gradient HABP hydrogel reflects the pattern of immobilized BP groups eventually leading to the graded biomineralization of the matrix.
Diabetes-independent increase of factor VII-activating protease activation in patients with Gram-negative sepsis (melioidosis).
Zeerleder et al., Amsterdam, Netherlands. In J Thromb Haemost, 2015
BACKGROUND: The plasma protease factor VII-activating protease (FSAP) can release nucleosomes from late apoptotic cells.
Factor VII activating protease (FSAP): a novel protective factor in liver fibrosis.
Weiskirchen et al., Oslo, Norway. In Proteomics Clin Appl, 2014
Factor VII activating protease (FSAP) is a multifunctional serine protease that is mainly synthesized and secreted by hepatocytes.
Factor seven activating protease (FSAP): does it activate factor VII?
Mertens et al., Amsterdam, Netherlands. In J Thromb Haemost, 2012
FSAP activates single-chain urokinase-type plasminogen activator, but FVII appears remarkably resistant to activation.
Plasma factor VII-activating protease antigen levels and activity are increased in ischemic stroke.
Jern et al., Göteborg, Sweden. In J Thromb Haemost, 2012
Increased plasma FSAP antigen levels and activity were associated with ischemic stroke and all main etiologic subtypes.
Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a.
Huber-Lang et al., Gießen, Germany. In J Immunol, 2012
A high correlation between FSAP activity and C5a was found in multiple trauma patients
Factor seven activating protease activity levels in women with recurrent pregnancy loss.
Basili et al., Roma, Italy. In Reprod Sci, 2012
Data suggest that plasma FSAP activity levels were higher in women with recurrent pregnancy loss than in fertile women.
Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor.
Etscheid et al., Gießen, Germany. In Arterioscler Thromb Vasc Biol, 2012
Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor.
FSAP, a new player in inflammation?
Zeerleder et al., Amsterdam, Netherlands. In Hamostaseologie, 2011
Factor VII-activating protease (FSAP) is a serine protease in plasma that has a role in coagulation and fibrinolysis.
Factor VII activating protease. Single nucleotide polymorphisms light the way.
Etscheid et al., Gießen, Germany. In Hamostaseologie, 2011
SNP analyses indicate an important role for FSAP in the regulation of the haemostasis system as well as fibroproliferative inflammatory processes. [review]
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