Amino acid-linked porphyrin-nitroimidazole antibiotics targeting Porphyromonas gingivalis.
Westmead, Australia. In Org Biomol Chem, 03 Jan 2015
Previously, in order to inhibit P. gingivalis growth, we synthesised very effective 'Trojan horse' ester and amide-linked deuterporphyrin-nitroimidazole (DPIX-Nim) adducts that exploited this requirement to transport metronidazole-derived antibiotics with excellent antimicrobial selectivity and recognition by the HA2 porphyrin binding site.
New vaccines against influenza virus.
Atlanta, United States. In Clin Exp Vaccine Res, Jan 2014
The strategies of universal vaccines include the matrix 2 protein, the hemagglutinin HA2 stalk domain, and T cell-based multivalent antigens.
[Advances in research and development of universal influenza vaccines].
In Bing Du Xue Bao, Jan 2014
This review describes the research progress in conserved epitopes of influenza virus, the advances in the research and development of universal influenza vaccines based on the relatively conserved sequences of NP, M2e, HA2, and headless HA, the mechanisms of cross-protection, and the methods to improve cross-protection.
Atomic structure of the ectodomain from HIV-1 gp41.
Boston, United States. In Nature, 1997
These features, and the existence of a similar reversal of chain direction in the fusion pH-induced conformation of influenza virus HA2 and in the transmembrane subunit of Moloney murine leukaemia virus (Fig. 1a-d), suggest a common mechanism for initiating fusion.