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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 05 Dec 2014.

Myosin IG

HA2, K32
MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010] (from NCBI)
Top mentioned proteins: AE1, ACID, CAN, HAD, Tec
Papers on HA2
Amino acid-linked porphyrin-nitroimidazole antibiotics targeting Porphyromonas gingivalis.
New
Crossley et al., Westmead, Australia. In Org Biomol Chem, 03 Jan 2015
Previously, in order to inhibit P. gingivalis growth, we synthesised very effective 'Trojan horse' ester and amide-linked deuterporphyrin-nitroimidazole (DPIX-Nim) adducts that exploited this requirement to transport metronidazole-derived antibiotics with excellent antimicrobial selectivity and recognition by the HA2 porphyrin binding site.
Influenza M2 protein ion channel activity helps maintain the pandemic 2009 H1N1 hemagglutinin fusion competence during transport to the cell surface.
New
Wang et al., Silver Spring, United States. In J Virol, 03 Jan 2015
Cleavage of the HA precursor (HA0) into a surface receptor-binding subunit (HA1) and a fusion-inducing transmembrane subunit (HA2) by host cell enzymes primes HA for fusion competence by repositioning the fusion peptide to the newly created the N-terminus of HA2.
Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development.
New
Mignot et al., Palo Alto, United States. In Brain Behav Immun, 15 Dec 2014
We found that Pandemrix (2009 batch) and Arepanrix (2010 batch) showed 5 main viral proteins: hemagglutinin HA1 and HA2 subunits, neuraminidase NA, nucleoprotein NP, and matrix protein MA1 and non-viral proteins from the Gallus gallus growth matrix used in the manufacturing of the vaccines.
Live attenuated influenza A virus vaccine protects against A(H1N1)pdm09 heterologous challenge without vaccine associated enhanced respiratory disease.
New
Vincent et al., Ames, United States. In Virology, 28 Nov 2014
High levels of post-vaccination IgG serum antibodies targeting the H1N1pdm09 HA2 stalk domain were exclusively detected in the WIV group and associated with increased H1N1pdm09 virus infectivity in MDCK cells.
New vaccines against influenza virus.
Review
New
Kang et al., Atlanta, United States. In Clin Exp Vaccine Res, Jan 2014
The strategies of universal vaccines include the matrix 2 protein, the hemagglutinin HA2 stalk domain, and T cell-based multivalent antigens.
[Advances in research and development of universal influenza vaccines].
Review
New
He et al., In Bing Du Xue Bao, Jan 2014
This review describes the research progress in conserved epitopes of influenza virus, the advances in the research and development of universal influenza vaccines based on the relatively conserved sequences of NP, M2e, HA2, and headless HA, the mechanisms of cross-protection, and the methods to improve cross-protection.
The hemagglutinin of the influenza A(H1N1)pdm09 is mutating towards stability.
New
Ribas-Aparicio et al., Mexico. In Adv Appl Bioinform Chem, Dec 2013
We found nine changes that became prevalent: HA1 subunits D104N, K166Q, S188T, S206T, A259T, and K285E; and HA2 subunits E47K, S124N, and E172K.
Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza.
Review
Rappuoli et al., Siena, Italy. In Expert Opin Biol Ther, 2013
Finally, the MF59 changes the pattern of HA recognition by antibodies that react with the HA1 more than with the HA2 region.
HA2 glycopolypeptide of influenza A virus and antiviral immunity.
Review
Kostolanský et al., Bratislava, Slovakia. In Acta Virol, 2012
From this point of view recent attention has also been focused on the conserved part of HA, its HA2 glycoprotein (HA2).
DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.
Impact
Liu et al., Houston, United States. In Immunity, 2011
Although DDX1 bound poly I:C via its Helicase A domain, DHX36 and DDX21 bound the TIR domain of TRIF via their HA2-DUF and PRK domains, respectively.
Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation.
GeneRIF
Yang et al., Taipei, Taiwan. In Clin Chem Lab Med, 2010
the information on allele and genotype frequencies of HA-1 and HA-2 in a Taiwanese population
Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH).
GeneRIF
Shaw et al., Bethesda, United States. In J Biol Chem, 2010
Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain
Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs.
GeneRIF
Hmida et al., Tunisia. In Immunol Invest, 2009
gene polymorphism does not have any significant effect on the occurrence of GVHD in Tunisia
Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development.
Review
Varečková et al., Bratislava, Slovakia. In Virol J, 2009
Antigenically conserved fusion-active subunit of hemagglutinin (HA2 gp) and ectodomain of matrix protein 2 (eM2) are promising candidates for preparation of broadly protective HA2- or eM2-based vaccine that may aid in pandemic preparedness.
Antibody recognition of a highly conserved influenza virus epitope.
Impact
Wilson et al., Los Angeles, United States. In Science, 2009
In contrast to other structurally characterized influenza antibodies, CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of HA1 and HA2.
Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.
Impact
Dowdy et al., San Diego, United States. In Nat Med, 2004
Using this information, we developed a transducible, pH-sensitive, fusogenic dTAT-HA2 peptide that markedly enhanced TAT-Cre escape from macropinosomes.
In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens.
Impact
Goulmy et al., Newcastle upon Tyne, United Kingdom. In Nat Med, 2002
Therefore, using a skin-explant assay we investigated the in situ activities of cytotoxic T lymphocytes (CTLs) specific for the ubiquitously expressed mHag H-Y and for the hematopoietic-restricted mHags HA-1 and HA-2.
Atomic structure of the ectodomain from HIV-1 gp41.
Impact
Wiley et al., Boston, United States. In Nature, 1997
These features, and the existence of a similar reversal of chain direction in the fusion pH-induced conformation of influenza virus HA2 and in the transmembrane subunit of Moloney murine leukaemia virus (Fig. 1a-d), suggest a common mechanism for initiating fusion.
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