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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Histone cluster 2, H4a

H4, histone H4, FO108
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, ACID, CAN, NOV, V1a
Papers using H4 antibodies
Electron capture dissociation mass spectrometric analysis of lysine-phosphorylated peptides
Supplier
Ek Pia et al., In Upsala Journal of Medical Sciences, 2009
... Human recombinant histone H4 was from New England Biolabs, UK ...
Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells.
Supplier
Ahmed Niyaz, In PLoS ONE, 2007
... and acetylated lysine 14 (H3S10P/K14Ac); histone H3 dimethylated at lysine 9 (dimeH3K9); total H3; and histone H4 acetylated at lysine 8 (H4K8Ac) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
The use of activated protein C in severe Plasmodium falciparum malaria
Supplier
Ho May et al., In The American Journal of Pathology, 2006
... Recombinant human histone H4 was purchased from New England Biolabs (Ipswich, MA) ...
Global analysis of patterns of gene expression during Drosophila embryogenesis.
Supplier
Carroll Jason, In PLoS Genetics, 2006
... TBP, TFIIB, Pol II, H4K16ac (sc8662, Santa Cruz), H4 (ab7311, Abcam), NSL1, MCRS2, NSL3 and ...
Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats
Supplier
Dillon Niall et al., In The EMBO Journal, 2005
... following antibodies were used in western blot analysis, ChIP and IF: α-histone H3 (Abcam ab1791), α-H4 (Upstate 07-108), α-H3K9me3/S10ph (Abcam ab5819) (peptide ELISA to ...
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Papers on H4
Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation.
New
Renz et al., Marburg an der Lahn, Germany. In Int Arch Allergy Immunol, Feb 2016
This method was then applied to assess H3 and H4 histone acetylation changes in cord blood (CB) samples from an established cohort of Australian children exposed in the fetal period to either very low or very high levels of maternal folate.
Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and their Modifications.
New
Garcia et al., In Acs Chem Biol, Feb 2016
UNASSIGNED: The nucleosome is an octamer containing DNA wrapped around one histone H3-H4 tetramer and two histone H2A-H2B dimers.
Epigenetic Regulation of the Blimp-1 Gene in B Cells Involves Bach2 and Histone Deacetylase 3.
New
Igarashi et al., Japan. In J Biol Chem, Feb 2016
We found that histone H3 and H4 around the Prdm1 intron 5 MARE were acetylated at higher levels in X63/0 plasma cells expressing Blimp-1 than in BAL17 mature B cells lacking its expression.
Streptomyces humi sp. nov., an actinobacterium isolated from soil of a mangrove forest.
New
Chan et al., Kuala Selangor, Malaysia. In Antonie Van Leeuwenhoek, Feb 2016
The predominant menaquinones were identified as MK-9(H8), MK-9(H6) and MK-9(H4).
The Genetic Diversity of Influenza A Viruses in Wild Birds in Peru.
New
Bausch et al., Bethesda, United States. In Plos One, Dec 2015
Through sampling and whole-genome sequencing of 31 AIVs from wild birds in Peru, we identified 10 HA subtypes (H1-H4, H6-H7, H10-H13) and 8 NA subtypes (N1-N3, N5-N9).
Histone modification and chromatin remodeling during NER.
Review
New
Reed et al., Cardiff, United Kingdom. In Dna Repair (amst), Dec 2015
In the latter case we also see a role for acetylation at histone H4.
Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks.
Review
New
Price et al., Boston, United States. In J Mol Biol, Dec 2015
H2A.Z removal at DSBs alters the acidic patch on the nucleosome surface, promoting acetylation of the H4 tail (by the NuA4-Tip60 complex) and shifting the chromatin to a more open structure.
Cherry-picked ligands at histamine receptor subtypes.
Review
New
Stark et al., Al `Ayn, United Arab Emirates. In Neuropharmacology, Dec 2015
UNASSIGNED: Histamine, a biogenic amine, is considered as a principle mediator of multiple physiological effects through binding to its H1, H2, H3, and H4 receptors (H1-H4Rs).
Epigenetics and Cytoprotection with Heat Acclimation.
Review
New
Horowitz, In J Appl Physiol, Nov 2015
HSP70/HSP90/HSF1 memory protocol demonstrated constitutive histone H4 acetylation on hsp70 and hsp90 promotors.
Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C.
New
Impact
Rando et al., Worcester, United States. In Cell, Aug 2015
Investigation of chromosome folding in mutants confirms roles for RSC, "gene looping" factor Ssu72, Mediator, H3K56 acetyltransferase Rtt109, and the N-terminal tail of H4 in folding of the yeast genome.
Subnucleosomal structures and nucleosome asymmetry across a genome.
Impact
Pugh et al., United States. In Cell, 2015
Genes are packaged into nucleosomal arrays, each nucleosome typically having two copies of histones H2A, H2B, H3, and H4.
Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.
Impact
Dynlacht et al., New York City, United States. In Nat Cell Biol, 2014
Foxk1/2 specifically recruits Sin3A-HDAC complexes to restrict acetylation of histone H4 and expression of critical autophagy genes.
The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis.
Review
Jin et al., Changchun, China. In Int J Mol Sci, 2014
Both complexes can acetylate histone H4 at lysine 16 (H4K16); however, the NSL complex possesses broader substrate specificity and can also acetylate histone H4 at lysines 5 and 8 (H4K5 and H4K8), suggesting the complexity of the intracellular functions of MOF.
Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA.
Impact
Zhuang et al., Cambridge, United States. In Nature, 2014
We find that ACF senses linker DNA length through an interplay between its accessory and catalytic subunits mediated by the histone H4 tail of the nucleosome.
Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.
Impact
Chavrier et al., Paris, France. In Science, 2014
NM23-H4, a mitochondria-specific NDPK, colocalized with mitochondrial dynamin-like OPA1 involved in mitochondria inner membrane fusion and increased GTP-loading on OPA1.
A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain.
GeneRIF
Almouzni et al., Paris, France. In Mol Cell, 2012
NASP balances the activity of the heat shock proteins Hsc70 and Hsp90 to direct H3-H4 for degradation by chaperone-mediated autophagy
Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1.
GeneRIF
Schang et al., Edmonton, Canada. In J Virol, 2011
H2B and H4 histones were mobilized during herpes simplex virus 1 infection and became available to bind to viral genomes.
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.
GeneRIF
Jane et al., Melbourne, Australia. In Nat Struct Mol Biol, 2009
Loss of the H4 arginine 3 methylation mark through short hairpin RNA-mediated knockdown of PRMT5 leads to reduced DNMT3A binding, loss of DNA methylation and gene activation.
Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.
GeneRIF
Yamada et al., Yokohama, Japan. In Biochemistry, 2005
deiminated residues were present in H2A (1-56) and H4 (1-52)
Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells.
GeneRIF
Stein et al., Worcester, United States. In Mol Cell Biol, 2003
assessed the functional coupling between chromatin organization and regulation of histone H4/n gene expression during HL-60 differentiation into the monocyte/macrophage lineage
More papers using H4 antibodies
ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data
Supplier
Brunet Anne et al., In Nature, 2004
... Histone H4 lysine 16 acetylation regulates cellular lifespan ...
Regulation of ROS signal transduction by NADPH oxidase 4 localization
Supplier
Keaney John F. et al., In The Journal of Cell Biology, 2004
... Anti-GRP78 was obtained from BD Biosciences, anticatalase and anti–histone H4 were obtained from Abcam, antivimentin was purchased from ...
A novel histone exchange factor, protein phosphatase 2Cγ, mediates the exchange and dephosphorylation of H2A–H2B
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Okawa Katsuya et al., In The Journal of Cell Biology, 2001
... min and then with rabbit polyclonal antibodies directed against hyperacetylated H4 (1:1,000; Upstate Biotechnology) or H4-trimethylated K20 (1:500; Abcam) in the same buffer ...
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