Scaffolding builds to reduce blood pressure.
Oxford, United Kingdom. In Sci Signal, 2013
In this issue of Science Signaling, Sonkusare et al. report that the scaffold protein AKAP150 is required for the kinase PKC and the calcium channel TRPV4 to enable receptor-mediated relaxation signaling.
London, United Kingdom. In Handb Exp Pharmacol, 2013
AKAP79/150) are important for TRPV1 phosphorylation.
CaV1.2 sparklets in heart and vascular smooth muscle.
Davis, United States. In J Mol Cell Cardiol, 2013
CaV1.2 sparklet activity is tightly regulated by a cohort of protein kinases and phosphatases that are targeted to specific regions of the sarcolemma by the anchoring protein AKAP150.
Local regulation of L-type Ca²⁺ channel sparklets in arterial smooth muscle.
Davis, United States. In Microcirculation, 2013
The activity of L-type Ca²⁺ channel sparklets varies regionally within a cell depending on the dynamic activity of a cohort of protein kinases and phosphatases recruited to L-type Ca²⁺ channels in the arterial smooth muscle sarcolemma in a complex coordinated by the scaffolding molecule AKAP150.