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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Histone cluster 1, H1b

H1, CLIC4, VPS45, Vps45p, H1.5
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, SM22alpha, Actin, HAD, ACID
Papers using H1 antibodies
Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type I diabetes.
Chatziantoniou Christos, In PLoS ONE, 2010
... The double stranded DNA was cloned between the Bam H1 and EcoR1 site of a self inactivating retroviral expression vector (RNAi-Ready-pSiren-RetroQ-TetH, Clontech) ...
Ontology-based meta-analysis of global collections of high-throughput public data
Madhani Hiten D., In PLoS Genetics, 2009
... H1 hESCs were plated on Matrigel (BD Biosciences)-coated plates, and maintained in ...
Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions.
Neylon Cameron, In PLoS ONE, 2008
... Louis, MO, USA), monoclonal anti-Nm23-H1 antibody and anti-tubulin from Santa Cruz Biotechnology (Santa Cruz, CA, USA), ...
Methods to detect apoptotic-like cell death in filamentous fungi.
Tyler Brett, In PLoS Pathogens, 2008
... wild type strain B05.10 and H1-GFP transgenic strain were used throughout ...
Greally John M et al., In Genome Biology, 2008
... H1 human ES cells (NIH code WA01 from Wicell Research Institute, Madison, WI, USA) were cultured on matrigel (BD Biosciences, San Diego, CA, USA), ...
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Papers on H1
CREB-binding protein contributes to the regulation of endocrine and developmental pathways in insect hemimetabolan pre-metamorphosis.
Belles et al., Barcelona, Spain. In Biochim Biophys Acta, Mar 2016
METHODS AND RESULTS: Functional genomics studies using RNAi have shown that CBP contributes to the regulation of feeding and ecdysis during the pre-metamorphic nymphal instar of the cockroach Blattella germanica and is involved in TGF-ß, ecdysone, and MEKRE93 pathways, contributing to the activation of Kr-h1 and E93 expression.
Relaxed chromatin formation and weak suppression of homologous pairing by the testis-specific linker histone H1T.
Kurumizaka et al., In Biochemistry, Feb 2016
An in vitro homologous-pairing assay revealed that H1T weakly inhibited RAD51/RAD54-mediated homologous pairing in chromatin, although the somatic H1 subtypes, H1.0, H1.1, H1.2, H1.3, H1.4, and H1.5, substantially suppressed it.
Molecular identity of cardiac mitochondrial chloride intracellular channel proteins.
Singh et al., Philadelphia, United States. In Mitochondrion, Feb 2016
In this study, we report the presence of unique dimorphic Chloride Intracellular Channel proteins (CLICs) namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart.
CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking.
Sung et al., New York City, United States. In Nat Commun, Dec 2015
Chloride intracellular channel 4 (CLIC4) is a mammalian homologue of EXC-4 whose mutation is associated with cystic excretory canals in nematodes.
Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.
Mazzanti et al., Milano, Italy. In Biochim Biophys Acta, Oct 2015
In light of this, a new protein family, the chloride intracellular channels (CLICs), could be a promising class of therapeutic targets for its intrinsic individualities: CLIC1 and CLIC4, in particular, not only are overexpressed in specific tumor types or their corresponding stroma but also change localization and function from hydrophilic cytosolic to integral transmembrane proteins as active ionic channels or signal transducers during cell cycle progression in certain cases.
The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics.
Robert et al., Illkirch-Graffenstaden, France. In Biochim Biophys Acta, Oct 2015
BACKGROUND: Linker histone H1 is a structural component of chromatin.
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.
Glennie et al., Leiden, Netherlands. In Cancer Cell, Feb 2015
Agonistic activity can be transferred from h2 to h1 by swapping their hinge and CH1 domains, and substitution of key hinge and CH1 cysteines generates homogenous h2 variants with distinct agonistic properties.
Methoprene-tolerant (Met) and Krüpple-homologue 1 (Kr-h1) are required for ovariole development and egg maturation in the brown plant hopper.
Wang et al., Hangzhou, China. In Sci Rep, 2014
We studied the roles of the JH receptor Met and the downstream transcription factor Kr-h1 in ovariole development and egg maturation.
Pathogenic mechanisms and clinical implications of congenital neutropenia syndromes.
Klein et al., München, Germany. In Curr Opin Allergy Clin Immunol, 2013
Furthermore, the identification of novel genetic defects associated with congenital neutropenia, such as VPS45 deficiency, broadens our understanding of neutrophil biology.
A congenital neutrophil defect syndrome associated with mutations in VPS45.
Somech et al., Bethesda, United States. In N Engl J Med, 2013
RESULTS: All seven affected children had homozygous mutations (Thr224Asn or Glu238Lys, depending on the child's ethnic origin) in VPS45, which encodes a protein that regulates membrane trafficking through the endosomal system.
Intracellular ion channels and cancer.
Szabò et al., Padova, Italy. In Front Physiol, 2012
The nuclear potassium channel Kv10.1 and the nuclear chloride channel CLIC4 as well as the endoplasmatic reticulum (ER)-located inositol 1,4,5-trisphosphate (IP3) receptor, the ER-located Ca(2+) depletion sensor STIM1 (stromal interaction molecule 1), a component of the store-operated Ca(2+) channel and the ER-resident TRPM8 are also mentioned.
Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice.
Yuspa et al., Bethesda, United States. In Am J Pathol, 2012
These results indicate that CLIC4 participates in skin healing and corneal wound reepithelialization through enhancement of epithelial migration by a mechanism that may involve a compromised TGF-beta pathway.
CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.
Yuspa et al., Bethesda, United States. In Carcinogenesis, 2012
Reduced CLIC4 expression and nuclear residence detected in cancer cells is associated with the altered redox state of tumor cells and the absence of detectable nuclear CLIC4 in cancers contributes to TGF-beta resistance and enhances tumor development.
Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.
Yuspa et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
Data suggest that iNOS-induced nuclear CLIC4 is an essential part of the macrophage deactivation program.
Male factor infertility: a relaxin effect on sperm parameters.
Fenner, In Nat Rev Urol, 2011
[review] This study not only clarifies the role of relaxin in sperm, but could also open avenues of research into its use in fertility treatment.
Allergy and the bone: unexpected relationships.
Adami et al., Verona, Italy. In Ann Allergy Asthma Immunol, 2011
DATA SOURCES: The major databases MEDLINE and Scopus were searched using the keywords bone metabolism, bone resorption, bone formation, antihistamines, h1 antagonist, leukotriene antagonist, and leukotriene modifier.
Heterozygous deletion at the RLN1 locus in a family with testicular germ cell cancer identified by integrating copy number variation data with phenome and interactome information.
Ottesen et al., Denmark. In Int J Androl, 2011
heterozygous loss at the RLN1 locus is not a genetic factor mediating high population-wide risk for testicular germ cell tumour, but do not exclude a contribution of this aberration in some cases of cancer
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.
Yuspa et al., Bethesda, United States. In Nat Cell Biol, 2009
These results newly identify Schnurri-2 and CLIC4 as modifiers of TGF-beta signalling through their stabilization of p-Smad2 and 3 in the nucleus.
Group-theoretical and geometrical considerations of the phase transition between the high-temperature polymorphs of quartz and tridymite.
Koch et al., Berlin, Germany. In Acta Crystallogr A, 2002
Only the Si framework is considered, and the transformation can be described as a deformation of a homogeneous sphere packing with three contacts per sphere (type 3/10/h1) in the common subgroup P6(1)22 of P6(4)22 and P6(3)/mmc.
DNA sequence organization of the beta-globin complex in the BALB/c mouse.
Edgell et al., In Cell, 1980
The order of these genes is: 5'-epsilon y3-beta h0-beta h1-beta h2-beta h3-beta major-beta minor-3' Portions of each of the five newly identified genes have been sequenced.
More papers using H1 antibodies
The impact of microRNAs on protein output.
Lako Majlinda, In PLoS ONE, 2007
... Human ESCs (H1 and H9 cell lines, WiCell, Madison, WI, passage 35–40; BG01V line, ATCC, Manassas, VA) were routinely cultured in mTeSR-1 medium (Stemcell Technologies, Vancouver, Canada) using cell ...
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Ridley Anne J. et al., In Open Biology, 2005
... ERK (K-23, Santa Cruz), α-tubulin (DM1A clone, Sigma), rabbit polyclonals Pak1, p-Pak1(Ser199/204), p-Src(Tyr416), p-Paxilin(Tyr118) and GEF-H1 (Cell Signaling), mouse monoclonal Src and ...
Automated identification and quantification of protein phosphorylation sites by LC/MS on a hybrid triple quadrupole linear ion trap mass spectrometer
Muqit Miratul M. K. et al., In Open biology, 2005
... Bovine myelin basic protein and bovine casein were from Sigma (St Louis, MO), bovine histone H1 was from Abcam (Cambridge, UK) ...
Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with Endophilin A in response to epidermal growth factor.
Heisenberg Carl-Philipp, In PLoS ONE, 2002
... RNAi constructs directed against rat Abp1 the following oligonucleotides were annealed and subcloned into pRNAT H1.1-GFP (GenScript), Abp1 RNAi sequence #1: ...
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
Sarkar Devanand, In PLoS ONE, 1998
... Fluorescein isothiocyanate-, phycoerythrin-, allophycocyanin-, PerCP- or APC-Cy7-conjugated anti-mouse mAbs to CD3 (145-2C11), CD4 (RM4-5), CD69 (H1.2F3) and CD8a (53-6.7)
Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
Chen J H et al., In Oncogene, 1998
... GEF-H1 expression plasmid was obtained from ORIGENE (Rockville, MD, USA) (SC323957) ...
Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers
Hsieh Tze-chen et al., In Journal of Hematology and Oncology, 1997
... anti-cyclin B1, anti-cyclin D, anti-cyclin E, anti-cdk1, anti-cdk2, anti-AIF, anti-cytochrome c, anti-bcl-2, anti-bax, anti-actin, anti-histone H1, and secondary antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Use of an oriented peptide library to determine the optimal substrates of protein kinases
Yang Fuquan et al., In Journal of Biomedicine and Biotechnology, 1993
... Cyclin-Dependent Kinase-1(CDK1) and human histone H1 were purchased from New England BioLabs, Inc ...
Differences in evolutionary stability among mammalian H1 subtypes. Implications for the roles of H1 subtypes in chromatin.
Malik Harmit S., In PLoS Genetics, 1983
... Images of H1 KD cell lines grown in normal conditions were taken using an inverted Leica DMR microscope.
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