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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Phospholipase A2, group XVI

H-rev107, H-REV107-1, HRASLS3, AdPLA
gene whose expression is suppressed by HRAS [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, p21, V1a, HAD, Insulin
Papers on H-rev107
Phospholipase A2 Isoforms as Novel Targets for Prevention and Treatment of Inflammatory and Oncologic Diseases.
New
Kaladhar et al., Miami, United States. In Curr Drug Targets, Aug 2015
Several isoforms of PLA2s exist; they are mainly divided into secretory PLA2s (sPLA2), cytosolic PLA2s (cPLA2), and calcium independent PLA2s (iPLA2), platelet activating factor-acyl hydrolase (PAF-AH), lysosomal PLA2 (LPLA2), adipose-specific PLA2 (AdPLA).
Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.
New
Ueda et al., Japan. In J Biol Chem, Aug 2015
Phospholipase A/acyltransferase (PLA/AT)-3 (also known as H-rev107 or AdPLA) was originally isolated as a tumor suppressor and was later shown to have phospholipase A1/A2 activity.
LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3.
Palczewski et al., Cleveland, United States. In Nat Chem Biol, 2015
Cellular uptake of vitamin A, production of visual chromophore and triglyceride homeostasis in adipocytes depend on two representatives of the vertebrate N1pC/P60 protein family, lecithin:retinol acyltransferase (LRAT) and HRAS-like tumor suppressor 3 (HRASLS3).
H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.
Lee et al., Taipei, Taiwan. In Plos One, 2014
H-rev107 is a member of the HREV107 type II tumor suppressor gene family and acts as a phospholipase to catalyze the release of fatty acids from glycerophospholipid. H-rev107 has been shown to play an important role in fat metabolism in adipocytes through the PGE2/cAMP pathway, but the detailed molecular mechanism underlying H-rev107-mediated lipid degradation has not been studied.
Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathway.
Tsai et al., Taipei, Taiwan. In J Biomed Sci, 2013
BACKGROUND: H-rev107, also called HRASLS3 or PLA2G16, is a member of the HREV107 type II tumor suppressor gene family.
Candidate gene expression affects intramuscular fat content and fatty acid composition in pigs.
Xu et al., Nanjing, China. In J Appl Genet, 2013
The IMF content and fatty acid composition of the Longissimus dorsi muscle were measured and correlated with candidate genes mRNA expression (AdPLA, ADRB3, LEPR, MC4R, PPARĪ³, PPARĪ±, LPL, PEPCK, and SCD).
H-rev107 regulates prostaglandin D2 synthase-mediated suppression of cellular invasion in testicular cancer cells.
Tsai et al., Taipei, Taiwan. In J Biomed Sci, 2012
BACKGROUND: H-rev107 is a member of the HREV107 type II tumor suppressor gene family which includes H-REV107, RIG1, and HRASLS.
Involvement of the prostaglandin D2 signal pathway in retinoid-inducible gene 1 (RIG1)-mediated suppression of cell invasion in testis cancer cells.
Tsai et al., Taipei, Taiwan. In Biochim Biophys Acta, 2012
Retinoid-inducible gene 1 (RIG1), also called tazarotene-induced gene 3, belongs to the HREV107 gene family, which contains five members in humans.
Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.
Moreno-Aliaga et al., Pamplona, Spain. In J Lipid Res, 2012
Furthermore, LA caused a significant inhibition of adipose-specific phospholipase A2 (AdPLA) protein and mRNA levels in parallel with a decrease in the amount of prostaglandin E(2) released and an increase in cAMP content.
Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad.
Moise et al., Lawrence, United States. In J Biol Chem, 2012
Adipose phospholipase A(2) (AdPLA or Group XVI PLA(2)) plays an important role in the onset of obesity by suppressing adipose tissue lipolysis.
Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.
GeneRIF
Palczewski et al., Cleveland, United States. In J Biol Chem, 2012
Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT.
Haplotype combinations of AdPLA gene polymorphisms associate with growth traits in Chinese cattle.
Chen et al., China. In Mol Biol Rep, 2012
Ablation of AdPLA in mice could prevent obesity, which implicated AdPLA was a new candidate gene for growth traits.
Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107.
GeneRIF
Ueda et al., Japan. In J Biol Chem, 2012
H-rev107 interferes with the biosynthesis of ether-type lipids and is responsible for the dysfunction of peroxisomes in H-rev107-expressing cells.
Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.
GeneRIF
Sers et al., Eggenstein-Leopoldshafen, Germany. In Mol Cancer Res, 2010
role of PKC isoenzymes in PP2A and HRSL3(H-REV107-1) tumor suppressor-dependent cell death induction in ovarian carcinoma cell line; verified contribution to PP2A- and HRLS3-dependent apoptosis for PKCzeta suggesting a proapoptotic function of this kinase
Lipolysis in adipocytes.
Review
Sul et al., Berkeley, United States. In Int J Biochem Cell Biol, 2010
Furthermore, recent identification of AdPLA as the major adipose phospholipase A(2), has led to the discovery of a dominant autocrine/paracrine regulation of lipolysis through PGE(2).
The skinny on fat: lipolysis and fatty acid utilization in adipocytes.
Review
Sul et al., Berkeley, United States. In Trends Endocrinol Metab, 2009
Recent findings have identified a bona fide TAG hydrolase and the major adipose phospholipase A(2), AdPLA.
Adipose-specific phospholipase as regulator of adiposity.
Review
Wolf, Berkeley, United States. In Nutr Rev, 2009
A white adipose-tissue-specific intracellular phospholipase, which releases arachidonic acid from position sn-2 of phospholipids, was recently discovered and named AdPLA.
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
Impact
GeneRIF
Sul et al., Berkeley, United States. In Nat Med, 2009
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation.
GeneRIF
Tontonoz et al., Los Angeles, United States. In J Lipid Res, 2008
HRASLS3 as one of the downstream effectors of PPARgamma action in adipogenesis.
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