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H3 histone, family 3B

H-3, H3.3B, H3 histone family 3B
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is poyadenylated, unlike most histone genes. The protein encoded is a member of the histone H3 family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, ACID, H1, CAN, c-Myc
Papers on H-3
Identification of genes and pathways associated with osteoarthritis by bioinformatics analyses.
Lian et al., Fuzhou, China. In Eur Rev Med Pharmacol Sci, 2014
The platelet-derived growth factor receptor, beta polypeptide (PDGFRB), interferon, gamma (IFNG), early growth response 1 (EGR1), Fas ligand (TNF superfamily, member 6) (FASLG), H3 histone, family 3B (H3.3B) (H3F3B) and so on had higher connectivity degree in the PPI networks.
Genome editing a mouse locus encoding a variant histone, H3.3B, to report on its expression in live animals.
Banaszynski et al., New York City, United States. In Genesis, 2014
The histone variant H3.3 has been associated with a number of early events including formation of the paternal pronucleus upon fertilization.
A microRNA signature differentiates between giant cell tumor derived neoplastic stromal cells and mesenchymal stem cells.
Depeweg et al., Heidelberg, Germany. In Cancer Lett, 2012
We could confirm the already known regulation of the apoptosis inhibitor API5 by miR-224 and could further identify three novel miR-224 target genes (SMAD5, SLMAP, H3.3B).
Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3.
Torres-Padilla et al., Illkirch-Graffenstaden, France. In Nat Cell Biol, 2010
Results demonstrate a role for a modifiable residue within a histone-variant-specific context during reprogramming and identifies a novel function for mammalian H3.3 in the initial formation of dsRNA-dependent heterochromatin.
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Hamiche et al., Illkirch-Graffenstaden, France. In Genes Dev, 2010
DAXX functions as a bona fide histone chaperone involved in the replication-independent deposition of H3.3
Analysis of genes expressed during porcine fetal pituitary development by suppressive subtraction hybridization.
Kato et al., Kawasaki, Japan. In J Reprod Dev, 2007
On the other hand, histone H3.3B, GTP-binding alpha-stimulatory subunit, stathmin and others were found as gene expression decreased.
Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition.
Zavadil et al., New York City, United States. In Cells Tissues Organs, 2006
Based on multiple models of disease-related EMT, we propose that Polycomb group epigenetic silencers and histone-lysine methyl-transferases EZH1 and EZH2 are candidate targets of H/E(spl)-mediated transcriptional repression, in a process accompanied by replacement of modified core histone H3 with de novo synthesized histone variant H3.3B.
Histone H3.3 deposition at E2F-regulated genes is linked to transcription.
Trouche et al., Toulouse, France. In Embo Rep, 2006
Results support the hypothesis that histone H3.3 is incorporated after disruption of nucleosomes mediated by transcription elongation.
Regulation of the expression of histone H3.3 by differential polyadenylation.
Hennig et al., Shanghai, China. In Genome, 2005
Previously we have shown that the 3' untranslated regions (UTRs) of the replacement histone genes H3.3.A and H3.3B of Drosophila melanogaster differ in their nucleotide sequences and have different polyadenylation sites.
Sexually dimorphic gene expression in the hypothalamus, pituitary gland, and cortex.
St-Amand et al., Québec, Canada. In Genomics, 2005
In pituitary gland, 43 transcripts are differentially expressed, including RAS guanyl-releasing protein 2 (cell signaling), ornithine transporter (mitochondrial transport), H3 histone family 3B (chromatin structure), heterogeneous nuclear ribonucleoprotein U (chromatin remodeling), NADH dehydrogenase (mitochondrial oxidative phosphorylation), neuronatin (cell differentiation), and ribosomal protein S27a (protein metabolism).
Differential expression of human replacement and cell cycle dependent H3 histone genes.
Albig et al., Göttingen, Germany. In Gene, 2003
The H3 family includes two replacement histone genes, H3.3A and H3.3B, which both encode the same protein and are expressed independently from the cell cycle.
Radiation hybrid comparative mapping between human chromosome 17 and porcine chromosome 12 demonstrates conservation of gene order.
Tuggle et al., Ames, United States. In Anim Genet, 2001
The genes/ESTs were TATA box binding protein-associated factor (TAF2N/RBP56), alpha-2-plasmin inhibitor (SERPINF2/PLI), H3 histone family 3B (H3F3B), aminopeptidase puromycin sensitive (NPEPPS), an expressed sequence tag (ESTMI015) and P311 protein (P311).
Isolation, characterization, and mapping of four novel polymorphic markers and an H3.3B pseudogene to chromosome 9p21-22.
Martignetti et al., New York City, United States. In J Hum Genet, 1998
Moreover, we have identified a retroposon-rich area within this oncogenic region containing a processed H3.3B pseudogene flanked by an L1 sequence and an Alu element.
Mapping of FASN and ACACA on two chicken microchromosomes disrupts the human 17q syntenic group well conserved in mammals.
Vignal et al., France. In Mamm Genome, 1998
Although synteny is not conserved between these two genes, our results revealed linkage in chicken between FASN and NDPK (nucleoside diphosphate kinase), a homolog to the human NME1 and NME2 genes (non-metastatic cell proteins 1 and 2), both located on human Chr 17q21.3, and also between FASN and H3F3B (H3 histone family 3B), located on human Chr 17q25.
cAMP/phorbol ester response element is involved in transcriptional regulation of the human replacement histone gene H3.3B.
Doenecke et al., Göttingen, Germany. In Biochem J, 1998
The human histone H3.3B gene belongs to the group of replacement histone genes, which are up-regulated during differentiation of cells.
Differential expression of the murine histone genes H3.3A and H3.3B.
Doenecke et al., Göttingen, Germany. In Differentiation, 1997
In an attempt to define patterns of replacement histone H3.3 gene expression during male germ cell differentiation, we have constructed mouse testicular cDNA libraries and have isolated cDNAs corresponding to the murine H3.3A and H3.3B genes.
Transcriptional regulation of the human replacement histone gene H3.3B.
Doenecke et al., Göttingen, Germany. In Febs Lett, 1997
We have investigated the transcriptional regulation of the recently characterized human replacement histone gene H3.3B.
H3.3A variant histone mRNA containing an alpha-globin insertion: modulated expression during mouse gametogenesis correlates with meiotic onset.
Del Mazo et al., Madrid, Spain. In Dna Cell Biol, 1997
Replacement-variant H3.3 histones have been isolated and sequenced in different eukaryotes, but no functional H3.3A gene has been characterized in the mouse so far.
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