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Inter-alpha-trypsin inhibitor heavy chain 2

H-2p, SHAP, ITIH2, KIAA1202, IGHEP2, Shroom4
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, MHC, histamine H2 receptor, HAD, ACID
Papers on H-2p
Identification of novel genetic causes of Rett syndrome-like phenotypes.
New
Maciel et al., Guimarães, Portugal. In J Med Genet, Feb 2016
deletion encompassing four exons of the TCF4 gene and a mosaic UPD of chromosome 3. Variants in genes previously implicated in neurodevelopmental disorders (NDD) were identified in six patients (32%): de novo variants in EEF1A2, STXBP1 and ZNF238 were found in three patients, maternally inherited X linked variants in SLC35A2, ZFX and SHROOM4 were detected in two male patients and one homozygous variant in EIF2B2 was detected in one patient.
Genotype-phenotype characterization in 13 individuals with chromosome Xp11.22 duplications.
New
Chen et al., Canada. In Am J Med Genet A, Jan 2016
In total, we have collected data on nine individuals with duplications overlapping the distal duplication region containing SHROOM4 and DGKK and eight individuals overlapping the proximal region including HUWE1.
Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray.
New
Hu et al., Beijing, China. In Lab Chip, Jan 2016
Novel affinity peptide sequences H1P (HER1 ligand) and H2P (HER2 ligand) were determined with nmol affinity.
Formation of a Bridging Phosphinidene Thorium Complex.
New
Walensky et al., Columbia, United States. In J Am Chem Soc, Jan 2016
The reaction of 2 equiv of (C5Me5)2Th(CH3)2 with H2P(2,4,6-(i)Pr3C6H2) at 95 °C produces [(C5Me5)2Th]2(μ2-P[(2,6-CH2CHCH3)2-4-(i)PrC6H2] as well as 4 equiv of methane, 2 equiv from deprotonation of the phosphine and 2 equiv from C-H bond activation of one methyl group of each of the isopropyl groups at the 2- and 6-positions.
Development of Diagnostic Biomarkers for Detecting Diabetic Retinopathy at Early Stages Using Quantitative Proteomics.
New
Kim et al., Seoul, South Korea. In J Diabetes Res, Dec 2015
Although further validation with a larger sample size is needed, the 4-protein marker panel (APO4, C7, CLU, and ITIH2) could represent a useful multibiomarker model for detecting the early stages of DR.
Acute and temporal expression of tumor necrosis factor (TNF)-α-stimulated gene 6 product, TSG6, in mesenchymal stem cells creates microenvironments required for their successful transplantation into muscle tissue.
New
Kimata et al., Nagoya, Japan. In J Biol Chem, Oct 2015
Immunofluorescent staining showed that HA and IαI always co-localized or were distributed closely, suggesting formation of covalent complexes, i.e. the SHAP-HA complex in the presence of TSG6.
Interrogating protonated/deuterated fibronectin fragment layers adsorbed to titania by neutron reflectivity and their concomitant control over cell adhesion.
New
van der Walle et al., Glasgow, United Kingdom. In J R Soc Interface, Jul 2015
Similarly, the surface fraction of the more stable mutant (FIII9'10-H2P) was 34% and 18% for the deuterated and protonated forms, respectively.
Synthesis and photophysical properties of new catenated electron donor-acceptor materials with magnesium and free base porphyrins as donors and C60 as the acceptor.
New
Schuster et al., Erlangen, Germany. In Nanoscale, Feb 2015
A new series of nanoscale electron donor-acceptor systems with [2]catenane architectures has been synthesized, incorporating magnesium porphyrin (MgP) or free base porphyrin (H2P) as electron donor and C60 as electron acceptor, surrounding a central tetrahedral Cu(I)-1,10-phenanthroline (phen) complex.
Phenotype-genotype correlations in 17 new patients with an Xp11.23p11.22 microduplication and review of the literature.
Review
Malan et al., Paris, France. In Am J Med Genet A, 2015
Atypical microduplications allowed us to identify minimal critical regions that might be responsible for specific clinical findings of the syndrome and to suggest possible candidate genes: FTSJ1 and SHROOM4 for intellectual disability along with PQBP1 and SLC35A2 for epilepsy.
Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome.
Roberts et al., Adelaide, Australia. In Plos One, 2014
Other differentially expressed genes in Vdr-/- placentae included those involved in RNA modification (Snord123), autophagy (Atg4b), cytoskeletal modification (Shroom4), cell signalling (Plscr1, Pex5) and mammalian target of rapamycin (mTOR) signalling (Deptor and Prr5).
Double Xp11.22 deletion including SHROOM4 and CLCN5 associated with severe psychomotor retardation and Dent disease.
Tosca et al., Clamart, France. In Mol Cytogenet, 2014
BACKGROUND: Here we report the clinical and molecular characterization of two Xp11.22 deletions including SHROOM4 and CLCN5 genes.
Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing.
Piton et al., Illkirch-Graffenstaden, France. In J Med Genet, 2014
We also bring additional supportive (HCFC1, MED13L) or unsupportive (SHROOM4, SRPX2) evidences for the implication of previous candidate genes or mutations in cognitive disorders.
Influence of Hydrogen Bonds on the P···P Pnicogen Bond.
Del Bene et al., Madrid, Spain. In J Chem Theory Comput, 2012
Thus, the complex 3FH:(PH2F)2 acquires ion-pair character represented as [3(FH)F(-):(H2P-PH2F)(+)], and the P···P pnicogen bond acquires significant covalent character.
[Covalent complex of hyaluronan and serum-derived protein, SHAP is a functional molecule involved in inflammation: finding, structure, formation mechanism, and function of the complex].
Review
GeneRIF
Kimata, Japan. In Seikagaku, 2010
It forms complex with hyaluronan and the comlex is a functional molecule involved in inflammation.
Role of serum-derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer.
GeneRIF
Wakatsuki et al., Japan. In Oncol Rep, 2008
serum-derived hyaluronan-associated protein-hyaluronan complex has a role in progression of ovarian cancer
Hyaluronan (HA) and serum-derived hyaluronan-associated protein (SHAP)-HA complex as predictive markers of cervical ripening in premature labor.
GeneRIF
Kimata et al., Japan. In Connect Tissue Res, 2007
Increased levels of SHAP-HA complex in sera are possible predictive markers for cervical ripening in premature labor.
SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum.
GeneRIF
Kimata et al., Japan. In J Biol Chem, 2006
Leukocytes infiltrated to the synovium were strongly positive for hyaluronic acid, SHAP, and CD44 on their surfaces, suggesting a role for the adhesion-enhancing effect of SHAP in inflammation.
Characterization of complexes formed between TSG-6 and inter-alpha-inhibitor that act as intermediates in the covalent transfer of heavy chains onto hyaluronan.
GeneRIF
Day et al., Oxford, United Kingdom. In J Biol Chem, 2005
TSG-6 acts as cofactor and catalyst in the production of IalphaI heavy chain x hyaluronan complexes
A physiological function of serum proteoglycan bikunin: the chondroitin sulfate moiety plays a central role.
Review
Kimata et al., Japan. In Glycoconj J, 2002
In the presence of yet unidentified factors, the side proteins are transferred from chondroitin sulfate to hyaluronan by a transesterification reaction to form what has been described as the Serum-derived Hyaluronan-Associated Protein (SHAP)-hyaluronan complex.
Phosphinic acid compounds in biochemistry, biology and medicine.
Review
Jirácek et al., Praha, Czech Republic. In Curr Med Chem, 2000
Phosphinic acid compounds (phosphinates) are derivatives of phosphinic acid H2P(O)(OH).
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