Structure of Human DROSHA.
Seoul, South Korea. In Cell, Feb 2016
DROSHA functions together with its cofactor DGCR8 in a heterotrimeric complex known as Microprocessor.
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Jacksonville, United States. In Nat Cell Biol, Sep 2015
Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-transformed polarized epithelial cells: one growth suppressing at the apical zonula adherens (ZA), defined by the p120 partner PLEKHA7 and a non-nuclear subset of the core microprocessor components DROSHA and DGCR8, and one growth promoting at basolateral areas of cell-cell contact containing tyrosine-phosphorylated p120 and active Src.
Functional Anatomy of the Human Microprocessor.
Seoul, South Korea. In Cell, Jul 2015
MicroRNA (miRNA) maturation is initiated by Microprocessor composed of RNase III DROSHA and its cofactor DGCR8, whose fidelity is critical for generation of functional miRNAs.
N6-methyladenosine marks primary microRNAs for processing.
New York City, United States. In Nature, Apr 2015
The first step in the biogenesis of microRNAs is the processing of primary microRNAs (pri-miRNAs) by the microprocessor complex, composed of the RNA-binding protein DGCR8 and the type III RNase DROSHA.
Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population.
Warsaw, Poland. In Biomed Res Int, 2014
Nine polymorphisms of pre-miRNA processing genes, DROSHA (rs6877842), DGCR8 (rs3757, rs417309, and rs1640299), RAN (rs14035), XPO5 (rs11077), DICER1 (rs13078 and rs3742330) and TARBP2 (rs784567), were performed by TaqMan SNP Genotyping Assay.
TRAIL mediated signaling in pancreatic cancer.
Santa Maria, Brazil. In Asian Pac J Cancer Prev, 2013
It has been shown that DR5 interacts with the core microprocessor components Drosha and DGCR8, thus impairing processing of primary let-7.
MicroRNA Machinery Genes as Novel Biomarkers for Cancer.
Wuhan, China. In Front Oncol, 2013
To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs.
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.
Edinburgh, United Kingdom. In Nat Struct Mol Biol, 2012
DGCR8-mediated cleavage of snoRNAs was independent of Drosha, suggesting the involvement of DGCR8 in cellular complexes with other endonucleases. Binding of DGCR8 to cassette exons is a new mechanism for regulation of alternatively spliced isoforms.