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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phospholipase A2, group XIIA

GXII, Rossy, GXII-1, group XII secreted phospholipase A2, sPLA2-XII, PLA2G12A
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: AGE, V1a, HAD, PLA2, POLYMERASE
Papers on GXII
Investigation of Japanese-specific alleles: most are of Jomon lineage.
Ishikawa et al., Yonago, Japan. In Leg Med (tokyo), 2015
In this study, three single nucleotide polymorphisms (SNPs) in the GALNT11, H19, and PLA2G12A genes were analyzed in 2396 DNA samples from 25 global populations, and the derived alleles suggested that Japanese-specific alleles exist on autosomes.
Population history and genomic signatures for high-altitude adaptation in Tibetan pigs.
Ren et al., Nanchang, China. In Bmc Genomics, 2013
These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.
Conservation of group XII phospholipase A2 from bacteria to human.
Cardoso et al., Turku, Finland. In Comp Biochem Physiol Part D Genomics Proteomics, 2012
Vertebrate group XII phospholipases A(2) (GXII PLA(2), conserved domain pfam06951) are proteins with unique structural and functional features within the secreted PLA(2) family.
A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation.
Correia et al., Worcester, United States. In Mabs, 2012
Here, we describe use of a high throughput capillary electrophoresis based microfluidic device (LabChip GXII) to obtain pharmacokinetics (PK) of a fluorescently labeled human mAb directly from serum.
Conserved domains and evolution of secreted phospholipases A(2).
Riikonen et al., Turku, Finland. In Febs J, 2012
Pfam06951 (GXII PLA(2) ) is present in bacteria and is widely distributed in eukaryotes.
Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration.
Tuo et al., Bethesda, United States. In Mol Vis, 2011
For rs2285714 (PLA2G12A), the frequency of minor allele T was 40.1% for good responders compared to 51.7% for poor responders (odds ratio: 1.60, 95% confidence interval of odds ratio: 0.87-2.94,
Optical techniques for imaging membrane domains in live cells (live-cell palm of protein clustering).
Gaus et al., Sydney, Australia. In Methods Enzymol, 2011
While the method is applicable to a wide variety of proteins in various biological systems, to illustrate the technique, we will image and analyze the clustering behavior of the adaptor protein Linker for activation of T cells (LAT) at the T cell immunological synapse [Williamson, D. J., Owen, D. M., Rossy, J., Magenau, A., Wehrmann, M., Gooding, J. J. , and Gaus, K. (2011).
Low molecular weight phospholipases A2 in mammalian brain and neural cells: roles in functions and dysfunctions.
Nardicchi et al., Perugia, Italy. In Mol Neurobiol, 2010
Indeed, mRNAs for GIB, GIIA, GIIE, GIII, GV, GX, and GXII were detected in brain tissues despite different levels.
Pretreatment with a traditional Chinese formula, guanxin II, reduces cardiac apoptosis via the Akt survival pathway in rats with myocardial ischemia.
Zhou et al., Changsha, China. In Tohoku J Exp Med, 2010
Guanxin II (GXII) is a traditional Chinese formula to treat coronary heart disease in China.
Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci.
Lothe et al., Oslo, Norway. In Mol Cancer, 2009
Seven of these genes, CLC, EIF4E, LTBP4, PLA2G12A, PPAT, RG9MTD2, and ZNF574, had significantly different mRNA expression comparing median expression levels across the transcriptome between the two groups.
Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.
Lambeau et al., Antibes, France. In Br J Cancer, 2008
In normal colon, PLA2G2A and PLA2G12A were expressed at high levels, PLA2G2D, PLA2G5, PLA2G10 and PLA2G12B at moderate levels, and PLA2G1B, PLA2G2F and PLA2G3 at low levels.
Professor Hassan K. Awwad; The Father of Radiation Oncology and Radiobiology in Egypt and the Arab World, His Good Deeds Last Forever and Inspire us for the Future.
Abd Elbaky et al., Cairo, Egypt. In J Egypt Natl Canc Inst, 2007
The International Atomic Energy Agency (IAEA) awarded him fellowships in France (Institute Gustave Rossy) to gain experience in brachytherapy in 1956 and 1971, England 1956, 1959.
The clinical role of phospholipase A2 isoforms in advanced-stage ovarian carcinoma.
Reich et al., Oslo, Norway. In Gynecol Oncol, 2006
For patients with post-chemotherapy effusions, FIGO stage IV and higher PLAP mRNA expression correlated with worse OS (p=0.005 for both PLAP and stage), while higher PLAP (p=0.025) and sPLA2-XII (p=0.027)
Induction of ectopic olfactory structures and bone morphogenetic protein inhibition by Rossy, a group XII secreted phospholipase A2.
Brivanlou et al., New York City, United States. In Mol Cell Biol, 2005
We present evidence that Rossy/sPLA(2)-gXII can inhibit the transcriptional activation of BMP direct-target gene reporters in Xenopus and mouse P19 embryonic carcinoma cells through the loss of DNA-binding activity of activated Smad1/4 complexes.
Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity.
Lambeau et al., Antibes, France. In Biochemistry, 2003
The mature protein has a molecular mass of 19.7 kDa and structural features similar to those of the previously identified GXII sPLA(2), now called GXIIA.
Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).
Kudo et al., Tokyo, Japan. In J Biol Chem, 2003
cellular arachidonate (AA) release and prostaglandin (PG) production are regulated by novel classes of secretory phospholipase A(2)s (sPLA(2)s), groups III and XII
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