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Phosphatidylinositol glycan anchor biosynthesis, class W

GWT1, PIG-W, Gwt1p
Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).[supplied by OMIM, Mar 2008] (from NCBI)
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Top mentioned proteins: V1a, CAN, FLIP, HAD, ACID
Papers on GWT1
GWT1 encoding an inositol acyltransferase homolog is required for laccase repression and stress resistance in the basidiomycete Cryptococcus neoformans.
Zhu et al., Tianjin, China. In Fems Yeast Res, Dec 2015
In this study, we found that a GWT1 gene that encodes a glycosylphosphatidylinositol (GPI) anchor biosynthesis-related protein is required for laccase repression by glucose in the basidiomycete C. neoformans.
Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.
Lindquist et al., Cambridge, United States. In Acs Chem Biol, 2012
Here, we report the discovery of a new small molecule christened gepinacin (for GPI acylation inhibitor) which selectively inhibits Gwt1, a critical acyltransferase required for the biosynthesis of fungal GPI anchors.
E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis.
Hata et al., Tsukuba, Japan. In Antimicrob Agents Chemother, 2012
protein, Aspergillus fumigatus GWT1 (AFUA_1G14870) protein, and human PIG-W protein, which can catalyze the inositol acylation of GPI early in the GPI biosynthesis pathway, and then we assessed the effects of E1210 on key C. albicans virulence factors.
Analysis of membrane topology and identification of essential residues for the yeast endoplasmic reticulum inositol acyltransferase Gwt1p.
Jigami et al., Tsukuba, Japan. In J Biol Chem, 2011
analysis of essential residues of PIG-W and Gwt1p and membrane topology of Gwt1p
Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives.
Hata et al., Tsukuba, Japan. In Bioorg Med Chem Lett, 2010
Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway.
Babesia bovis contains an abundant parasite-specific protein-free glycerophosphatidylinositol and the genes predicted for its assembly.
Florin-Christensen et al., Argentina. In Vet Parasitol, 2010
The potential of B. bovis to assemble the presented free GPI species was verified by the existence of seven genes in its genome that putatively encode the following GPI biosynthetic enzymes: PI N-acetyl-GlcN-transferase (PIG-A and GPI-1), N-acetyl-GlcN-PI-de-N-acetylase (PIG-L), acyltransferase (PIG-W), dolichyl-phosphate mannosyl transferase (DPM-1), GPI mannosyltransferase I (PIG-M), and GPI mannosyltransferase II (PIG-V).
[Biosynthetic pathway of GPI-anchored cell wall mannoproteins in yeast as a potential target for anti-fungal and anti-cancer drugs].
Jigami, Tsukuba, Japan. In Nihon Ishinkin Gakkai Zasshi, 2007
We identified GWT1 as a new anti-fungal drug candidate target and elucidated its function as being involved in the acylation of the inositol ring.
Glycosylphosphatidylinositol-anchored proteins are required for the transport of detergent-resistant microdomain-associated membrane proteins Tat2p and Fur4p.
Jigami et al., Tsukuba, Japan. In J Biol Chem, 2006
We previously isolated gwt1 mutants and found that GWT1 is required for inositol acylation in the GPI biosynthetic pathway.
[New approach to reveal genes that control cell wall biogenesis of the yeast Saccharomyces cerevisiae].
Ter-Avanesian et al., In Mol Biol (mosk), 2005
They were MNN9 which encodes protein involved in formation of outer chains of the N-linked glycans of secretory proteins and GWT1, encoding the protein of the endoplasmic reticulum involved in the glycosylphosphatidylinositol biosynthesis.
Use of Clostridium septicum alpha toxins for isolation of various glycosylphosphatidylinositol-deficient cells.
Hong et al., Kwangju, South Korea. In J Microbiol, 2005
By genetic complementation, we determined that one mutant cell was defective of the second subunit of dolichol phosphate mannose synthase (DPM2) and other five cells were of a putative catalytic subunit of inositol acyltransferase (PIG-W).
PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.
Kinoshita et al., Ōsaka, Japan. In Mol Biol Cell, 2003
Herein, we report derivation of human and Chinese hamster mutant cells defective in inositol acylation and the gene responsible, PIG-W.
GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast.
Jigami et al., Tsukuba, Japan. In J Biol Chem, 2003
We reported previously that the GWT1 gene product is a target of the novel anti-fungal compound, 1-[4-butylbenzyl]isoquinoline, that inhibits cell wall localization of GPI-anchored mannoproteins in Saccharomyces cerevisiae (Tsukahara, K., Hata, K., Sagane, K., Watanabe, N., Kuromitsu, J., Kai, J., Tsuchiya, M., Ohba, F., Jigami, Y., Yoshimatsu, K., and Nagasu, T. (2003) Mol.
Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly.
Nagasu et al., Tsukuba, Japan. In Mol Microbiol, 2003
A previously uncharacterized gene YJL091c, named GWT1, was cloned as a dosage-dependent suppressor of the BIQ-induced phenotypes.
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