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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Guanylate cyclase 1, soluble, alpha 3

GUCY1A3, GC-S alpha 3, GCS-A
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: AGE, CAN, PMCA1, SFRP1, Ccth
Papers on GUCY1A3
Disrupted Nitric Oxide Signaling due to GUCY1A3 Mutations Increases Risk for Moyamoya Disease, Achalasia and Hypertension.
New
Milewicz et al., London, United Kingdom. In Clin Genet, Feb 2016
Homozygous mutations in GUCY1A3 have been reported as a cause of MMD and achalasia.
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
New
Gu et al., Beijing, China. In Hum Mol Genet, Mar 2015
We also replicated 14 previously reported loci, 8 (CASZ1, MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 × 10(-3) to 5.16 × 10(-8).
α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.
Marletta et al., London, United Kingdom. In Circ Cardiovasc Genet, 2014
A novel missense mutation in GUCY1A3 in 3 subjects with a normal mean pulmonary artery pressure encodes an α1-A680T soluble guanylate cyclase (sGC) variant.
Moyamoya disease and syndromes: from genetics to clinical management.
Review
Kossorotoff et al., Paris, France. In Appl Clin Genet, 2014
Characteristics of genetic moyamoya syndromes are presented, with a focus on recently reported mutations in BRCC3/MTCP1 and GUCY1A3 genes.
Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.
Tournier-Lasserve et al., Paris, France. In Am J Hum Genet, 2014
This syndrome is associated in all three families with homozygous mutations in GUCY1A3, which encodes the α1 subunit of soluble guanylate cyclase (sGC), the major receptor for nitric oxide (NO).
Dysfunctional nitric oxide signalling increases risk of myocardial infarction.
Impact
Schunkert et al., Lübeck, Germany. In Nature, 2014
Here we report the segregation of two private, heterozygous mutations in two functionally related genes, GUCY1A3 (p.Leu163Phefs*24) and CCT7 (p.Ser525Leu), in an extended myocardial infarction family.
The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase.
GeneRIF
Martin et al., Houston, United States. In Biochem J, 2012
The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
Impact
Gu et al., Beijing, China. In Nat Genet, 2012
These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1.
Quaternary structure controls ligand dynamics in soluble guanylate cyclase.
GeneRIF
Negrerie et al., Palaiseau, France. In J Biol Chem, 2012
We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain.
Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration and down-regulation in prostate cancer.
GeneRIF
Shemshedini et al., Toledo, United States. In Mol Endocrinol, 2012
GCS-alpha-1 regulation of p53 activity is important in prostate cancer biology and may represent an important mechanism of p53 down-regulation.
A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase.
GeneRIF
Tan et al., Shanghai, China. In J Biol Inorg Chem, 2011
A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Impact
Johnson et al., In Nature, 2011
This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology.
Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC.
GeneRIF
Peter et al., Melbourne, Australia. In Atherosclerosis, 2011
analysis of pharmacological response to direct sGC activators in coronary artery disease patients
Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase.
Karsan et al., Vancouver, Canada. In Dev Cell, 2011
Here we show that Notch activation induces the transcription of both subunits of the soluble guanylyl cyclase (sGC) heterodimer, GUCY1A3 and GUCY1B3, which form the nitric oxide receptor.
Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells.
Fuentes et al., Cáceres, Spain. In Nitric Oxide, 2010
To better understand the actions of nitric oxide and its potential role in paraquat-induced gene expression, we examined changes in GCH1, ARG1, ARG2, NOS1, NOS2, NOS3, NOSTRIN, NOSIP, NOS1AP, RASD1, DYNLL1, GUCY1A3, DDAH1, DDAH2 and CYGB genes whose expression is controlled by or involved in signaling by the second messenger nitric oxide, in rat mesencephalic cells after 3, 6, 12 and 24h of paraquat exposure.
ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation.
Review
Hanash et al., New Orleans, United States. In Autoimmunity, 2008
In microarray experiments and real-time RT-PCR assays, we observed significant differences in RNA levels from ICF vs. control lymphoblasts for pro- and anti-apoptotic genes (BCL2L10, CASP1, and PTPN13); nitrous oxide, carbon monoxide, NF-kappaB, and TNFalpha signalling pathway genes (PRKCH, GUCY1A3, GUCY1B3, MAPK13; HMOX1, and MAP4K4); and transcription control genes (NR2F2 and SMARCA2).
Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation.
Mirnics et al., Pittsburgh, United States. In J Neurosci, 2007
One gene, guanylate cyclase 1 alpha 3 (GUCY1A3), showed differential expression between the 1 week and maternally reared groups and the 1 week and 1 month groups; these changes were confirmed by in situ hybridization.
Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers.
Ip et al., Buffalo, United States. In Mol Cancer Ther, 2005
Third, MSA inhibition of five androgen receptor-regulated genes implicated in prostate carcinogenesis (PSA, KLK2, ABCC4, DHCR24, and GUCY1A3) is significantly attenuated by androgen receptor overexpression.
Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3.
GeneRIF
Murakami et al., Tokyo, Japan. In Oncol Rep, 2004
Soluble guanylate cyclases could be the target molecules for controlling neo-vascularization in a subset of human malignant gliomas.
Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.
Guellaen et al., Créteil, France. In Hum Genet, 1993
The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S alpha 3 and beta 3 subunits, respectively.
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