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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Guanylate cyclase 1, soluble, alpha 2

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Papers on GUCIA2
Structural and functional insights into the heme-binding domain of the human soluble guanylate cyclase α2 subunit and heterodimeric α2β1.
Tan et al., Shanghai, China. In J Biol Inorg Chem, 2012
The CO binding affinity of soluble guanylate cyclase alpha 2 subunit is threefold greater than that of human soluble guanylate cyclase alpha 1 subunit.
Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation.
Murad et al., Houston, United States. In Nitric Oxide, 2010
The sGC alpha 1observed in OVCAR-3 and MDA-MB-468 cancer cells which correlated well with the sGC activity and a marked increase in cGMP levels upon exposure to the combination of a NO donor and a sGC activator.
Expression of nNOS and soluble guanylate cyclase in schizophrenic brain.
Emson et al., Tokyo, Japan. In Neuroreport, 2004
No significant changes were found in sGC subunit mRNAs in people with schizophrenia or in controls.
On the activation of soluble guanylyl cyclase by nitric oxide.
Garthwaite et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2002
Soluble guanylyl cyclase (sGC) is the major cellular receptor for the intercellular messenger nitric oxide (NO) and mediates a wide range of physiological effects through elevation of intracellular cGMP levels
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