Riociguat for the treatment of pulmonary hypertension.
Hamilton, Canada. In Expert Rev Respir Med, Dec 2015
NO activates soluble guanylate cyclase (sGC) resulting in the synthesis of cyclic guanosine monophosphate (cGMP) - a key mediator of pulmonary artery vasodilatation that may also inhibit smooth muscle proliferation and platelet aggregation.
[Octarphin--Nonopioid Peptide of the Opioid Origin].
In Bioorg Khim, Sep 2015
Taking into account that NO acts as a primary activator of soluble guanylate cyclase (sGC), it can be assumed that the activating effect of octarphin on macrophages is realized in the following way: increase in th iNOS expression --> increase in the NO production --> increase in the sGC activity --> increase in intracellular levels of cGMP.
Familial diarrhea syndrome caused by an activating GUCY2C mutation.
Bergen, Norway. In N Engl J Med, 2012
METHODS: We used linkage analysis, based on arrays with single-nucleotide polymorphisms, to identify a candidate region on chromosome 12 and then sequenced GUCY2C, encoding guanylate cyclase C (GC-C), an intestinal receptor for bacterial heat-stable enterotoxins.