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RAS guanyl releasing protein 3

guanine nucleotide exchange factor for Rap1, RASGRP3, KIAA0846
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Rap1, C3G, HAD, CAN, POLYMERASE
Papers on guanine nucleotide exchange factor for Rap1
Genome-wide association study of antibody responses to Plasmodium falciparum candidate vaccine antigens.
New
Courtin et al., Paris, France. In Genes Immun, Feb 2016
According to the strength of their observed associations and their functional role, the following genes are of particular interest: RASGRP3 (2p22.3,
Gene polymorphisms and oral cancer risk in tobacco habitués.
New
Saranath et al., Mumbai, India. In Tumour Biol, Dec 2015
The SNPs rs2124437 (RASGRP3), rs1335022 (GRIK2), rs4512367 (PREX2), rs4748011 (CCDC3), and rs1435218 (LNX1) were analyzed in 500 histopathologically confirmed oral cancers and 500 healthy controls with a minimum of 10 years of tobacco usage.
Characterization of type I interferon pathway during hepatic differentiation of human pluripotent stem cells and hepatitis C virus infection.
New
Arumugaswami et al., Los Angeles, United States. In Stem Cell Res, Sep 2015
Subsequent validation confirmed the expression of novel ISGs including RASGRP3, CLMP and TRANK1 by differentiated hepatic cells upon IFN treatment.
Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer.
Li et al., Houston, United States. In Mol Cancer Res, 2015
From this genome-wide approach, mutations were found in a series of genes with prostate cancer relevance, including AR, NCOR1, KDM3A, KDM4A, CHD1, SETD5, SETD7, INPP4B, RASGRP3, RASA1, TP53BP1, and CDH1, and a novel SND1:BRAF gene fusion.
Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism.
Butler et al., Kansas City, United States. In Alcohol Clin Exp Res, 2014
RESULTS: Decreased mRNA expression was observed for genes involved in cellular adhesion (e.g., CTNNA3, ITGA2), transport (e.g., TF, ABCA8), nervous system development (e.g., LRP2, UGT8, GLDN), and signaling (e.g., RASGRP3, LGR5) with influence over lipid and myelin synthesis (e.g., ASPA, ENPP2, KLK6).
Upregulation of RASGRP3 expression in prostate cancer correlates with aggressive capabilities and predicts biochemical recurrence after radical prostatectomy.
Ye et al., Wuhan, China. In Prostate Cancer Prostatic Dis, 2014
BACKGROUND: This study was undertaken to investigate the expression of guanyl nucleotide-releasing protein for Ras 3 (RasGRP3) in the cell lines and tissues in BPH and prostate cancer (PCa), as well as its associations with cancer invasion and prognosis in prostate carcinomas.
Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis.
Fujisawa et al., Kōbe, Japan. In Biochem Biophys Res Commun, 2014
In the present study, we investigated the functional significance of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in testicular differentiation using mice lacking RA-GEF-2.
Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.
Geraci et al., Aurora, United States. In Cancer Prev Res (phila), 2014
Within these novel regions, losses of putative tumor suppressors (RNF20 and SSBP2) and an amplification of RASGRP3 gene with oncogenic activity were observed.
Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations.
Sandling et al., Uppsala, Sweden. In Eur J Hum Genet, 2013
The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts.
Protein kinase C epsilon and genetic networks in osteosarcoma metastasis.
Andrulis et al., Toronto, Canada. In Cancers (basel), 2012
The differentially activated PRKCε-RASGRP3-GNB2 network, which interacts with the disorganized DLG2 hub, was also found to be differentially expressed among OS cell lines with differing metastatic capacity in xenograft models.
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-Chantar et al., Spain. In Gastroenterology, 2012
Ras activation of LKB1 required expression of RAS guanyl releasing protein 3 (RASGRP3).
Genome-wide disease association study in chewing tobacco associated oral cancers.
Saranath et al., Mumbai, India. In Oral Oncol, 2012
Analysis using Kyoto Encyclopedia of Genes and Genome Pathway database, indicated SNP association with several genes including GRIK2, RASGRP3, CAMK4, SYK, RAPTOR, FHIT, DCC, active in signal transduction; MMP2, CNTNAP2, PTPRJ associated with tumor cell migration; and apoptotic gene IRAK3.
RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.
GeneRIF
Blumberg et al., Bethesda, United States. In Oncogene, 2011
The identification of the role of RasGRP3 in melanoma highlights its importance, as a Ras activator, in the phosphoinositide signaling pathway in human melanoma.
The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration.
GeneRIF
Bautch et al., Chapel Hill, United States. In Circ Res, 2011
Expressed in developing blood vessels, Rasgrp3 contributes to the incidence of cardiovascular defects found in embryos from diabetic mothers.
MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits.
Jeon et al., Seoul, South Korea. In Cell Prolif, 2011
miR-99a, miR-125b, miR-216a and miR-1296 were putative negative regulators of RASGRP3, GPR160, PRKCH and XAF1, respectively, which were found to be differentially expressed in LCLs during long-term culture in a previous study.
RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype.
GeneRIF
Blumberg et al., Bethesda, United States. In Cancer Res, 2010
RasGRP3 contributes to the malignant phenotype of prostate cancer cells and may constitute a novel therapeutic target for human prostate cancer.
TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population.
GeneRIF
Yang et al., China. In Lupus, 2010
Significant associations were found for the single nucleotide polymorphism rs13385731 of RasGRP3 with malar rash, discoid rash, and antinuclear antibody in patients with systemic lupus erythematosus
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
Impact
Zhang et al., In Nat Genet, 2009
We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23,
The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain.
GeneRIF
Lorenzo et al., Honolulu, United States. In J Biol Chem, 2006
dynein light chain 1 represents a novel anchoring protein for RasGRP3 that may regulate subcellular localization of the exchange factor
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