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Rac GTPase activating protein 1

GTPase-activating protein, MgcRacGAP
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: GAP, Rhodopsin, V1a, CAN, Actin
Papers on GTPase-activating protein
Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer.
New
Malfertheiner et al., Magdeburg, Germany. In Cancer Med, Feb 2016
There was a direct association of AURKA with Rac GTPase-activating protein 1 (RACGAP1), as well as with CTNBB1 (β-catenin) and CDKN1A as second-order interactors.
Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve.
New
Butcher et al., Ithaca, United States. In Curr Biol, Feb 2016
RhoA activity and its regulated GTPase-activating protein FilGAP are elevated during early cushion formation but decreased considerably during valve remodeling.
Zds1/Zds2-PP2ACdc55 complex specifies signaling output from Rho1 GTPase.
New
Yoshida et al., Kashiwa, Japan. In J Cell Biol, Feb 2016
Zds1/Zds2-PP2A(Cdc55) promotes polarized growth and cell wall synthesis by inhibiting Rho1 GTPase-activating protein (GAP) Lrg1 but inhibits CWI pathway by stabilizing another Rho1 GAP, Sac7, suggesting that active Rho1 is biased toward cell growth over stress response.
PI3K regulates endocytosis after insulin secretion via signaling crosstalk between Arf6 and Rab27a.
New
Kimura et al., Ōita, Japan. In J Cell Sci, Jan 2016
Here, we searched for Rab27a GTPase-activating protein (GAP) EPI64-interacting proteins and identified the Arf6 guanine-nucleotide-exchange factor (GEF) ARNO in pancreatic beta-cells.
Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM10.
New
Ohta et al., Japan. In Plos One, Dec 2015
FilGAP is a Rac-specific GTPase-activating protein (GAP) that suppresses lamellae formation.
Proteomics-Based Identification and Analysis of Proteins Associated with Helicobacter pylori in Gastric Cancer.
New
Guan et al., Guiyang, China. In Plos One, Dec 2015
We detected 135 differently expressed proteins from the three cell lines using proteome technology, and 10 differential proteins common to the three cell lines were selected and identified by LC-MS/MS as well as verified by western blot: β-actin, L-lactate dehydrogenase (LDH), dihydrolipoamide dehydrogenase (DLD), pre-mRNA-processing factor 19 homolog (PRPF19), ATP synthase, calmodulin (CaM), p64 CLCP, Ran-specific GTPase-activating protein (RanGAP), P43 and calreticulin.
A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor.
Review
New
Impact
Miller et al., Cincinnati, United States. In Nat Rev Cancer, May 2015
The NF1 gene encodes a RAS GTPase-activating protein called neurofibromin and is one of several genes that (when mutant) affect RAS-MAPK signalling, causing related diseases collectively known as RASopathies.
The Ras/Rap GTPase activating protein RASA3: from gene structure to in vivo functions.
Review
Molina-Ortiz et al., Liège, Belgium. In Adv Biol Regul, 2015
RASA3 (or GTPase Activating Protein III, R-Ras GTPase-activating protein, GAP1(IP4BP)) is a GTPase activating protein of the GAP1 subfamily which targets Ras and Rap1.
Physiology of RGS10 in Neurons and Immune Cells.
Review
Tansey et al., Atlanta, United States. In Prog Mol Biol Transl Sci, 2014
Regulator of G protein signaling-10 (RGS10), a GTPase-activating protein (GAP) for Gαi3, Gαq, and Gαz, belongs to the D/R12 subfamily based on the homology within the RGS domain and is one of the smallest RGS proteins, outside the RGS box.
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.
Impact
Cichowski et al., Boston, United States. In Nature, 2014
NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss drives cancer by activating Ras.
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.
Impact
Yamada et al., Bethesda, United States. In Nat Cell Biol, 2014
Mechanistically, collagen phospho-regulates βPix, leading to its association with srGAP1, a GTPase-activating protein (GAP), needed to suppress RhoA activity.
Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1.
Impact
Elefteriou et al., Nashville, United States. In Nat Med, 2014
NF1 is caused by mutations in the NF1 gene, which encodes the RAS GTPase-activating protein neurofibromin.
The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response.
Review
Sawa, Kyoto, Japan. In J Intensive Care, 2013
ExoS is a 49-kDa form of exoenzyme S, a bifunctional toxin that exerts ADP-ribosyltransferase and GTPase-activating protein (GAP) activity to disrupt endocytosis, the actin cytoskeleton, and cell proliferation.
Emerging roles of small GTPases in secondary cell wall development.
Review
Fukuda et al., Mishima, Japan. In Front Plant Sci, 2013
In differentiating xylem cells, a specific GTPase-activating protein (GAP)/guanine nucleotide exchange factor (GEF) pair facilitates local activation of ROP11 to establish de novo plasma membrane domains.
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
Impact
Walker et al., Houston, United States. In Nat Cell Biol, 2013
TSC1 and TSC2 were bound by peroxisomal biogenesis factors 19 and 5 (PEX19 and PEX5), respectively, and peroxisome-localized TSC functioned as a Rheb GTPase-activating protein (GAP) to suppress mTORC1 and induce autophagy.
Cooperative activation of PI3K by Ras and Rho family small GTPases.
GeneRIF
Heo et al., Taejŏn, South Korea. In Mol Cell, 2012
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities
Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma.
GeneRIF
Hui et al., Singapore, Singapore. In Clin Cancer Res, 2011
the level of RACGAP1 expression is sufficient to predict the early recurrence of HCC.
CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.
GeneRIF
Bertoglio et al., Châtenay-Malabry, France. In Mol Cell Biol, 2009
study reports that mitotic complex genes Ect2, RacGAP, and MKLP1 are coordinately induced in S phase in proliferating T lymphocytes as well as in epithelial cells, depending upon activity of the CUX1 and E2F1 transcription factors
Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.
GeneRIF
Prekeris et al., Aurora, United States. In Embo J, 2008
Study demonstrates that FIP3 and ECT2 form mutually exclusive complexes with Cyk-4 and that dissociation of ECT2 from the mid-body at late telophase may be required for the recruitment of FIP3 and recycling endosomes to the cleavage furrow.
Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase.
GeneRIF
Bertoglio et al., Paris, France. In Febs Lett, 2008
report here that (i) MgcRacGAP is phosphorylated by Aurora B and Cdk1, (ii) PP2A dephosphorylates Aurora B and Cdk1 phosphorylated sites and (iii) inhibition of PP2A abrogates MgcRacGAP/Ect2 interaction
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