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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

FOL2 Fol2p

GTP cyclohydrolase, FOL2
Top mentioned proteins: GTP cyclohydrolase I, ACID, CAN, iNOS, HAD
Papers on GTP cyclohydrolase
Enhancing the natural folate level in wine using bioengineering and stabilization strategies.
New
Kitts et al., Vancouver, Canada. In Food Chem, Apr 2016
We confirmed by overexpression that FOL2 was the key gene encoding the rate-limiting step of folate biosynthesis in wine yeast.
2-Acetyl-7-hydroxy-6-methoxy-1-methyl-1,2,3,4,-tetrahydroisoquinoline exhibits anti-inflammatory properties and protects the nigral dopaminergic neurons.
New
Hwang et al., Seoul, South Korea. In Eur J Pharmacol, Jan 2016
In lipopolysaccharide-activated BV-2 microglial cells, AMTIQ lowered nitric oxide and tetrahydrobiopterin levels and downregulated gene expression of inducible nitric oxide synthase and GTP cyclohydrolase I. AMTIQ also repressed gene expression of the proinflammatory cytokines IL-1β and TNF-α, and attenuated nuclear translocation of NF-κB.
Diverse mechanisms of post-transcriptional repression by the small RNA regulator of glucose-phosphate stress.
New
Vanderpool et al., Urbana, United States. In Mol Microbiol, Oct 2015
These new targets, asd, adiY, folE and purR, encode transcription factors or enzymes of diverse metabolic pathways, including aspartate semialdehyde dehydrogenase, arginine decarboxylase gene activator, GTP cyclohydrolase I and a repressor of purine biosynthesis, respectively.
Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase.
New
Li et al., Mainz, Germany. In J Geriatr Cardiol, Sep 2015
Treatment of human EA.hy 926 endothelial cells with dexamethasone decreased mRNA and protein expression of both BH4-synthesizing enzymes: GTP cyclohydrolase I and dihydrofolate reductase.
Dopa-responsive dystonia--clinical and genetic heterogeneity.
Review
New
Jankovic et al., Houston, United States. In Nat Rev Neurol, Jul 2015
Autosomal dominant GTP cyclohydrolase 1 deficiency, also known as Segawa disease, is the most common and best-characterized condition that manifests as DRD, but a similar presentation can be seen with genetic abnormalities that lead to deficiencies in tyrosine hydroxylase, sepiapterin reductase or other enzymes that are involved in the biosynthesis of dopamine.
Han Chinese patients with dopa-responsive dystonia exhibit a low frequency of exonic deletion in the GCH1 gene.
Li et al., Tianjin, China. In Genet Mol Res, 2014
We identified three novel mutations of the GTP cyclohydrolase 1 (GCH1) gene in patients with familial dopa-responsive dystonia (DRD), but were unable to identify meaningful sporadic mutations in patients with no obvious family DRD background.
The sequence diversity and expression among genes of the folic acid biosynthesis pathway in industrial Saccharomyces strains.
Misiewicz et al., Warsaw, Poland. In Acta Biochim Pol, 2014
The objective of this study was to select the optimal producing yeast strain by determining the differences in nucleotide sequences in the FOL2, FOL3 and DFR1 genes of folic acid biosynthesis pathway.
Genetics in dystonia.
Review
Klein, Lübeck, Germany. In Parkinsonism Relat Disord, 2014
While Hermann Oppenheim probably described the first cases of genetic (DYT1) dystonia in 1911, the 'modern history' of dystonia genetics dates back to 1994 when mutations in the GTP cyclohydrolase I gene were discovered to cause dopa-responsive dystonia.
The neurobiology of tetrahydrobiopterin biosynthesis: a model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neurons.
Review
Kapatos, Detroit, United States. In Iubmb Life, 2013
GTP cyclohydrolase I (GTPCH) catalyzes the first and limiting step in the BH4 biosynthetic pathway, which is now thought to involve up to eight different proteins supporting six alternate de novo and two alternate salvage pathways.
GTP cyclohydrolase regulation: implications for brain development and function.
Review
Kondo et al., Yokohama, Japan. In Adv Pharmacol, 2012
GTP cyclohydrolase (GCH) is the first and rate-limiting enzyme for BH4 biosynthesis.
Monoamine neurotransmitter deficiencies.
Review
Pearl, Washington, D.C., United States. In Handb Clin Neurol, 2012
The first, autosomal dominantly inherited GTP cyclohydrolase deficiency, has a satisfying response to therapy at any age with benefits maintained over time.
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.
Impact
Woolf et al., United States. In Nat Med, 2006
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain.
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene.
Impact
Tsuji et al., Japan. In Nat Genet, 1994
Here we report that GTP cyclohydrolase I is mapped to 14q22.1-q22.2.
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity.
Impact
Hatakeyama et al., Ōsaka, Japan. In Science, 1993
The inhibition occurred through BH4-dependent complex formation between p35 protein and GTP cyclohydrolase I. Furthermore, the inhibition was specifically reversed by phenylalanine, and, in conjunction with p35, phenylalanine reduced the cooperativity of GTP cyclohydrolase I.
Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex.
Impact
Nichol et al., In Science, 1981
Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of rats treated with insulin or reserpine.
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