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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog

GT8
This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: glycosyltransferase, ACID, YB-1, telomerase reverse transcriptase, CIs
Papers on GT8
Functional analysis of 3'UTR polymorphisms in the caprine SLC11A1 gene and its association with the Mycobacterium avium subsp. paratuberculosis infection.
New
Ikonomopoulos et al., Athens, Greece. In Vet Immunol Immunopathol, Oct 2015
The GT16 polymorphism at region A, combined with the GT8 polymorphism at region B, results in up-regulation of the SLC11A1 gene.
Significance of galactinol and raffinose family oligosaccharide synthesis in plants.
Review
Majumder et al., Calcutta, India. In Front Plant Sci, 2014
a GT8 family glycosyltransferase that galactosylates myo-inositol to produce galactinol.
Identification of three hydroxyproline O-arabinosyltransferases in Arabidopsis thaliana.
Matsubayashi et al., Okazaki, Japan. In Nat Chem Biol, 2013
Here, we purified and identified Arabidopsis HPAT as a Golgi-localized transmembrane protein that is structurally similar to the glycosyltransferase GT8 family.
LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE.
Bakker et al., Hannover, Germany. In Glycobiology, 2013
LARGE (like-glycosyltransferase) and LARGE2 (glycosyltransferase-like 1B (GYLTL1B)) are homologous Golgi glycosyltransferases possessing two catalytic domains with homology to members of glycosyltransferase families GT8 and GT49.
Arabidopsis GUX proteins are glucuronyltransferases responsible for the addition of glucuronic acid side chains onto xylan.
Ye et al., Athens, United States. In Plant Cell Physiol, 2012
It has recently been shown that mutations of two Arabidopsis family GT8 genes, GUX1 and GUX2, affect the addition of GlcA and MeGlcA to xylan, but it is not known whether they encode glucuronyltransferases (GlcATs) or indirectly regulate the GlcAT activity.
Galactinol synthase across evolutionary diverse taxa: functional preference for higher plants?
Majumder et al., Calcutta, India. In Febs Lett, 2012
Galactinol synthase (GolS), a GT8 family glycosyltransferase, synthesizes galactinol and raffinose series of oligosaccharides (RFOs).
Improved diagnostics lead to identification of three new patients with congenital disorder of glycosylation-Ip.
GeneRIF
Körner et al., Heidelberg, Germany. In Hum Mutat, 2012
After identifying the congenital disorders of glycosylation-Ip index patient, study describe three more cases suffering from an ALG11 deficiency.
The ability of land plants to synthesize glucuronoxylans predates the evolution of tracheophytes.
York et al., Athens, United States. In Glycobiology, 2012
Phylogenetic studies showed that the P. patens genome contains genes with high sequence similarity to Arabidopsis CAZy family GT8, GT43 and GT47 glycosyltransferases that are likely involved in xylan synthesis.
Molecular dissection of xylan biosynthesis during wood formation in poplar.
Ye et al., Athens, United States. In Mol Plant, 2011
In this report, we investigated roles of poplar families GT43 and GT8 glycosyltransferases in xylan biosynthesis during wood formation.
Down-regulation of glycosyltransferase 8D genes in Populus trichocarpa caused reduced mechanical strength and xylan content in wood.
Chiang et al., Raleigh, United States. In Tree Physiol, 2011
Members of glycosyltransferase protein families GT8, GT43 and GT47 are implicated in the biosynthesis of xylan in the secondary cell walls of Arabidopsis.
Evolution and function of the plant cell wall synthesis-related glycosyltransferase family 8.
Xu et al., Athens, United States. In Plant Physiol, 2010
Carbohydrate-active enzyme glycosyltransferase family 8 (GT8) includes the plant galacturonosyltransferase1-related gene family of proven and putative alpha-galacturonosyltransferase (GAUT) and GAUT-like (GATL) genes.
A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip.
GeneRIF
Körner et al., Heidelberg, Germany. In Hum Mol Genet, 2010
Deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation.
Identification, characterization, and biosynthesis of a novel N-glycan modification in the fruiting body of the basidiomycete Coprinopsis cinerea.
Aebi et al., Zürich, Switzerland. In J Biol Chem, 2010
This novel glycosyltransferase belongs to the glycosyltransferase family 8 (GT8) and is predicted to be a type II membrane protein.
Small-interfering RNAs from natural antisense transcripts derived from a cellulose synthase gene modulate cell wall biosynthesis in barley.
Carpita et al., West Lafayette, United States. In Proc Natl Acad Sci U S A, 2009
The increases in abundance of the CesA6 antisense transcript and the 21-nt and 24-nt siRNAs derived from the transcript are coincident with the down-regulation of primary wall CesAs, several Csl genes, and GT8 glycosyl transferase genes, and are correlated with the reduction in rates of cellulose and (1 --> 3),(1 --> 4)-beta-D-glucan synthesis.
The PARVUS gene is expressed in cells undergoing secondary wall thickening and is essential for glucuronoxylan biosynthesis.
Ye et al., Athens, United States. In Plant Cell Physiol, 2007
In this study, we demonstrate that PARVUS, which is a member of family GT8, is required for the biosynthesis of the tetrasaccharide primer sequence, beta-D-Xyl-(1 --> 3)-alpha-l-Rha-(1 --> 2)-alpha-D-GalA-(1 --> 4)-D-Xyl, located at the reducing end of GX.
UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man.
Bishop et al., Houston, United States. In Biol Reprod, 2006
However, a second active retroposon, UTP14c, is found within a widely expressed, putative glycosyl transferase-containing gene, GT8, on human chromosome 13.
Carbohydrate-active enzymes involved in the secondary cell wall biogenesis in hybrid aspen.
Teeri et al., Stockholm, Sweden. In Plant Physiol, 2005
Bioinformatic analyses using the sensitive tools developed for carbohydrate-active enzymes allowed the identification of 25 xylem-specific glycosyltransferases belonging to the Carbohydrate-Active EnZYme families GT2, GT8, GT14, GT31, GT43, GT47, and GT61 and nine glycosidases (or transglycosidases) belonging to the Carbohydrate-Active EnZYme families GH9, GH10, GH16, GH17, GH19, GH28, GH35, and GH51.
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