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Glutathione S-transferase theta 1

GSTT1
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GSTM1, GST, POLYMERASE, HAD, AGE
Papers on GSTT1
Impact of null genotypes of GSTT1 and GSTM1 with uterine leiomyoma risk in Iranian population.
New
Javadi et al., Tehrān, Iran. In J Obstet Gynaecol Res, Feb 2016
AIM: Few studies have investigated the role of the GSTM1 and GSTT1 genes in uterine leiomyoma.
Genetic risk factors of cisplatin induced ototoxicity in adult patients.
New
Vogazianos et al., In Neoplasma, Feb 2016
Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of: two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).
GSTT1 and GSTM1 polymorphisms predict treatment outcome for breast cancer: a systematic review and meta-analysis.
Review
New
Su et al., Nanning, China. In Tumour Biol, Dec 2015
UNASSIGNED: Observational studies have reported controversial results on the association between GSTT1 and GSTM1 genotypes and treatment outcome of breast cancer.
The effect of GSTT1, GSTM1 and GSTP1 gene polymorphisms on the susceptibility of age-related cataract in Chinese Han population.
Zhou et al., Zhengzhou, China. In Int J Clin Exp Med, 2014
The genetic polymorphisms of many glutathione S-transferases coding genes are likely to be closely related to the development of ARC, especially the GSTT1, the GSTM1 and the GSTP1.
Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis.
Review
Park et al., Seoul, South Korea. In Int J Mol Sci, 2014
Therefore, we performed a meta-analysis to explore the association between the GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of schizophrenia.
GSTT1 polymorphism and breast cancer risk in the Chinese population: an updated meta-analysis and review.
Review
Li et al., Ningbo, China. In Int J Clin Exp Med, 2014
BACKGROUND: Although a number of studies have been conducted on the association between GSTT1 polymorphism and breast cancer in China, this association remains elusive and controversial.
Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis.
Review
Jain et al., Sāgar, India. In Asian Pac J Cancer Prev, 2014
Under abnormal conditions the excessive reactive oxygen species generation results in genetic predisposition of various genes (as ADH, ALDH, CYP2E1, GSTT1, GSTP1 and GSTM1) involved in xenobiotic metabolic pathways, associated with susceptibility to different liver related diseases such as fibrosis, cirrhosis and hepatocellular carcinoma.
Genetic susceptibility in childhood acute leukaemias: a systematic review.
Review
Pombo-de-Oliveira et al., Rio de Janeiro, Brazil. In Ecancermedicalscience, 2014
We observed that the most frequently investigated genes were: NQO1, GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, CYP2D6, CYP2E1, MDR1 (ABCB1), XRCC1, ARID5B, and IKZF1.
Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis.
Zhang et al., Xinxiang, China. In Genet Mol Res, 2014
The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 control subjects.
Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás.
Moura et al., Goiânia, Brazil. In Genet Mol Res, 2014
Epidemiological studies have suggested that individuals with homozygous deletion of glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) are at higher risk of developing several types of neoplasias.
Association of GSTM1 and GSTT1 with ageing in auto repair shop workers.
GeneRIF
Devan et al., Kuala Selangor, Malaysia. In Genet Mol Res, 2011
It was concluded that early ageing is under the influence of GSTM1 and GSTT1 and the environmental and socio-demographic factors.
Indication for joint replacement and glutathione s-transferases M1 and T1 genotypes.
GeneRIF
Golka et al., Menden, Germany. In J Toxicol Environ Health A, 2011
The frequency of GSTT1 negative genotype in osteoarthritis cases and controls was normal
[Genetic background of cisplatin induced ototoxicity].
GeneRIF
Cvanová et al., Brno, Czech Republic. In Klin Onkol, 2011
early onset of cisplatin induced hearing impairment with absence of null allele of GSTT1
Evaluation of glutathione S-transferase GSTM1 and GSTT1 polymorphisms and methylmercury metabolism in an exposed Amazon population.
GeneRIF
Barbosa et al., Ribeirão Preto, Brazil. In J Toxicol Environ Health A, 2011
These data suggest that GST polymorphisms may be associated with methylmercury detoxification.
[Polymorphism of GSTT1 and GSNM1 glutathione transferase genes in smokers and patients at the early stages of chronic obstructive pulmonary disease].
GeneRIF
Isaeva et al., In Klin Med (mosk), 2011
Deletion polymorphism of GSTT1 glutathione transferase gene is recommended as a marker for predictive diagnostics of development and progress of chronic obstructive pulmonary disease.
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Impact
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05.
Impact
Laurent-Puig et al., Villejuif, France. In J Clin Oncol, 2010
Twenty polymorphisms within the DPD, TS, MTHFR, ERCC1, ERCC2, GSTP1, GSTM1, GSTT1, and UGT1A1 genes were genotyped.
Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie.
Impact
Stoehlmacher et al., Dresden, Germany. In J Clin Oncol, 2009
Polymorphisms within genes of TS, MTHFR, MTR, OPRT, XPD, ERCC1, XRCC1, XPA, GSTP1, GSTT1, and GSTM1 were genotyped using polymerase chain reaction-based techniques.
Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors.
Impact
Fossa et al., Oslo, Norway. In J Clin Oncol, 2007
Known functional polymorphisms (positive or negative) in GSTT1 and GSTM1 and codon 105 A/G (Ile/Val) in GSTP1 were analyzed by multiplex polymerase chain reaction, followed by restriction enzyme cutting, and separated by gel electrophoresis.
Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach.
Impact
Canzian et al., Lyon, France. In Lancet, 2005
We therefore studied the role of cruciferous vegetables in lung cancer after stratifying by GSTM1 and GSTT1 status, two genes implicated in the elimination of isothiocyanates, the likely chemopreventative compound.
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