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Glutathione S-transferase omega 2

GSTO2, glutathione S-transferase omega 2
The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] (from NCBI)
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Top mentioned proteins: GST, AGE, GSTM1, GSTT1, HAD
Papers on GSTO2
Impacts on silkworm larvae midgut proteomics by transgenic Trichoderma strain and analysis of glutathione S-transferase sigma 2 gene essential for anti-stress response of silkworm larvae.
New
Chen et al., Shanghai, China. In J Proteomics, Sep 2015
Expression of glutathione S-transferase omega 2 (GSTo2) was also enhanced when larvae were fed with mulberry leaves treated with the transgenic Trichoderma strain.
Glutathione S-transferase O2 gene rs157077 polymorphism predicts response to transarterial chemoembolization in hepatocellular carcinoma.
New
Liu et al., Xi'an, China. In Tumour Biol, Aug 2015
Some genetic alterations of glutathione S-transferase omega 2 (GSTO2) have been reported to increase the risk of many malignancies, including hepatocellular carcinoma (HCC); however, their prognostic capability remained unresolved in HCC patients treated with transarterial chemoembolization (TACE).
Childhood Pre-B acute lymphoblastic leukemia and glutathione S-transferase omega 1 and 2 polymorphisms.
New
Mansouri et al., Tehrān, Iran. In Int J Lab Hematol, Aug 2015
GSTO1 and GSTO2 polymorphisms have been reported to be related to several types of disease.
Biological monitoring and the influence of genetic polymorphism of As3MT and GSTs on distribution of urinary arsenic species in occupational exposure workers.
New
Wasowicz et al., Łódź, Poland. In Int Arch Occup Environ Health, Aug 2015
To elucidate the role of genetic factors in arsenic (As) metabolism, we studied the associations of six polymorphisms: As3MT Met287Thr (T>C) in exon 9; As3MT A>G in 5'UTR; As3MT C>G in intron 6; As3MT T>G in intron 1; GSTP1 Ile105Val and GSTO2 T>C.
Association of GSTO2 (N142D), GSTT1, and GSTM1 Polymorphisms With Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients.
New
Ramzi et al., Shīrāz, Iran. In Exp Clin Transplant, Jul 2015
GSTM1, GSTT1, and GSTO2 are important genes that interfere with xenobiotic and drug metabolism.
Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients.
New
Liu et al., Xi'an, China. In World J Gastroenterol, May 2015
METHODS: Twelve tagging SNPs in GST genes (including GSTA1, GSTA4, GSTM2, GSTM3, GSTO1, GSTO2 and GSTP1) were genotyped using Sequenom MassARRAY iPLEX genotyping method in a cohort of 214 Chinese patients with resected HCC.
GSTO1*C/GSTO2*G haplotype is associated with risk of transitional cell carcinoma of urinary bladder.
New
Savic-Radojevic et al., Belgrade, Serbia. In Int Urol Nephrol, Apr 2015
PURPOSE: To clarify the role of genetic polymorphisms of GSTO1 (rs4925) and GSTO2 (rs156697) in individual susceptibility to urinary bladder cancer.
Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects.
Nord et al., Stockholm, Sweden. In Pharmacol Res Perspect, 2014
The majority of the differentially expressed genes were higher expressed in the central airways such as the transporters SLC2A1 (GLUT1), SLC28A3 (CNT3), and SLC22A4 (OCTN1) and the drug-metabolizing enzymes GSTZ1, GSTO2, and CYP2F1.
Functional variability of glutathione S-transferases in Basque populations.
Fuciarelli et al., Roma, Italy. In Am J Hum Biol, 2014
We have focused our attention on the polymorphic variants of the GSTA1, GSTM1, GSTO1, GSTO2, GSTP1, GSTT1, and GSTT2B genes.
GSTA1*-69C/T and GSTO2*N142D as asthma- and allergy-related risk factors in Italian adult patients.
Fuciarelli et al., Roma, Italy. In Clin Exp Pharmacol Physiol, 2014
Specifically, our previous study on asthmatic children highlighted GSTA1 and GSTO2 as novel susceptibility loci for asthma.
Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies.
Xu et al., Nanjing, China. In Sci Rep, 2013
Overall, the pooled results revealed a significantly increased risk of susceptibility for GSTO2 polymorphism (GG vs. AA: OR = 1.20, 95%CI: 1.02-1.41,
Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients.
Simic et al., Belgrade, Serbia. In Plos One, 2012
OBJECTIVE: To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy.
Glutathione S-transferase Omega 2 Genetic Polymorphism and Risk of Hepatic Failure that Lead to Liver Transplantation in Iranian Population.
Saadat et al., Shīrāz, Iran. In Int J Organ Transplant Med, 2012
GSTO2 (N142D) is a member of this family the polymorphism of which may influence the metabolism of active components and free radicals and may contribute to hepatic failure.
Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases.
GeneRIF
Oakley et al., Canberra, Australia. In J Mol Biol, 2012
crystal structures of human GSTO2-2, stabilized through site-directed mutagenesis and determined at 1.9 A resolution in the presence and absence of glutathione
Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children.
GeneRIF
Fuciarelli et al., Roma, Italy. In Clin Chem Lab Med, 2012
GSTA1 and the GSTO2 are asthma susceptible genes involved in increasing the risk of asthma development in the Italian population
Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications.
GeneRIF
Ertekin-Taner et al., Jacksonville, United States. In Mol Neurodegener, 2011
Found that rs156697 minor allele of GSTO2 associates with increased risk in the older ADs with age-at-diagnosis > 80 years. The minor alleles of GSTO1 rs4925 and GSTO2 rs156697 associate with lower brain levels of GSTO2, but not GSTO1.
Association between N142D genetic polymorphism of GSTO2 and susceptibility to colorectal cancer.
GeneRIF
Saadat et al., Shīrāz, Iran. In Mol Biol Rep, 2011
GSTO2 NN genotype increase the risk of colorectal cancer in persons with positive family history for cancer in the first degree relatives.
[Relationships between the gene polymorphisms of drug metabolizing enzymes and the outcome of the first induction chemotherapy in patients with de novo acute myeloid leukemia].
GeneRIF
Han et al., Tianjin, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011
CYP2D6 (rs16947) and GSTO2 (rs156697) polymorphisms are independent factors influencing complete remission rates of the first induction chemotherapy in de novo AML patients.
Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis.
Review
El-Serag et al., Houston, United States. In Am J Epidemiol, 2008
Fifteen eligible studies were identified: 14 evaluated GSTM1; 13, GSTT1; three, GSTP1; and one each evaluated GSTM2, GSTM3, GSTA1, GSTA4, GSTO1, and GSTO2, respectively.
Characterization of the omega class of glutathione transferases.
Review
Board et al., Brisbane, Australia. In Methods Enzymol, 2004
GSTO2 is expressed predominantly in the testis, although moderate levels of expression are seen in other tissues.
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