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Glutathione S-transferase mu 1

GSTM1, glutathione S-transferase M1
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GSTT1, GST, HAD, POLYMERASE, AGE
Papers on GSTM1
Candidate genes involved in the susceptibility of primary open angle glaucoma.
Review
New
Kaur et al., New Delhi, India. In Gene, Mar 2016
Also, the role of Cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), Glutathione S-transferase mu 1 (GSTM1) and Neurotrophin (NTF4) has been fairly identified.
Impact of null genotypes of GSTT1 and GSTM1 with uterine leiomyoma risk in Iranian population.
New
Javadi et al., Tehrān, Iran. In J Obstet Gynaecol Res, Feb 2016
AIM: Few studies have investigated the role of the GSTM1 and GSTT1 genes in uterine leiomyoma.
Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility.
New
Liu et al., Jingmen, China. In Genet Mol Res, Dec 2015
Currently, most research has investigated the GSTM1, XRCC1, XRCC3, CYP2D6, and C188T genes.
GSTT1 and GSTM1 polymorphisms predict treatment outcome for breast cancer: a systematic review and meta-analysis.
Review
New
Su et al., Nanning, China. In Tumour Biol, Dec 2015
UNASSIGNED: Observational studies have reported controversial results on the association between GSTT1 and GSTM1 genotypes and treatment outcome of breast cancer.
Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis.
Zhang et al., Xinxiang, China. In Genet Mol Res, 2014
The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 control subjects.
Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás.
Moura et al., Goiânia, Brazil. In Genet Mol Res, 2014
Epidemiological studies have suggested that individuals with homozygous deletion of glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) are at higher risk of developing several types of neoplasias.
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Review
Amoli et al., Tehrān, Iran. In J Diabetes Res, 2014
We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications.
Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis.
Review
Park et al., Seoul, South Korea. In Int J Mol Sci, 2014
Therefore, we performed a meta-analysis to explore the association between the GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of schizophrenia.
Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors.
Review
Filip et al., Lublin, Poland. In Biomed Res Int, 2014
Polymorphisms in GSTM1, GSTP1, and GSTO1 enzymes increase the risk of developing breast cancer and hepatocellular carcinoma.
Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang.
Yisikandaer et al., Ürümqi, China. In Genet Mol Res, 2014
This study aimed to investigate the correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer (EC) among the Kazakh ethnic group in Xinjiang.
GST polymorphisms and early-onset coronary artery disease in young South African Indians.
GeneRIF
Chuturgoon et al., Durban, South Africa. In S Afr Med J, 2012
Our findings support the association of genotypes GSTM1 0/0 and GSTP1 A105/A105 and smoking with CAD.
Indication for joint replacement and glutathione s-transferases M1 and T1 genotypes.
GeneRIF
Golka et al., Menden, Germany. In J Toxicol Environ Health A, 2011
The normal distribution of the GSTM1 negative genotype in patients with indication for hip or knee replacement indicates that the role GSTM1 in these patients is different from that in other aseptic inflammatory diseases
Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence.
GeneRIF
Souza et al., Barra do Garças, Brazil. In Genet Mol Res, 2011
There were no significant differences in CYP1A1-MspI SNP and GSTM1 genotype frequencies in this family when compared to data for Brazilian populations.
Evaluation of glutathione S-transferase GSTM1 and GSTT1 polymorphisms and methylmercury metabolism in an exposed Amazon population.
GeneRIF
Barbosa et al., Ribeirão Preto, Brazil. In J Toxicol Environ Health A, 2011
These data suggest that GST polymorphisms may be associated with methylmercury detoxification.
[Polymorphism of GSTT1 and GSNM1 glutathione transferase genes in smokers and patients at the early stages of chronic obstructive pulmonary disease].
GeneRIF
Isaeva et al., In Klin Med (mosk), 2011
The difference between the frequency of homozygous deletion of GSTM1 in smokers is insignificant in the early stages of chronic obstructive pulmonary disease.
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
Impact
Chanock et al., Bethesda, United States. In Nat Genet, 2010
validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions.
Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.
Impact
Goldberg et al., Chapel Hill, United States. In J Clin Oncol, 2010
Deletion in GSTM1 was associated with grade 4 neutropenia after FOLFOX (28% v 16%; P = .02).
Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05.
Impact
Laurent-Puig et al., Villejuif, France. In J Clin Oncol, 2010
Twenty polymorphisms within the DPD, TS, MTHFR, ERCC1, ERCC2, GSTP1, GSTM1, GSTT1, and UGT1A1 genes were genotyped.
Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie.
Impact
Stoehlmacher et al., Dresden, Germany. In J Clin Oncol, 2009
Polymorphisms within genes of TS, MTHFR, MTR, OPRT, XPD, ERCC1, XRCC1, XPA, GSTP1, GSTT1, and GSTM1 were genotyped using polymerase chain reaction-based techniques.
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
Review
Impact
Peters et al., Seattle, United States. In Jama, 2008
Assuming a very low prior probability of 0.000001, similar to a probability assumed for a randomly selected single-nucleotide polymorphism in a genome-wide association study, and statistical power to detect an OR of 1.5, 4 associations were considered noteworthy as denoted by an FPRP value <0.2: GSTM1 null and bladder cancer (OR, 1.5; 95% CI, 1.3-1.6;
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