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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutathione S-transferase, alpha 4

GSTA4, mGSTA4-4, GSTA4-4, hGSTA4-4, mGSTA4
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GST, Leukocyte Elastase, CAN, ACID, HAD
Papers on GSTA4
Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.
New
Petersen et al., Aurora, United States. In Redox Biol, Apr 2016
These data define a role for GSTA4-4 in buffering hepatic oxidative stress associated with chronic alcohol consumption and that this GST isoform plays an important role in protecting against carbonylation of mitochondrial proteins.
Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.
Review
New
Awasthi et al., Duarte, United States. In Toxicol Appl Pharmacol, Jan 2016
Cells exposed to mild, transient heat or oxidative stress acquire the capacity to exclude intracellular 4HNE at a faster rate by inducing GSTA4-4 which conjugates 4HNE to glutathione (GSH), and RLIP76 which mediates the ATP-dependent transport of the GSH-conjugate of 4HNE (GS-HNE).
The presence of carbon nanostructures in bakery products induces metabolic stress in human mesenchymal stem cells through CYP1A and p53 gene expression.
New
Alshatwi et al., Riyadh, Saudi Arabia. In Environ Toxicol Pharmacol, Jan 2016
The levels of the mRNA transcripts of metabolic stress-responsive genes such as CAT, GSR, GSTA4, CYP1A and p53 were significantly altered in response to CNs.
Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis.
New
Petersen et al., Aurora, United States. In Free Radic Biol Med, Dec 2015
Western analysis revealed increased expression of GSTA4 and GSTπ in human ALD.
The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells.
New
Tremblay et al., Québec, Canada. In Endocrinology, Dec 2015
Similar results were obtained on the Gsta2, Gsta3, and Gsta4 promoters, suggesting a global role for MEF2 factors in the regulation of all 4 Gsta genes.
Age-specific Regulation of Drug-processing Genes in Mouse Liver by Ligands of Xenobiotic-sensing Transcription Factors.
New
Cui et al., Seattle, United States. In Drug Metab Dispos, Dec 2015
The inducibility of DPGs was age-specific: 1) during neonatal age, the highest fold-increase in the mRNA expression was observed for Cyp1a2, Sult5a1 and Ugt1a9 by TCDD; Cyp3a11 and Mrp2 by TCPOBOP; as well as Gstm2 and Gstm3 by PCN; 2) during adolescent age, the highest fold-increase in the mRNA expression was observed for Ugt1a6 and Mrp4 by TCDD; Cyp2b10, Ugt2b34, and Ugt2b35 by TCPOBOP; as well as Gsta1, Gsta4, Sult1e1, Ugt1a1, Mrp3, and Mrp4 by PCN; 3) in adults, the highest fold-increase in the mRNA expression was observed for Aldh1a1, Aldh1a7, and Ugt2b36 by TCPOBOP; as well as Papss2 and Oatp1a4 by PCN.
Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury.
New
Bhatnagar et al., Louisville, United States. In Circ Res, Sep 2015
METHODS AND RESULTS: In adult male C57BL/6 mouse hearts, Gstp1/2 was the most abundant GST transcript followed by Gsta4 and Gstm4.1, and GSTP activity was a significant fraction of the total GST activity.
Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model.
New
Singh et al., Little Rock, United States. In Radiat Res, Jun 2015
Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress.
Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients.
New
Liu et al., Xi'an, China. In World J Gastroenterol, May 2015
METHODS: Twelve tagging SNPs in GST genes (including GSTA1, GSTA4, GSTM2, GSTM3, GSTO1, GSTO2 and GSTP1) were genotyped using Sequenom MassARRAY iPLEX genotyping method in a cohort of 214 Chinese patients with resected HCC.
Effects of silver nanoparticles on neonatal testis development in mice.
Kim et al., Seoul, South Korea. In Int J Nanomedicine, 2014
The results of reverse transcription-quantitative polymerase chain reaction indicated that the E1f1ay, Gsta4, and Fdx1 genes were up-regulated, and the Amh, Cx43, and Claudin-11 genes were down-regulated in response to AgNPs exposure on PND28; however, these genes recovered at PND60.
Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.
GeneRIF
Rahme et al., Boston, United States. In Faseb J, 2012
GSTA4 down-regulation and the concomitant increase in 4-hydroxynonenal adducts in muscle are indicative of susceptibility to infection in individuals with severe thermal injuries.
Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease.
Review
Raza, Ukraine. In Febs J, 2011
This review highlights the significance of the mitochondrial GST pool, particularly the mechanism and significance of dual targeting of GSTA4-4 under in vitro and in vivo conditions.
The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.
GeneRIF
Shimosegawa et al., Sendai, Japan. In Mol Carcinog, 2011
Data show that mandatory overexpression of hGSTA4 by transient transfection in KYSE30 cells and attenuation of HNE-induced EGFR phosphorylation.
2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis.
GeneRIF
Zhao et al., Shanghai, China. In Am J Otolaryngol, 2011
2-APB treatment restrained nasal lavage fluid LTC4, ECP, ovalbumin-specific IgE, and IL-4 and their corresponding mRNAs in the previously mentioned tissues of treated mice in comparison with those of control ones.
Interactions of glutathione transferases with 4-hydroxynonenal.
Review
Atkins et al., United States. In Drug Metab Rev, 2011
Some of the key determining characteristics that impart high alkenal activity reside in the unique C-terminal interactions of the GSTA4-4 enzyme.
Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.
GeneRIF
DiGiovanni et al., United States. In J Natl Cancer Inst, 2010
Gsta4/GSTA4 is a novel susceptibility gene for NMSC that affects risk in both mice and humans.
Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals.
GeneRIF
Nordestgaard et al., Copenhagen, Denmark. In J Thromb Haemost, 2010
analysis of four novel mutations that change the function of leukotriene C(4) synthase and are associated with increased risk of venous thromboembolism and ischemic stroke
Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre.
Review
Glei et al., Jena, Germany. In Mutat Res, 2009
In HT29 tumour cells, e.g., mRNA GSTA4, GSTP1, GSTM2, and GSTT2 were induced.
Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis.
Review
El-Serag et al., Houston, United States. In Am J Epidemiol, 2008
Fifteen eligible studies were identified: 14 evaluated GSTM1; 13, GSTT1; three, GSTP1; and one each evaluated GSTM2, GSTM3, GSTA1, GSTA4, GSTO1, and GSTO2, respectively.
Glutathione transferases.
Review
Impact
Jowsey et al., Dundee, United Kingdom. In Annu Rev Pharmacol Toxicol, 2004
Furthermore, knockout of mouse GSTA4 and GSTZ1 leads to overexpression of transferases in the Alpha, Mu, and Pi classes, an observation suggesting they are part of an adaptive mechanism that responds to endogenous chemical cues such as 4-hydroxynonenal and tyrosine degradation products.
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