Age-specific Regulation of Drug-processing Genes in Mouse Liver by Ligands of Xenobiotic-sensing Transcription Factors.
Seattle, United States. In Drug Metab Dispos, 17 Dec 2015
The inducibility of DPGs was age-specific: 1) during neonatal age, the highest fold-increase in the mRNA expression was observed for Cyp1a2, Sult5a1 and Ugt1a9 by TCDD; Cyp3a11 and Mrp2 by TCPOBOP; as well as Gstm2 and Gstm3 by PCN; 2) during adolescent age, the highest fold-increase in the mRNA expression was observed for Ugt1a6 and Mrp4 by TCDD; Cyp2b10, Ugt2b34, and Ugt2b35 by TCPOBOP; as well as Gsta1, Gsta4, Sult1e1, Ugt1a1, Mrp3, and Mrp4 by PCN; 3) in adults, the highest fold-increase in the mRNA expression was observed for Aldh1a1, Aldh1a7, and Ugt2b36 by TCPOBOP; as well as Papss2 and Oatp1a4 by PCN.
Reactive aldehyde-scavenging enzyme activities in atherosclerotic plaques of cigarette smokers and nonsmokers.
Chieti, Italy. In Atherosclerosis, Feb 2015
METHODS: We have assessed specific enzymatic activities of class 1, 2, and 3 aldehyde dehydrogenase (ALDH1, ALDH2, and ALDH3, respectively), glutathione S-transferase (isozyme A4-4, GSTA4-4), and aldose reductase (AR), namely the major reactive aldehyde-scavenging enzymes, together with lipid peroxidation, i.e., fluorescent damage products of lipid peroxidation (FDPL), in carotid atherosclerotic plaques surgically removed from 17 cigarette smokers and 17 nonsmokers.
Effects of silver nanoparticles on neonatal testis development in mice.
Seoul, South Korea. In Int J Nanomedicine, 2014
The results of reverse transcription-quantitative polymerase chain reaction indicated that the E1f1ay, Gsta4, and Fdx1 genes were up-regulated, and the Amh, Cx43, and Claudin-11 genes were down-regulated in response to AgNPs exposure on PND28; however, these genes recovered at PND60.
Dundee, United Kingdom. In Annu Rev Pharmacol Toxicol, 2004
Furthermore, knockout of mouse GSTA4 and GSTZ1 leads to overexpression of transferases in the Alpha, Mu, and Pi classes, an observation suggesting they are part of an adaptive mechanism that responds to endogenous chemical cues such as 4-hydroxynonenal and tyrosine degradation products.