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Glutathione S-transferase kappa 1

GST
This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, catalase, SOD, V1a
Papers using GST antibodies
Mitochondria supply membranes for autophagosome biogenesis during starvation.
Supplier
Meurs Eliane F., In PLoS ONE, 2009
... clone HA-7 ascites fluid (Sigma) against the HA tag, clone GST-2 ascites fluid (Sigma) against GST, anti-GFP (Roche Diagnostics), QIAexpress Anti-His antibodies (Qiagen) against the His tag ...
Of the vulnerability of orphan complex proteins: The case study of the E. coli IscU and IscS proteins.
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Doering Christopher B., In PLoS ONE, 2009
... In short, they were produced as fusion proteins with a His-tagged GST and purified by affinity chromatography using Ni-NTA agarose gel (QIAGEN).
A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes
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Pal Soumitro, In PLoS ONE, 2008
... Louis, Missouri), anti-GST conjugated to HRP (Santa Cruz Biotechnology, Santa Cruz, CA), anti-Ras ...
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
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Lenting Peter J., In PLoS ONE, 2008
... The anti-phospho-ERK1/2 (pY204) and anti-GST antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling.
Supplier
Thi Thu Nguyen Hang, In PLoS ONE, 2008
... Antibodies to p65, phospho-NF-κB p65 (Ser 276), IκBα, and GST were purchased from Cell Signaling (Danvers, MA, USA) ...
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Papers on GST
Identification of KSHV vIRF1 as a novel interaction partner of human deubiquitinase USP7.
New
Saridakis et al., Canada. In J Biol Chem, Feb 2016
GST pull-down assays demonstrated that vIRF1 interacts with USP7-NTD via its EGPS motif.
Cross-talk between EPAS-1/HIF-2α and PXR Signaling Pathway Regulates Multi-drug Resistance of Stomach Cancer Cell.
New
Xu et al., Beijing, China. In Int J Biochem Cell Biol, Feb 2016
Protein-protein interaction between EPAS-1 and PXR was identified by co-immunoprecipitation and GST-pull down assays.
Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.
Review
New
Awasthi et al., Duarte, United States. In Toxicol Appl Pharmacol, Jan 2016
In this article, we provide a brief summary of the cellular effects of 4HNE, followed by a review of its GST-catalyzed detoxification, with an emphasis on the structural attributes that play an important role in the interactions with alpha-class GSTA4-4.
Pharmacogenetics of isoniazid-induced hepatotoxicity.
Review
New
Wilffert et al., Yogyakarta, Indonesia. In Drug Metab Rev, May 2015
We selected English articles of studies in human from PubMed up to May 2014 with the keywords pharmacogenetic, isoniazid and hepatotoxicity, N-acetyl transferase 2 (NAT2), CYP2E1 and glutathione S transferase (GST).
Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy.
Review
New
Toffoli et al., Italy. In Drug Resist Updat, May 2015
Heritable genetic variants in the ABC and SLC transport pathways; in the CYP450, GST, and UGT-mediated phase I and II metabolism; in the folate metabolic pathway; as well as in the EGF and VEGF signaling pathways, have been associated with a distinct tumor sensitivity phenotype in CRC patients treated with fluoropyrimidines combined with either irinotecan, oxaliplatin or targeted biological agents.
Genes of the de novo and Salvage Biosynthesis Pathways of Vitamin B6 are Regulated under Oxidative Stress in the Plant Pathogen Rhizoctonia solani.
Jabaji et al., Canada. In Front Microbiol, 2014
We also examined their regulation when subjected to reactive oxygen species (ROS) stress inducers, the superoxide generator paraquat, or H2O2, and compared it to the well-known antioxidant genes, catalase and glutathione-S-transferase (GST).
Applying a Weight-of-Evidence Approach to Evaluate Relevance of Molecular Landscapes in the Exposure-Disease Paradigm.
Review
Fedak et al., Boulder, United States. In Biomed Res Int, 2014
Using this weight-of-evidence method, we found overlapping polymorphisms in the genes for the metabolic enzymes GST and NQO1, both of which may infer risk of benzene-induced MDS.
Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis.
Review
Park et al., Seoul, South Korea. In Int J Mol Sci, 2014
The association between polymorphisms of glutathione-related enzyme (GST) genes and the risk of schizophrenia has been investigated in many published studies.
Genetic diversity of the Neotropical tree Hancornia speciosa Gomes in natural populations in Northeastern Brazil.
Moraes Filho et al., Recife, Brazil. In Genet Mol Res, 2014
The results showed a high level of genetic diversity (0.30), and found that only around 30% of genetic variability is distributed among populations (GST = 0.29, ФST = 0.30), with the remainder (ФCT = 70%) found within each population, as expected for forest outcrossing species.
Identification of Surface Proteins from Lactobacillus casei BL23 Able to Bind Fibronectin and Collagen.
Monedero et al., Paterna, Spain. In Probiotics Antimicrob Proteins, 2011
The latter two enzymes were expressed in Escherichia coli and purified as glutathione-S-transferase (GST) fusion proteins, and their in vitro binding activity to fibronectin and collagen was confirmed.
GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population.
GeneRIF
Fukuoka Kinki Parkinson's Disease Study Group et al., Fukuoka, Japan. In Parkinsonism Relat Disord, 2010
This study does not give evidence of interaction between the GST polymorphisms and smoking may although this study provided sufficient statistical power to detect modest interaction.
Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors.
GeneRIF
Karpf et al., Buffalo, United States. In Prostate, 2009
Gst genes are extensively downregulated in primary but not metastatic TRAMP tumors.
Group B Streptococcus induces tyrosine phosphorylation of annexin V and glutathione S-transferase in human umbilical vein endothelial cells.
GeneRIF
Nagao et al., Rio de Janeiro, Brazil. In Int J Mol Med, 2009
The objective of this study was to investigate the molecular mechanisms underlying Group B Streptococcus-human umbilical vein endothelial cells interaction, focusing specifically on the responsiveness of host protein tyrosine kinase (PTK).
Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility.
GeneRIF
Aydos et al., Ankara, Turkey. In Fertil Steril, 2009
Our results suggest that genetic polymorphisms of xenobiotic-metabolizing enzymes could play an important role in infertility.
Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome.
Impact
Picci et al., Bologna, Italy. In J Clin Oncol, 2009
The expression of MGST1, the microsomal glutathione S-transferase (GST), was found to clearly predict EWS prognosis.
Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population.
GeneRIF
Xiang et al., Shanghai, China. In Endocr J, 2008
SNP-1308G/T (rs1917760) genotypes of DsbA-L gene might participate in insulin secretion and body fat distribution. It is possible that polymorphisms of DsbA-L gene associated with metabolic diseases[DsbA-L]
The cargo-binding domain regulates structure and activity of myosin 5.
Impact
Knight et al., Leeds, United Kingdom. In Nature, 2006
Myosin 5 heavy meromyosin, a constitutively active fragment lacking the GTDs, is inhibited and folded by a dimeric GST-GTD fusion protein.
Role of diet in prostate cancer development and progression.
Review
Impact
Giovannucci et al., San Francisco, United States. In J Clin Oncol, 2005
Several genes, such as MnSOD, XRCC1, and GST, may modify the association of specific nutrients and foods with prostate cancer risk; and further research is warranted to confirm these initial observed relationships.
GIBBERELLIN INSENSITIVE DWARF1 encodes a soluble receptor for gibberellin.
Impact
Matsuoka et al., Nagoya, Japan. In Nature, 2005
Recombinant glutathione S-transferase (GST)-GID1 had a high affinity only for biologically active GAs, whereas mutated GST-GID1 corresponding to three gid1 alleles had no GA-binding affinity.
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
Impact
Rothman et al., Bethesda, United States. In Lancet, 2005
Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent.
More papers using GST antibodies
Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5
Supplier
Ferguson Stephen SG et al., In Molecular Brain, 2007
... Anti-GST mouse monoclonal antibody and anti-Gαq/11 rabbit polyclonal antibody were from Santa Cruz Biotechnology Inc ...
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
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Kaether Christoph et al., In Cellular and Molecular Life Sciences, 2007
... β1 (3E9; Dianova), mouse anti-myc (9E10; Santa Cruz Biotechnology), rabbit anti-beta Actin (ab8227; Abcam), goat anti-GST (GE Healthcare) and normal goat IgG (Santa Cruz Biotechnology).
Reverse transcriptase- and RNA packaging signal-dependent incorporation of APOBEC3G into hepatitis B virus nucleocapsids.
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Ryu Wang-Shick, In PLoS ONE, 2007
(Covance), mouse anti-GST (Thermo Scientific), mouse anti-NPM (ARP), polyclonal ...
The ING1b tumor suppressor facilitates nucleotide excision repair by promoting chromatin accessibility to XPA
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Tong T et al., In Cell Death & Disease, 2006
... Anti-PARP was obtained from Cell Signaling Technology (Danvers, MA, USA) and anti-GST was obtained from Abgent (San Diego, CA, USA) ...
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis
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Itoh Toshiki et al., In The Journal of Cell Biology, 2006
... Rabbit anti-Tapp1 and anti-GST polyclonal antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Functional copper transport explains neurologic sparing in occipital horn syndrome
Supplier
van de Sluis Bart et al., In Cellular and Molecular Life Sciences, 2005
... Louis, MO, USA), polyclonal rabbit-anti-GST (Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1.
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Maas Stefan, In PLoS ONE, 2005
... To stabilize and enhance reporter protein expression, artificial sequence of modified glutathione S-transferase (GST) gene (QIAGEN) was introduced in front ...
Receptor activation alters inner surface potential during phagocytosis
Supplier
Grinstein Sergio et al., In The Journal of Cell Biology, 2005
... Anti-GST antibody was obtained from GE Healthcare, and goat anti–mouse HRP-conjugated antibodies were purchased from Cedarlane Labs ...
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
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Itoh Hiroshi et al., In The EMBO Journal, 2004
... We purchased anti-FLAG (M2) and anti-tubulin from Sigma; anti-cMyc (9E10), anti-FOXO1 (H128), anti-PGC-1 (H300), and anti-GST (Z-5) from Santa Cruz Biotechnology; and anti-phospho-FOXO1 (pT24), and ...
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
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Ktistakis Nicholas T. et al., In The Journal of Cell Biology, 2004
... The antibodies used in the course of this work were: mouse anti-GST (GeneTex, Inc.), mouse anti–β-COP (a ...
The ankyrin repeat as molecular architecture for protein recognition.
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Schliwa Manfred, In PLoS Biology, 2003
... Vectors for GST-CD fragments were constructed by PCR cloning using a human whole brain cDNA library (Clontech) as the template ...
Induction of neurites by the regulatory domain of PKCδ and ε in neural cells is counteracted by PKC catalytic activity and the RhoA pathway.
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Kahle Philipp J., In PLoS ONE, 2003
... from Cell Signaling, phospho-eIF2α (pSer52) antibody from Stressgen and Cell Signaling, GFP antibody from Zymed, GST antibody from Oncogene, and Dcp1a antibody from ABNOVA.
Argonaute2 is the catalytic engine of mammalian RNAi
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Young John, In PLoS Pathogens, 2003
... (BD Biosciences, San Diego, California, United States), α-p24 Gag (Advance Biotechnologies, Columbia, Maryland, United States), α-GST (Santa Cruz Biotechnology, Santa Cruz, California, United ...
A renaissance for SRC
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McNiven Mark A. et al., In The Journal of Cell Biology, 2003
... Anti-Src antibody (sc-18) and anti-GST (sc-138) were purchased from Santa Cruz Biotechnology, Inc ...
A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates
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Shapiro Paul et al., In Journal of Cell Communication and Signaling, 2002
... Following the kinase reaction GST-LIN-1 was re-isolated with Glutathione Sepharose 4B and incubated in the absence or presence of 2.5 μg λ-phosphatase (New England Biolabs) in λ-phosphatase reaction buffer ...
Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin β receptor reveals a novel mechanism of apoptosis
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Duckett Colin S. et al., In Biochemical Journal, 2002
... the following sources: anti-TRAF2 (BD Pharmingen), anti-(COX IV) (cytochrome oxidase subunit IV) (Invitrogen), anti-Smac/DIABLO (Calbiochem), anti-GST (glutathione transferase) (Santa Cruz Biotechnology), horseradish-peroxidase-conjugated anti-HA (haemagglutinin), horseradish-peroxidase-conjugated ...
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.
Supplier
Lichterfeld Mathias, In PLoS ONE, 2002
Fusion proteins c-Jun (residues 1–79)-GST and GSK-3α-GST were purchased from Upstate Biotechnology and BioVision (Mountain View, CA) ...
Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
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Ramchandran Ramani, In PLoS ONE, 2001
... Antibodies against ubiquitin, glutathione S-transferase (GST), and protein A/G plus agarose were obtained from Santa Cruz Biotechnology Inc ...
Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2.
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Buday Laszlo, In PLoS ONE, 2000
... Antibodies against ERK1/2, p-ERK 1/2 (Thr-202/Tyr-204), PAK1, GST and HA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Lysosmal Storage Diseases
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Taniike Masako et al., In Journal of Neuroinflammation, 2000
... basic protein (MBP) antibody (1:200; Sternberger Monoclonals Incorporated, Lutherville, MA), rabbit polyclonal anti-rat-pi-form of glutathione-S-transferase (pi-GST) antibody (1:1000; MBL, Nagoya, Japan), rabbit polyclonal ...
Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10
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Mostafavi-Pour Z et al., In Iranian Red Crescent Medical Journal, 1999
... Mouse monoclonal ESAT-6 antibody and Glutathione S Transferase (GST) antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
An in vitro nuclear disassembly system reveals a role for the RanGTPase system and microtubule-dependent steps in nuclear envelope breakdown
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Kutay Ulrike et al., In The Journal of Cell Biology, 1998
... mPlum-GST-M9 was generated by replacing the coding sequence of EGFP in pEGFP-C1 (CLONTECH Laboratories, Inc.) by the ...
Characterization of antihuman IFNAR-1 monoclonal antibodies: epitope localization and functional analysis.
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Diamond Michael S., In PLoS Pathogens, 1998
... Recombinant GST-p38α was purchased (Cell Signaling).
Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells
Supplier
Walzel H et al., In Cell Death & Disease, 1997
... polynucleotide kinase were purchased from Roche Molecular Biochemicals (Mannheim, Germany) and JNK1 polyclonal antibody (pAb), c-Jun(1-169)-GST were from Biomol (Hamburg, Germany) ...
Exomer: a coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast
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Schekman Randy et al., In The Journal of Cell Biology, 1997
... Anti-GST antibody was purchased from Santa Cruz Biotechnology, Inc ...
Analyzing chemotaxis using the Dunn direct-viewing chamber
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Ridley Anne J. et al., In The Journal of Cell Biology, 1996
... RhoA (clone 26C4, sc-179), RhoB (119, sc-180) and RhoC (C-16, sc-12116), GFP (FL, sc-8334), and GST (B14, sc-138; all from Santa Cruz Biotechnology, Inc.) ...
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.
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Tsuji Yoshiaki, In PLoS ONE, 1996
... Rabbit polyclonal anti-FOXO3 (sc-11351 X), rabbit polyclonal anti GR (sc-1004), rabbit polyclonal anti glutathione-S-transferase (GST) (sc-459) and normal rabbit IgG (sc-2027) were from Santa Cruz Biotechnology.
Structural and functional analyses of DNA bending induced by Sp1 family transcription factors
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Johansen Terje et al., In Cellular and Molecular Life Sciences, 1996
... primary antibodies were used: rabbit polyclonal antibody to PKCζ (C-20) (SC-216), rabbit polyclonal antibody to GST (Z-5, SC-459) (Santa Cruz Biotechnology), rabbit polyclonal antibody to ...
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70
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Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1995
... -transferase (GST) mAb were purchased from Santa Cruz Biotechnology.
Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein
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Braun Peter E. et al., In The Journal of Cell Biology, 1992
... (Sternberger); CNP pAb (R422; affinity purified); G-actin, α-tubulin, and β-tubulin mAbs (ICN Biomedicals); His and GST tag mAbs (GE Healthcare); tubulin pAb (Santa Cruz Biotechnology, Inc.); control IgG, acetylated ...
Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies.
Supplier
Bhatia Mick, In PLoS ONE, 1991
... against mouse Podocalyxin (MBL, Woburn MA), and polyclonal rabbit antibodies against NHERF-1 (EBP50: Abcam) and GST (Santa Cruz Biotechnology, Santa Cruz, CA) ...
Footprinting DNA-protein complexes in situ following gel retardation assays using 1,10-phenanthroline-copper ion: Escherichia coli RNA polymerase-lac promoter complexes.
Supplier
Mukhopadhyay Gauranga et al., In BMC Biochemistry, 1986
... Coding sequence of human Cdc6 was cloned in pFastBac-GST vector (Life Technologies, Inc.) to express GST ...
Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose
Supplier
Johannes Ludger, In PLoS ONE, 1983
... Signaling Technology); mouse anti-GM130 antibody (BD Transduction Laboratories); Alexa 488-conjugated anti-GST antibody (Molecular Probes); mouse anti-GST antibody (Cell Signaling Technology) ...
A simple method for displaying the hydropathic character of a protein.
Supplier
Imperiale Michael J., In PLoS Pathogens, 1981
... genome, pJC1->4pJCV [VG015, Health Science Research Resources Bank (HSRRB)] and subcloned into a pGST-EGFP plasmid including GST into the Kpn I and Bam HI sites of pEGFP-N1 (Clontech Mountain View, CA); pCXSN ...
TAIR7 Arabidopsis Genome Annotation
Supplier
Hilson Pierre et al., In BMC Bioinformatics, 1980
... The numbering of both short GST and GFT IDs is random ...
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
Supplier
Khanin Raya, In PLoS ONE, 1975
... X), rabbit polyclonal anti-Sp1 (sc-14027 X), rabbit polyclonal anti-Sp3 (sc-644 X), rabbit polyclonal anti glutathione-S-transferase (GST) (sc-459) and normal goat IgG (sc-2028) were from Santa Cruz Biotechnology.
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