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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutathione S-transferase, pi 1

GST-pi, mGSTP1
Top mentioned proteins: GST, HAD, CD45, CAN, MDR1
Papers on GST-pi
A simple histological technique to improve immunostaining when using DNA denaturation for BrdU labelling.
Messier et al., Ottawa, Canada. In J Neurosci Methods, Mar 2016
We used a GFP anti-EYFP antibody to maximize visualization of the EYFP-containing oligodendrocyte progenitor cells, Olig1, and GST-pi to confirm the cell phenotype.
Phosphodiesterase-5 inhibition promotes remyelination by MCP-1/CCR-2 and MMP-9 regulation in a cuprizone-induced demyelination model.
Peixoto et al., Recife, Brazil. In Exp Neurol, Jan 2016
CPZ induced an increase in the expression of IL-1β and a decrease in MCP-1, CCR-2, MBP and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath.
Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats.
Uysal et al., İstanbul, Turkey. In Int J Immunopathol Pharmacol, Jan 2016
Protein and mRNA expressions of glutathione transferase-pi (GST-pi) were evaluated as a marker of preneoplastic lesions.
Fisetin Modulates Antioxidant Enzymes and Inflammatory Factors to Inhibit Aflatoxin-B1 Induced Hepatocellular Carcinoma in Rats.
Trigun et al., Benares, India. In Oxid Med Cell Longev, Dec 2015
These observations were consistent with the regression of neoplastic lesion and declined GST-pi (placental type glutathione-S-transferase) level, a HCC marker, in the liver of the Fisetin treated HCC rats.
Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin.
Ozer et al., Ankara, Turkey. In Protein J, Dec 2015
It is known that isoenzymes of GST and especially GST-pi is increased in cancer cells and it plays very important functions in the development of resistance to anticancer drugs.
Glutathione S-transferase pi (GST-pi) inhibition and anti-inflammation activity of the ethyl acetate extract of Streptomyces sp. strain MJM 8637.
Suh et al., South Korea. In Saudi J Biol Sci, Nov 2015
To investigate the anti-cancer properties of soil-borne actinobacteria, MJM 8637, the glutathione S-transferase pi (GST-pi) assay, anti-tumor necrosis factor (TNF)-α assay, the level of antioxidant potential by DPPH radical scavenging activity, NO scavenging activity, and ABTS radical scavenging activity in ethyl acetate extract were determined.
Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1.
Sheu et al., Taiwan. In Am J Chin Med, 2014
Nontoxic EEAC and its active ingredients decreased ERp57, GLUD-1, GST-pi, and PGK-1 protein expressions.
Effect of Ginkgo biloba extract on the expressions of Cox-2 and GST-Pi in rats with hepatocellular carcinoma risk.
Li et al., Nanning, China. In Afr Health Sci, 2014
OBJECTIVES: To explore the effect of EGb on expressions of cyclooxygenase-2 (Cox-2) and glutathione S-transferase Pi (GST-Pi) in the pathogenesis of HCC.
Organ specific Gst-pi expression of the metastatic androgen independent prostate cancer cells in nude mice.
Shirai et al., Nagoya, Japan. In Prostate, 2012
Gst-pi expression of the prostate cancers are dependent on metastatic site.
Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes.
Richardson et al., Sydney, Australia. In J Biol Chem, 2012
DNIC storage function of GST P1-1 and ability of MRP1 to efflux DNICs are vital in protection against NO cytotoxicity
Increased skin papilloma formation in mice lacking glutathione transferase GSTP.
Wolf et al., Dundee, United Kingdom. In Cancer Res, 2011
GSTP plays a major role in carcinogenesis distinct from its role in detoxification and provides evidence that the enzyme is a key determinant of the proinflammatory tumor environment.
The many faces of glutathione transferase pi.
Vasieva, Liverpool, United Kingdom. In Curr Mol Med, 2011
Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to several cancers, asthma and neurodegenerative disorders.
Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for 'ping pong' kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione.
Mantle et al., Dublin, Ireland. In Febs J, 2011
This study analysed the kinetic behaviour of all the various cysteine to alanine mutants of Gstp1. These mutations introduce cooperativity and a novel 'ping pong' mechanism in the case of the C169A mutant.
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer.
Stewart, Houston, United States. In Crit Rev Oncol Hematol, 2010
Equivocal data (with some positive studies but other negative studies) suggest that NSCLC tumors with some EGFR mutations may have increased sensitivity to chemotherapy, while K-ras mutations and expression of GST-pi, RB or p27kip1 may possibly confer resistance.
Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids.
Bhatnagar et al., Louisville, United States. In J Biol Chem, 2010
Sequential catalysis of Aldr1 by glutathione S-transferase P and glutaredoxin may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines regulates the reduction of protein sulfenic acids to cysteines
Cell death and autophagy: cytokines, drugs, and nutritional factors.
Gerner et al., Vienna, Austria. In Toxicology, 2009
Protein analysis during autophagic cell death revealed distinct proteins of the nuclear fraction including GST-pi and some proteasomal subunit constituents to be affected during autophagic cell death.
The use of glutathione transferase-knockout mice as pharmacological and toxicological models.
Board, Canberra, Australia. In Expert Opin Drug Metab Toxicol, 2007
So far, mice have been generated with deficiencies of mGSTP1/2, mGSTA4-4, mGSTZ1-1, mGSTM1-1, mGSTO1-1 and mGSTS1-1, but studies of drug metabolism in these strains have been limited.
Novel cytotoxic agents for non-small cell lung cancer.
Edelman, Baltimore, United States. In J Thorac Oncol, 2006
TLK-286 is a novel agent that may enhance the activity of previously available agents by inhibiting GST-pi, a detoxifying mechanism that may be of particular relevance to platinum agents.
Clinical Significance of p53, P-glycoprotein, and Glutathione S transferase-pi in Advanced Non-Small Cell Lung Cancer.
Sohn et al., In Cancer Res Treat, 2002
PURPOSE: A retrospective study was performed o define the clninical significance of p53, P-glycoprotein (Pgp), and Glutathione S transferase-pi (GST-pi) immunohistochemical (IHC) expression in advanced non-small cell lung cancer (NSCLC).
Expression of P-glycoprotein and glutathione-S-transferase in recurrent lymphomas: the possible role of Epstein-Barr virus, immunophenotypes, and other predisposing factors.
Wang et al., Taipei, Taiwan. In J Clin Oncol, 1993
Expression of a multidrug resistance P-glycoprotein ([P-gp]mdr-1) and a glutathione redox cycle-related glutathione-S-transferase pi (GST-pi) was determined by an immunohistochemistry method.
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