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proteins. Page last changed on 14 Mar 2013.
Glycogen synthase kinase 3 alpha
GSK-3alpha, glycogen synthase kinase 3alpha
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011] (from
NCBI)
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Papers on
GSK-3alpha
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.
GeneRIF
Cincinnati, United States. In Proc Natl Acad Sci U S A, 2011
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.
MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma.
GeneRIF
Hefei, China. In Proc Natl Acad Sci U S A, 2011
Data show that p53 directly up-regulates microRNA-149* (miR-149*) that in turn targets glycogen synthase kinase-3alpha, resulting in increased expression of Mcl-1 and resistance to apoptosis in melanoma cells.
GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubules.
GeneRIF
Baltimore, United States. In Genes Dev, 2011
lattice-binding activity mediates axon growth inhibition induced by suppression of GSK3 activity via preventing microtubule protrusion into the growth cone periphery
Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages.
GeneRIF
Oklahoma City, United States. In Infect Immun, 2011
The authors demonstrate that inhibition of GSK-3 dampens Bacillus anthracis edema toxin-induced maturation and migration processes of monocyte-derived dendritic cells.
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.
Impact
GeneRIF
Cambridge, United Kingdom. In Nat Cell Biol, 2011
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.
Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating occludin, claudin-1 and E-cadherin expression.
Atlanta, United States. In Biochem Biophys Res Commun, 2010
Reduction of GSK-3 activity, either by small molecule inhibitors or siRNA targeting GSK-3 alpha and beta mRNA, resulted in increased permeability to both ions and bulk solutes.
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
Philadelphia, United States. In J Clin Invest, 2010
Herein, we present what we believe to be the first studies defining the role of GSK-3alpha in the mouse heart using gene targeting.
Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes.
Toronto, Canada. In Mol Endocrinol, 2010
Phosphorylation of Akt substrates glycogen synthase kinase 3alpha and -beta were unaltered by AICAR, indicating that the AMPK-regulatory effects were specific to the AS160/TBC1D4 signaling pathway.
Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis.
GeneRIF
Jerusalem, Israel. In Mol Endocrinol, 2010
Glycogen synthase kinase (GSK3) plays a central role in promoting glucocorticoid-induced apoptosis.
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.
Montpellier, France. In Mol Cancer Ther, 2010
Increased de novo fatty acid (FA) synthesis is one hallmark of tumor cells, including prostate cancer.
GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism.
GeneRIF
Birmingham, United States. In Plos One, 2009
impaired inhibitory regulation of GSK3 in Fmr1 knockout mice may contribute to some socialization deficits
Hyperactivity and enhanced curiosity of mice expressing PKB/SGK-resistant glycogen synthase kinase-3 (GSK-3).
Tübingen, Germany. In Cell Physiol Biochem, 2009
METHODS: Gene-targeted knockin mice with mutated and thus PKB/SGK-resistant GSK-3alpha, beta (gsk-3(KI)) were compared to corresponding wild type mice (gsk-3(WT)).
Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms.
Grenoble, France. In Plos One, 2009
The inhibitory effect of nitration on Akt activity was confirmed by the ability of SIN-1 to completely block GSK3alpha phosphorylation in vitro.
Molecular mechanisms of thrombopoietin signaling.
Review
San Diego, United States. In J Thromb Haemost, 2009
Additional signals activated by these secondary mediators include mammalian target of rapamycin, beta-catenin, hypoxia-inducible factor 1alpha and the homeobox proteins HOXB4 and HOXA9, and a number that are reduced, including glycogen synthase kinase 3alpha and the FOXO3 family of forkhead proteins.
GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics.
Review
Miyazaki, Japan. In Front Biosci, 2008
GSK-3 alpha (51 kDa)/-3 beta (47 kDa) are encoded by different genes.
Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis.
Review
London, United Kingdom. In Br J Pharmacol, 2008
Glycogen synthase kinase 3 (GSK3, of which there are two isoforms, GSK3alpha and GSK3beta) was originally characterized in the context of regulation of glycogen metabolism, though it is now known to regulate many other cellular processes.
Mechanisms regulating the susceptibility of hematopoietic malignancies to glucocorticoid-induced apoptosis.
Review
Jerusalem, Israel. In Adv Cancer Res, 2007
Shifting the balance of the kinome towards a state where Glycogen synthase kinase 3alpha (GSK3alpha) is kept active, favors an apoptotic response.
Role of polyglycine repeats in the regulation of glycogen synthase kinase activity.
Review
Madrid, Spain. In Protein Pept Lett, 2007
Glycogen synthase kinase (GSK3) activity present in one cell is the consequence of the sum of the activities of two different proteins called GSK3alpha and GSK3beta.
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.
Impact
GeneRIF
Toronto, Canada. In Cell Metab, 2007
GSK-3alpha knockout (GSK-3alpha KO) animals are viable but display enhanced glucose and insulin sensitivity accompanied by reduced fat mass.
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.
Impact
GeneRIF
Philadelphia, United States. In Nature, 2003
Paper shows that GSK-3 isoforms are not functionally equivalent in regulating the production of Abeta peptides. siRNA used to knockdown endogenous GSK-3 isoforms in cultured cells.
