Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice.
Omaha, United States. In Mol Neurobiol, Aug 2015
To examine the role of GSK-3 in astrocytes, we generated a conditional knockout mouse using a glial fibrillary acidic protein (GFAP)-cre driver, in which the GSK-3 alpha and beta genes are deleted in astrocytes.
TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.
Columbia, United States. In J Biol Chem, 2010
Western blot analyses revealed decreases in p-phospholamban, SERCA2a, p-CX43, p-GSK-3alpha/beta, nuclear beta-catenin, GATA4, NFATc3/c4, and increased NCX1, nuclear DYKR1A, and Pur alpha/beta protein.