gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

GSS glutathione synthetase

GSH S
Top mentioned proteins: GST, ACID, CAN, HAD, catalase
Papers on GSH S
Identification of glutathione conjugates of acetylene-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5.
New
Johnson et al., United States. In Drug Metab Dispos, Apr 2015
Subsequent analysis by NMR showed that GSH had reacted with the acetylene carbon atoms of these mGluR5 PAMs, suggesting a conjugate addition mechanism and implicating cytosolic and microsomal GSH S-transferases (GSTs) in catalysis.
Comparative proteomic analysis revealing the complex network associated with waterlogging stress in maize (Zea mays L.) seedling root cells.
Qiu et al., Wuhan, China. In Proteomics, 2015
In the waterlogged A3237 root cells, NADP-malic enzyme, glutamate decarboxylase, coproporphyrinogen III oxidase, GSH S-transferase, GSH dehydrogenase, and xyloglucan endotransglycosylase 6 were specifically accumulated to manage energy consumption, maintain pH levels, and minimize oxidative damage.
Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation.
Galli et al., Perugia, Italy. In Free Radic Biol Med, 2015
Experiments carried out in GSH S-transferase P (GSTP)-overexpressing K562 human erythroleukemia cells and in GSTP1-1-knockout murine embryonic fibroblasts (MEFs) demonstrated that this cytosolic enzyme represents a preferential target of the redox disturbances produced by this Se-compound with a key role in controlling H2O2 generation and the perturbation of stress/survival kinase signaling.
The glutathione system: a new drug target in neuroimmune disorders.
Review
Maes et al., Llanelli, United Kingdom. In Mol Neurobiol, 2014
Glutathione (GSH) has a crucial role in cellular signaling and antioxidant defenses either by reacting directly with reactive oxygen or nitrogen species or by acting as an essential cofactor for GSH S-transferases and glutathione peroxidases.
Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.
Review
Rusyn et al., In Mutat Res Rev Mutat Res, 2014
Experimental animal and human data indicate that TCE metabolism occurs through two major pathways: cytochrome P450 (CYP)-dependent oxidation and glutathione (GSH) conjugation catalyzed by GSH S-transferases (GSTs).
Effect of CIK on multidrug-resistance reversal and increasing the sensitivity of ADR in K562/ADR cells.
Liu et al., Tianjin, China. In Oncol Lett, 2014
A decreased level of P-glycoprotein expression and glutathione (GSH), an increased intracellular Rh-123 content, decreased mRNA and protein expression levels of MDR gene 1, MDR-associated protein 1, GSH S-transferase-π, B-cell lymphoma 2 and Survivin, and the decreased phosphorylation of AKT and the transcriptional activity of nuclear factor-κB and activator protein 1 were detected following ADR treatment in CIK co-cultured K562/ADR cells.
[Oral exposure of fluorochloridone caused testes damage of Sparague-Dawley rats].
Zhou et al., Shanghai, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2014
RESULTS: Compared with the control group, the 750 mg/kg FLC group had significantly lower testicular weight and organ coefficient, epididymal weight, and cauda epididymal sperm count (P < 0.05 or P < 0.01), the 150 and 750 mg/kg FLC groups had significantly increased malonaldehyde content (P < 0.05 or P < 0.01), each exposed group had a significantly reduced glutathione (GSH) level (P < 0.05 or P < 0.01), the 750 mg/kg FLC group had significantly reduced activities of superoxide dismutase (SOD), catalase (CAT), GSH peroxidase, GSH S-transferase (GSH-ST), and GSH reductase (GSH-GR) (P < 0.05 or P < 0.01), the 150 mg/kg FLC group showed significant decreases in the activities of all antioxidant enzymes except GSH-GR (P < 0.05 or P < 0.01), and the 30 mg/kg FLC group showed significant decreases in the activities of SOD and CAT (P < 0.05 or P < 0.01).
The novel arsenical darinaparsin is transported by cystine importing systems.
Miller et al., Montréal, Canada. In Mol Pharmacol, 2014
Overall, our data support a model where Dar, a GSH S-conjugate, is processed at the cell surface by γ-GT, leading to formation of DMAC, which is imported via xCT, xAG, or potentially other cystine/cysteine importing systems.
Blood thiol status and erythrocyte glutathione-S-transferase in chronic kidney disease patients on treatment with frequent (daily) hemodialysis.
Buoncristiani et al., Perugia, Italy. In Free Radic Res, 2014
BACKGROUND: Chronic kidney disease (CKD) is a condition of impaired homeostasis of blood thiols characterized by a severe hyperhomocysteinemia (HH) and abnormal expression of the red blood cell glutathione (GSH)-consuming enzyme GSH S-transferase (eGST) (Galli et al., Clin Chem 1999).
Characterization of the phytochelatin synthase from the human parasitic nematode Ancylostoma ceylanicum.
Williams et al., Chicago, United States. In Mol Biochem Parasitol, 2013
Phytochelatin synthase proteins also function in the elimination of xenobiotics by processing GSH S-conjugates.
Induction of Nrf2-dependent Antioxidation and Protection Against Carbon Tetrachloride-induced Liver Damage by Andrographis Herba (chuān xīn lián) Ethanolic Extract.
Lii et al., Taiwan. In J Tradit Complement Med, 2012
The results showed that APE increased hepatic glutathione (GSH) content and superoxide dismutase, GSH peroxidase, and GSH S-transferase activities in a dose-dependent manner (p < 0.05).
Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract.
GeneRIF
Guembe et al., Pamplona, Spain. In Ann N Y Acad Sci, 2005
PrP(c) is expressed in all digestive regions of the rat, monkey, and cow; PrP(c) expressing cells appeared scattered throughout the epithelium of fundic and pyloric glands as well as in intestinal villi and crypts.
Glutathione, altruistic metabolite in fungi.
Review
Penninckx et al., Debrecen, Hungary. In Adv Microb Physiol, 2003
GSH S-conjugates may also form in a glutathione S-transferases-independent way, e.g. through chemical reaction between GSH and the antifugal agent Thiram.
Cadmium adaptation in the lung - a double-edged sword?
Review
Watkin et al., Burlington, United States. In Toxicology, 2001
Increased levels of glutathione (GSH) and induction of enzymes involved with both the synthesis of GSH (gamma-glutamylcysteine synthetase regulatory and catalytic subunits) and its metabolism (GSH S-transferases) also constitute important components of the pulmonary adaptive response.
Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl esters.
Review
Lange et al., Saint Louis, United States. In Alcohol Clin Exp Res, 1993
cDNA cloning demonstrates two of these enzymes to be GSH S-transferases and has enabled initiation of genetic studies of alcohol-induced CNS injury.
The role of nutritional factors in the prevention of peroxidative damage to tissues.
Cowey, Aberdeen, United Kingdom. In Fish Physiol Biochem, 1986
In rainbow trout depleted of Se there was a compensatory increase in hepatic GSH S-transferase activity.
share on facebooktweetadd +1mail to friends