Variability in long-term hepatitis B virus dynamics under antiviral therapy.
Sydney, Australia. In J Theor Biol, Jan 2016
Serum viral dynamics differentiated the patients into four response groups dependent on how quickly viremia became undetectable: quickly suppressed (HBV DNA <100 copies/ml within 8 weeks and staying suppressed, GRP1); quickly suppressed but some rebound (<10,000 copies/ml, GRP2); slow decay (GRP3); virological failures (>10,000 copies/ml, GRP4).
Expression pattern of class I phosphoinositide 3-kinase and distribution of its product, phosphatidylinositol-3,4,5-trisphosphate, during Drosophila embryogenesis.
Maebashi, Japan. In Gene Expr Patterns, 2014
The expression pattern of the class I PI3K and distribution of PI(3,4,5)P(3), visualized by its specific binding protein, GRP1-PH, were examined during Drosophila embryogenesis.
Molecular mechanism of membrane binding of the GRP1 PH domain.
Chicago, United States. In J Mol Biol, 2013
The pleckstrin homology (PH) domain of the general receptor of phosphoinositides 1 (GRP1) protein selectively binds to a rare signaling phospholipid, phosphatidylinositol (3,4,5)-trisphosphate (PIP3), in the membrane.
Gastrin-releasing peptide: different forms, different functions.
Melbourne, Australia. In Biofactors, 2009
Amidated GRP18-27, which together with amidated GRP1-27 was long thought to be the only biologically relevant product of the GRP gene, is involved in a multitude of physiological functions and acts as a mitogen, morphogen, and proangiogenic factor in certain cancers.
A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases.
Indianapolis, United States. In Prog Nucleic Acid Res Mol Biol, 2001
It also details our current knowledge about the regulation and function of this rapidly growing family of enzymes that include Sos1 and 2, GRF1 and 2, CalDAG-GEF/GRP1-4, C3G, cAMP-GEF/Epac 1 and 2, PDZ-GEFs, MR-GEF, RalGDS family members, RalGPS, BCAR3, Smg GDS, and phospholipase C(epsilon).