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Cytohesin 3

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bombesin, Gastrin, CAN, Insulin, ACID
Papers on GRP1
Variability in long-term hepatitis B virus dynamics under antiviral therapy.
Dandri et al., Sydney, Australia. In J Theor Biol, Jan 2016
Serum viral dynamics differentiated the patients into four response groups dependent on how quickly viremia became undetectable: quickly suppressed (HBV DNA <100 copies/ml within 8 weeks and staying suppressed, GRP1); quickly suppressed but some rebound (<10,000 copies/ml, GRP2); slow decay (GRP3); virological failures (>10,000 copies/ml, GRP4).
Can textured insoles improve ankle proprioception and performance in dancers?
Tirosh et al., Melbourne, Australia. In J Sports Sci, Dec 2015
In the first 5 weeks (weeks 1 to 5), the first intervention group (GRP1) was asked to wear textured insoles in their ballet shoes and the second intervention group (GRP2) was not given textured insoles to wear.
Does Wearing Textured Insoles during Non-class Time Improve Proprioception in Professional Dancers?
Waddington et al., Canberra, Australia. In Int J Sports Med, Nov 2015
During the first 4 weeks, the first intervention group (GRP1) was asked to wear textured insoles in their sports shoes during non-class periods, and the second intervention group (GRP2) followed standard practice.
Expression pattern of class I phosphoinositide 3-kinase and distribution of its product, phosphatidylinositol-3,4,5-trisphosphate, during Drosophila embryogenesis.
Izumi et al., Maebashi, Japan. In Gene Expr Patterns, 2014
The expression pattern of the class I PI3K and distribution of PI(3,4,5)P(3), visualized by its specific binding protein, GRP1-PH, were examined during Drosophila embryogenesis.
Bioluminescent probes to analyze ligand-induced phosphatidylinositol 3,4,5-trisphosphate production with split luciferase complementation.
Ozawa et al., Tokyo, Japan. In Anal Chem, 2014
A C-terminal fragment of a luciferase fused with PIP3 binding units, pleckstrin homology domains (PHDs) of the general receptor for phosphoinositides 1 (GRP1), was expressed in cytosol (PP-LucC).
Molecular mechanism of membrane binding of the GRP1 PH domain.
Voth et al., Chicago, United States. In J Mol Biol, 2013
The pleckstrin homology (PH) domain of the general receptor of phosphoinositides 1 (GRP1) protein selectively binds to a rare signaling phospholipid, phosphatidylinositol (3,4,5)-trisphosphate (PIP3), in the membrane.
PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains.
Shears et al., United States. In Biochem J, 2013
This rank order of ligand competition with PtdIns(3,4,5)P3 was also exhibited by the PH (pleckstrin homology) domains of Akt (also known as protein kinase B), GRP1 (general receptor for phosphoinositides 1) and SIN1 (stress-activated protein kinase-interaction protein 1).
Degree of Acute Kidney Injury before Dialysis Initiation and Hospital Mortality in Critically Ill Patients.
Render et al., Cincinnati, United States. In Int J Nephrol, 2012
AKI-D was categorized into four groups (Grp) based on creatinine elevation after ICU admission but before dialysis initiation: Grp I  > 0.3 mg/dL to <2-fold increase, Grp II ≥2 times but <3 times increase, Grp III ≥3-fold increase in creatinine, and Grp IV none or <0.3 mg/dl increase.
Finding a needle in a haystack: the role of electrostatics in target lipid recognition by PH domains.
Sansom et al., Oxford, United Kingdom. In Plos Comput Biol, 2011
We investigate the mechanism of such recognition via a multiscale procedure combining Brownian dynamics (BD) and molecular dynamics (MD) simulations of the GRP1 PH domain interacting with phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P₃).
The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).
Falke et al., Boulder, United States. In Biochemistry, 2011
incorporation of the E345K charge reversal mutation into the GRP1 PH domain enhances PI(4,5)P(2) affinity 8-fold and yields constitutive plasma membrane targeting in cells
Getting a GRASP on CASP: properties and role of the cytohesin-associated scaffolding protein in immunity.
Pohajdak et al., Halifax, Canada. In Immunol Cell Biol, 2009
Interestingly, an evolutionarily related neuronal protein, called GRP1-associated scaffolding protein, may further participate in CASP-related functions in immune cells, conferring a level of redundancy in associated molecular pathways.
Gastrin-releasing peptide: different forms, different functions.
Baldwin et al., Melbourne, Australia. In Biofactors, 2009
Amidated GRP18-27, which together with amidated GRP1-27 was long thought to be the only biologically relevant product of the GRP gene, is involved in a multitude of physiological functions and acts as a mitogen, morphogen, and proangiogenic factor in certain cancers.
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.
Lambright et al., Worcester, United States. In Mol Cell, 2007
These observations suggest that Grp1 family guanine nucleotide exchange factors are autoregulated by mechanisms that depend on plasma membrane recruitment for activation.
General receptor for phosphoinositides 1, a novel repressor of thyroid hormone receptor action that prevents deoxyribonucleic acid binding.
Langlois et al., Sherbrooke, Canada. In Mol Endocrinol, 2005
GRP1 is a new corepressor for thyroid hormone receptors, which modulates both positive and negative regulation by T3 by decreasing TR-complex formation on thyroid response elements
The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi.
Munro et al., Cambridge, United Kingdom. In J Cell Biol, 2004
Arf1p and Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi
A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases.
Castro et al., Indianapolis, United States. In Prog Nucleic Acid Res Mol Biol, 2001
It also details our current knowledge about the regulation and function of this rapidly growing family of enzymes that include Sos1 and 2, GRF1 and 2, CalDAG-GEF/GRP1-4, C3G, cAMP-GEF/Epac 1 and 2, PDZ-GEFs, MR-GEF, RalGDS family members, RalGPS, BCAR3, Smg GDS, and phospholipase C(epsilon).
Glycine-rich proteins as structural components of plant cell walls.
Ryser et al., Zürich, Switzerland. In Cell Mol Life Sci, 2001
Specific digestion of GRP1.8 from bean by collagenase suggests that it shares structural similarities with collagen.
Potential regulation of ADP-ribosylation factor 6 signalling by phosphatidylinositol 3,4,5-trisphosphate.
Venkateswarlu et al., Bristol, United Kingdom. In Biochem Soc Trans, 1999
In this review we have described data supporting the conclusion that PtdIns(3,4,5)P3 may regulate the activation state of ARF6 through an ability to recruit the ARF exchange factors ARNO, GRP1 and cytohesin-1 to the plasma membrane.
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains.
Czech et al., Worcester, United States. In Science, 1997
GRP1 binds phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4, 5)P3] through a pleckstrin homology (PH) domain and displays a region of high sequence similarity to the yeast Sec7 protein.
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