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Growth hormone 1

Growth Hormone
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, Insulin, Insulin-Like Growth Factor I, HAD, CAN
Papers on Growth Hormone
Variability in adherence to rhGH treatment: Socioeconomic causes and effect on children's growth.
New
Bel et al., Barcelona, Spain. In Growth Horm Igf Res, Feb 2016
BACKGROUND: In children with growth disorders, mean final height is associated to poor adherence to Growth Hormone therapy.
Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.
New
Creemers et al., Leuven, Belgium. In Int J Obes (lond), Feb 2016
Growth hormone expression and IGF1 levels were normal, indicating near-normal processing of hypothalamic proGHRH.
Pharmacotherapy for mental health problems in people with intellectual disability.
New
Findling et al., Baltimore, United States. In Curr Opin Psychiatry, Feb 2016
Growth hormone treatment might improve cognition and behavior in Prader-Willi syndrome population.
Growth And The Growth Hormone-Insulin Like Growth Factor 1 Axis In Children With Chronic Inflammation: Current Evidence, Gaps In Knowledge And Future Directions.
New
Impact
Ahmed et al., Glasgow, United Kingdom. In Endocr Rev, Jan 2016
These factors can impair growth by their effects on the growth hormone-insulin like growth factor axis and also directly at the level of the growth plate via alterations in chondrogenesis and local growth factor signaling.
Coming Up Short: Risks of Bias in Assessing Psychological Outcomes in Growth Hormone Therapy for Short Stature.
Review
New
Sandberg et al., Minneapolis, United States. In J Clin Endocrinol Metab, Jan 2016
CONTEXT: Two often cited assumptions for treating children with GH are that short stature (SS), as an isolated physical characteristic, is associated with psychosocial morbidity and that GH treatment may increase height and improve psychological adjustment.
The Effect of Recombinant Growth Hormone Treatment in Children with Idiopathic Short Stature and Low Insulin-Like Growth Factor-1 Levels.
New
Berberoğlu et al., Ankara, Turkey. In J Clin Res Pediatr Endocrinol, Jan 2016
Recombinant growth hormone (rGH) treatment has been used by some authors with variable results.
Long-Acting Growth Hormone: An Update.
Review
New
Mejia-Corletto et al., In Endocr Dev, Dec 2015
After the introduction of recombinant human growth hormone (rhGH) in 1985, a myriad of children and adults have benefited from its growth-promoting and metabolic effects.
Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays.
New
Sandros et al., Greensboro, United States. In J Vis Exp, Dec 2015
Sensitive and selective methods for the detection of human growth hormone (hGH) over a wide range of concentrations (high levels of 50-100 ng ml(-) (1) and minimum levels of 0.03 ng ml(-) (1)) in circulating blood are essential as variable levels may indicate altered physiology.
Growth hormone binding protein - Physiological and analytical aspects.
Review
New
Bidlingmaier et al., München, Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
A significant proportion of total circulating growth hormone (GH) is bound to a high affinity growth hormone binding protein (GHBP).
Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3).
Review
New
Abizaid et al., Ottawa, Canada. In Eneuro, Mar 2015
The growth hormone secretagogue receptor (GHSR1a), the target of the ghrelin peptide, is widely distributed throughout the brain, and, while studies have often reported very low or absent levels of central ghrelin, it is now known that GHSR1a, even in the absence of a natural ligand, has physiological roles.
Meier-Gorlin syndrome.
Review
Bongers et al., Nijmegen, Netherlands. In Orphanet J Rare Dis, 2014
Growth hormone treatment is ineffective in most patients with MGS, but may be effective in patients in whom growth continues to decrease after the first year of life (usually growth velocity normalizes after the first year) and with low levels of IGF1.
Idiopathic short stature: a clinical review.
Review
Impact
Cohen, Boston, United States. In Jama, 2014
Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial.
Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications.
Review
Impact
Chanson et al., Le Kremlin-Bicêtre, France. In Endocr Rev, 2014
Besides their growth-promoting properties, GH and IGF-1 regulate a broad spectrum of biological functions in several organs, including the kidney.
Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand.
Impact
Lovell-Badge et al., London, United Kingdom. In Cell Stem Cell, 2013
Pituitary hormone deficiencies, with Growth Hormone deficiency being most frequent (1 in 3,500-10,000 births), cause significant morbidity.
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.
Review
Impact
Longo et al., Springfield, United States. In Physiol Rev, 2013
Growth hormone (GH) is a key determinant of postnatal growth and plays an important role in the control of metabolism and body composition.
DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function.
GeneRIF
Liebhaber et al., Philadelphia, United States. In J Biol Chem, 2012
These data establish HSII as a nonredundant component of the hGH LCR essential for establishment of robust levels of hGH-N gene expression
Effect of recombinant human growth hormone and interferon gamma on hepatic collagen synthesis and proliferation of hepatic stellate cells in cirrhotic rats.
GeneRIF
Mai et al., Chengdu, China. In Hepatobiliary Pancreat Dis Int, 2012
Recombinant human growth hormone increased collagen synthesis and promoted hepatic stellate cell proliferation in liver cirrhosis.
The characteristics of acromegalic patients with hyperprolactinemia and the differences in patients with merely GH-secreting adenomas: clinical analysis of 279 cases.
GeneRIF
Xu et al., Jinan, China. In Eur J Endocrinol, 2012
Compared with patients with merely GH-secreting adenomas, acromegalic patients with hyperprolactinemia are characterized by an earlier onset of disease, lesser acromegalic features, lower GH levels, but larger tumor sizes.
Janus kinase (JAK) 2 V617F mutation as the cause of primary thrombocythemia in acromegaly with severe visceromegaly and divergence between growth hormone and insulin-like growth factor-1 concentrations during the follow-up: causal or casual association?
GeneRIF
Giordano et al., Palermo, Italy. In Growth Horm Igf Res, 2012
Janus kinase (JAK) 2 V617F mutation may have a role in primary thrombocythemia in acromegaly with severe visceromegaly and divergence between growth hormone and insulin-like growth factor-1 concentrations during the follow-up
The effect of prolonged fasting on levels of growth hormone-binding protein and free growth hormone.
GeneRIF
Frystyk et al., Cambridge, United Kingdom. In Growth Horm Igf Res, 2012
GHBP plays a role in limiting variations of circulating free GH levels
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