Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3).
Ottawa, Canada. In Eneuro, Mar 2015
The growth hormone secretagogue receptor (GHSR1a), the target of the ghrelin peptide, is widely distributed throughout the brain, and, while studies have often reported very low or absent levels of central ghrelin, it is now known that GHSR1a, even in the absence of a natural ligand, has physiological roles.
Nijmegen, Netherlands. In Orphanet J Rare Dis, 2014
Growth hormone treatment is ineffective in most patients with MGS, but may be effective in patients in whom growth continues to decrease after the first year of life (usually growth velocity normalizes after the first year) and with low levels of IGF1.