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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Growth hormone releasing hormone

Growth Hormone-Releasing Hormone, GHRH, growth hormone-releasing factor
The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: somatostatin, Insulin-Like Growth Factor I, Insulin, ghrelin, HAD
Papers on Growth Hormone-Releasing Hormone
Growth hormone releasing hormone excess and blockade in X-LAG syndrome.
New
Beckers et al., Brussels, Belgium. In Endocr Relat Cancer, Jan 2016
In individual cases random GH-releasing hormone (GHRH) levels have been elevated.
GHRH Receptor Expression in Malignant Mixed Müllerian Tumors: A Potentially Targetable Biopredictor.
New
Nadji et al., Miami, United States. In Int J Gynecol Pathol, Dec 2015
Growth hormone-releasing hormone (GHRH) is produced by a variety of malignant tumors and acts as a growth factor in an autocrine/paracrine manner.
In vitro effects of somatostatin on the growth hormone-insulin-like growth factor axis in orange-spotted grouper (Epinephelus coioides).
New
Li et al., Guangzhou, China. In Gen Comp Endocrinol, Nov 2015
UNASSIGNED: Growth in vertebrates is mainly mediated by the growth hormone (GH)-insulin-like growth factor (IGF) axis, and somatostatin (SRIF) inhibits growth by decreasing GH release at the pituitary level and antagonizing the release and action of GHRH in the hypothalamus.
Nutrient Sensing Overrides Somatostatin and Growth Hormone-Releasing Hormone to Control Pulsatile Growth Hormone Release.
Review
New
Steyn, Australia. In J Neuroendocrinol, Jul 2015
Pharmacological studies reveal that interactions between hypothalamic inhibitory somatostatin and stimulatory growth hormone-releasing hormone (GHRH) govern pulsatile GH release.
The Non-Thyroidal Illness Syndrome
Review
New
DeGroot, Madagascar. In Unknown Journal, Mar 2015
The best form of treatment (TRH,TSH,or T3+T4) and possible accompanying treatments (GHRH, Cortisol, nutrition, insulin) lack consensus.
Cell-Penetrating Ability of Peptide Hormones: Key Role of Glycosaminoglycans Clustering.
Bourgault et al., Montréal, Canada. In Int J Mol Sci, 2014
This 38-residue polycationic peptide is a member of the secretin/glucagon/growth hormone-releasing hormone (GHRH) superfamily, with which PACAP38 shares high structural and conformational homologies.
GHRH, PRP-PACAP and GHRHR Target Sequencing via an Ion Torrent Personal Genome Machine Reveals an Association with Growth in Orange-Spotted Grouper (Epinephelus coioides).
Lin et al., Guangzhou, China. In Int J Mol Sci, 2014
Growth hormone-releasing hormone (GHRH) and the receptor, GHRHR, constitute important components of the hypothalamus-pituitary growth axis and act on the downstream growth hormone (GH).
Normal Physiology of ACTH and GH Release in the Hypothalamus and Anterior Pituitary in Man
Review
Khoo et al., Madagascar. In Unknown Journal, 2014
The primary hypophysiotropic factors influencing GH production and secretion are GH releasing hormone (GHRH), somatostatin and the more recently discovered ghrelin.
Aging and age-related diseases--from endocrine therapy to target therapy.
Review
Hu et al., Hangzhou, China. In Mol Cell Endocrinol, 2014
In this regard, the GHRH-GH-IGF-1/Insulin, TOR-S6K1,NAD(+)-Sirtuin, P53, Klotho and APOE pathways have been linked to processes associated with age-related diseases, including cancer, cardiovascular disease, diabetes, osteoporosis, and neurodegenerative diseases, all of which directly influence health in aging, and represent key targets in anti-aging therapy.
Ghrelin: ghrelin as a regulatory Peptide in growth hormone secretion.
Review
Zahiruddin et al., Wardha, India. In J Clin Diagn Res, 2014
OBJECTIVE: This review highlights the interaction of ghrelin with GHRH and somatostatin to regulate the secretion of GH and intends to explore the possible physiological role of the ghrelin-pituitary-GH axis linkage system.
Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances.
Review
Impact
Dattani et al., London, United Kingdom. In Endocr Rev, 2014
With respect to the genetic etiology of isolated GHD (IGHD), mutations in known genes such as those encoding GH (GH1), GHRH receptor (GHRHR), or transcription factors involved in pituitary development, are identified in a relatively small percentage of patients suggesting the involvement of other, yet unidentified, factors.
Profiling of Glucose-Sensing Neurons Reveals that GHRH Neurons Are Activated by Hypoglycemia.
Impact
Friedman et al., New York City, United States. In Cell Metab, 2013
Transcriptional profiling from Gck-cre/EEF1A1-LSL.EGFPL10 mice enriched known and previously unknown glucose-sensing populations including neurons expressing growth hormone releasing hormone (GHRH).
Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats.
GeneRIF
Segev et al., Beersheba, Israel. In Eur Respir J, 2011
We present evidence that growth retardation in upper airway obstruction is associated with a reduction in hypothalamic GHRH content.
Absence of GH-releasing hormone (GHRH) mutations in selected patients with isolated GH deficiency.
GeneRIF
Arnhold et al., São Paulo, Brazil. In J Clin Endocrinol Metab, 2011
GHRH mutations were not identified in a selected cohort of patients with isolated GH deficiency, suggesting that, if they exist, they may be an extremely rare cause of isolated GH deficiency.
Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons.
GeneRIF
Gardette et al., Paris, France. In Eur J Neurosci, 2011
These data suggest that ghrelin increases GHRH neuron excitability by increasing action potential firing rates and decreasing the strength of GABA inputs, leading to enhanced GHRH release; and that obestatin counteracts ghrelin actions.
From GHRH to IGF-1 and downstream: clinical phenotypes and biological mechanisms.
Review
GeneRIF
Klammt et al., Leipzig, Germany. In Pediatr Endocrinol Rev, 2011
The pathomechanisms involved in the genetic defects at both ends of the GHRH-IGF-1 axis.
Cardiovascular actions of the ghrelin gene-derived peptides and growth hormone-releasing hormone.
Review
GeneRIF
Ghigo et al., Torino, Italy. In Exp Biol Med (maywood), 2011
The present paper will give an overview of the main cardiovascular actions of the ghrelin gene-derived peptides and of GHRH.
Tesamorelin.
Impact
Kirkpatrick et al., In Nat Rev Drug Discov, 2011
In November 2010, tesamorelin (Egrifta; Theratechnologies/EMD Serono), a growth hormone-releasing factor analogue, was approved by the US Food and Drug Administration for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy.
Metabolic effects of a growth hormone-releasing factor in patients with HIV.
Impact
Grinspoon et al., Montréal, Canada. In N Engl J Med, 2008
We assessed the use of a growth hormone-releasing factor analogue, tesamorelin, to decrease visceral adiposity.
Development of growth hormone secretagogues.
Review
Impact
Smith, Houston, United States. In Endocr Rev, 2005
I reasoned that GH pulse amplitude could be increased by four possible mechanisms: 1) increasing GHRH release; 2) amplifying GHRH signaling in somatotrophs of the anterior pituitary gland; 3) reducing somatostatin release; and 4) antagonizing somatostatin receptor signaling.
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