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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

G protein-coupled receptor kinase 7

GRK7
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on GRK7
A tale of two kinases in rods and cones.
GeneRIF
Weiss et al., Chapel Hill, United States. In Adv Exp Med Biol, 2011
Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation.
Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.
GeneRIF
Kawamura et al., Ōsaka, Japan. In Photochem Photobiol, 2008
synthesis of 29 of GRK1 or GRK7 partial peptides that cover the entire sequence of GRK1/GRK7, to see which interacts with recoverin.
Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.
GeneRIF
Weiss et al., Chapel Hill, United States. In J Biol Chem, 2005
Phosphorylation of GRK1 and GRK7 by PKA occurs in the dark, when cAMP levels in photoreceptor cells are elevated.
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