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G protein-coupled receptor kinase 7

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: rhodopsin kinase, Rhodopsin, ROD, CAN, ACID
Papers on GRK7
Sensory rewiring in an echolocator: genome-wide modification of retinogenic and auditory genes in the bat Myotis davidii.
Reverter et al., Geelong, Australia. In G3 (bethesda), 2014
Using the naked mole rat as a reference, we found five functional genes (CYP1A2, RBP3, GUCY2F, CRYBB1, and GRK7) encoding visual proteins that have degenerated into pseudogenes in M. davidii but not P. alecto.
Multiple functions of G protein-coupled receptor kinases.
Kurose et al., Fukuoka, Japan. In J Mol Signal, 2013
Subsequent studies revealed that GRK is a family composed of seven isoforms (GRK1-GRK7).
Different phosphorylation rates among vertebrate cone visual pigments with different spectral sensitivities.
Kawamura et al., Suita, Japan. In Biochem Biophys Res Commun, 2013
In this study we compared the rate of light-dependent phosphorylation by GRK7 of carp green- and blue-sensitive cone visual pigments.
A degenerative retinal process in HIV-associated non-infectious retinopathy.
Hardiman et al., San Diego, United States. In Plos One, 2012
Cone-specific transcripts (OPN1SW, OPN1LW, PDE6C, PDE6H and GRK7) are uniformly downregulated in HIV positive retina, likely due to a partial loss of cone photoreceptors.
The origin and evolution of G protein-coupled receptor kinases.
Gurevich et al., Kansas City, United States. In Plos One, 2011
GRKs in Metazoa fall into two clades, one including GRK2 and GRK3, and the other consisting of all remaining GRKs, split into GRK1-GRK7 lineage and GRK4-GRK5-GRK6 lineage in vertebrates.
A tale of two kinases in rods and cones.
Weiss et al., Chapel Hill, United States. In Adv Exp Med Biol, 2011
Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation.
Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses.
Lamb et al., Canberra, Australia. In J Physiol, 2011
To investigate the roles of G-protein receptor kinases (GRKs) in the light responses of vertebrate photoreceptors, we generated transgenic zebrafish lines, the rods of which express either cone GRK (GRK7) or rod GRK (GRK1) in addition to the endogenous GRK1, and we then measured the electrophysiological characteristics of single-cell responses and the behavioural responses of intact animals.
Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onset.
Carraro et al., São Paulo, Brazil. In Cell Death Dis, 2010
The protein expression of CRABP2, IGF2, GRK7, TESK1, HDGF, WNT5B, FZD2 and TIMP3 was characterized in WTs and in a panel of human fetal kidneys displaying remarkable aspects of differentiation, which was recapitulated in the tumor.
Larger inhibition of visual pigment kinase in cones than in rods.
Kawamura et al., Suita, Japan. In J Neurochem, 2010
In the carp retina, visual pigment kinase, GRK1 (G-protein coupled receptor kinase 1) in rods and GRK7 in cones, is inhibited by a photoreceptor neuronal Ca(2+)-sensor protein, S-modulin (or recoverin) in rods and visinin (formerly named s26) in cones.
Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light.
Weiss et al., Chapel Hill, United States. In J Neurochem, 2008
The retina-specific G protein-coupled receptor kinases, GRK1 and GRK7, have been implicated in the shutoff of the photoresponse and adaptation to changing light conditions via rod and cone opsin phosphorylation.
Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.
Kawamura et al., Ōsaka, Japan. In Photochem Photobiol, 2008
synthesis of 29 of GRK1 or GRK7 partial peptides that cover the entire sequence of GRK1/GRK7, to see which interacts with recoverin.
A third photoreceptor-specific GRK found in the retina of Oryzias latipes (Japanese killifish).
Tokunaga et al., Toyonaka, Japan. In Zoolog Sci, 2007
We previously reported that the teleost fish medaka (Oryzias latipes, Japanese killifish), possesses two kinds of G protein-coupled receptor kinases (GRKs) in the retina with different localizations: GRK7 (OlGRK-C) in cones and GRK1 (OlGRK-R1) in rods.
GRK1 and GRK7: unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones.
Fukada et al., Tokyo, Japan. In J Neurochem, 2006
To understand the molecular basis for these characteristics of cone responses, we focused on the opsin deactivation process initiated by G protein-coupled receptor kinase (GRK) 1 and GRK7 in the zebrafish, an animal model suitable for studies on retinal physiology and biochemistry.
Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.
Weiss et al., Chapel Hill, United States. In J Biol Chem, 2005
Phosphorylation of GRK1 and GRK7 by PKA occurs in the dark, when cAMP levels in photoreceptor cells are elevated.
Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation.
Neuhauss et al., Zürich, Switzerland. In Neuron, 2005
In cone-dominant animals as well as in humans, but not in rodents, GRK7, a cone-specific homolog of GRK1, has been identified in cone outer segments.
Highly effective phosphorylation by G protein-coupled receptor kinase 7 of light-activated visual pigment in cones.
Kawamura et al., Suita, Japan. In Proc Natl Acad Sci U S A, 2005
The high GRK7 activity is brought about by high content of a highly potent enzyme.
Isolation and characterization of visual pigment kinase-related genes in carp retina: polyphyly in GRK1 subtypes, GRK1A and 1B.
Kawamura et al., Suita, Japan. In Mol Vis, 2004
We recently showed that the kinase in cones (GRK7) has much higher activity than GRK1 in rods in carp retina.
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