Genome Wide Methylome Alterations in Lung Cancer.
New York City, United States. In Plos One, 2014
IPA analyses showed adenocarcinoma-specific promoter DMxDE overlay identified familiar lung cancer nodes [tP53, Akt] as well as less familiar nodes [HBEGF, NQO1, GRK5, VWF, HPGD, CDH5, CTNNAL1, PTPN13, DACH1, SMAD6, LAMA3, AR].
G protein-coupled receptor kinases in normal and failing myocardium.
Philadelphia, United States. In Front Biosci, 2010
In the heart, the major GRK isoforms, GRK2 and GRK5, undergo upregulation due to the heightened sympathetic nervous system activity that is characteristic of HF as catecholamine levels increase in an effort to drive the failing pump.
GPCR signalling in hypertension: role of GRKs.
Philadelphia, United States. In Clin Sci (lond), 2008
Elevated levels of either GRK2 or GRK5 in both the lymphocytes and VSM (vascular smooth muscle) are associated with human hypertension and animal models of the disease.