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G protein-coupled receptor kinase 5

GRK5, G protein-coupled receptor kinase 5
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GRK2, GRK6, GRK3, GPCR, CAN
Papers on GRK5
GRK5 deficiency leads to susceptibility to intermittent hypoxia-induced cognitive impairment.
New
Suo et al., Kansas City, United States. In Behav Brain Res, Feb 2016
G protein-coupled receptor kinase-5 (GRK5) deficiency is recently found to render subjects more susceptible to cognitive impairment triggered by over-expression of Swedish mutant ß-amyloid precursor protein.
Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
New
Quattrone et al., Catanzaro, Italy. In Psychiatry Res, Jan 2016
In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia.
Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy.
New
Koch et al., Philadelphia, United States. In Circ Res, Jan 2016
GRK5 is highly expressed within myocardium and is upregulated in heart failure.
Role of long purine stretches in controlling the expression of genes associated with neurological disorders.
New
Rajeswari et al., New Delhi, India. In Gene, Dec 2015
Interactome analysis identified four PR-genes in signaling pathways whose dysregulation is correlated directly with pathogenesis: GRK5 and KLK6 in Alzheimer's disease; FGF14 in craniosynostosis, mental retardation and FLT1 in neuroferritinopathy.
β2- and β1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.
New
DʼOcon et al., Valencia, Spain. In J Cardiovasc Pharmacol, Nov 2015
To explore if genic expression of β1- or β2-adrenoceptors (ARs) exhibits a common regulatory pattern with G protein-coupled receptor kinase (GRK) 2, GRK3, or GRK5 expression, we determined messenger RNA levels for these genes in different tissues from human and animal models of cardiovascular disease.
G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro.
New
Grisshammer et al., Rockville, United States. In Biochemistry, Aug 2015
Phosphorylation of NTSR1 by GRK2 was agonist-dependent, whereas phosphorylation by GRK5 occurred in an activation-independent manner.
Different mechanisms of homologous and heterologous μ-opioid receptor phosphorylation.
Review
Schulz et al., Jena, Germany. In Br J Pharmacol, 2015
In fact, morphine induces a selective S375 phosphorylation that is predominantly catalysed by GPCR kinase 5 (GRK5), whereas multisite phosphorylation induced by high-efficacy opioids specifically requires GRK2/3.
GRK5 Polymorphisms and Postoperative Atrial Fibrillation following Coronary Artery Bypass Graft Surgery.
Zhang et al., Laiwu, China. In Sci Rep, 2014
After adjustment for clinical predictors of POAF, two variants in GRK5 gene (rs4752292, and rs11198893) were replicated with significance were replicated in the validation cohort.
Genome Wide Methylome Alterations in Lung Cancer.
Spivack et al., New York City, United States. In Plos One, 2014
IPA analyses showed adenocarcinoma-specific promoter DMxDE overlay identified familiar lung cancer nodes [tP53, Akt] as well as less familiar nodes [HBEGF, NQO1, GRK5, VWF, HPGD, CDH5, CTNNAL1, PTPN13, DACH1, SMAD6, LAMA3, AR].
G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition.
GeneRIF
Benovic et al., Philadelphia, United States. In J Biol Chem, 2012
GRK5 phosphorylates Ser-4 in nucleophosmin and regulates the sensitivity of cells to PLK1 inhibition.
GRK5 deficiency decreases diet-induced obesity and adipogenesis.
GeneRIF
Ma et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
these results suggest that GRK5 is an important regulator of adipogenesis and is crucial for the development of diet-induced obesity.
Involvement of nuclear factor κB (NF-κB) signaling pathway in regulation of cardiac G protein-coupled receptor kinase 5 (GRK5) expression.
GeneRIF
Koch et al., Philadelphia, United States. In J Biol Chem, 2012
NF-kappaB plays a critical role in the regulation of GRK5 transcription in myocytes and that this may translate to the significant expression changes seen in heart disease.
G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression.
GeneRIF
Benovic et al., Philadelphia, United States. In J Biol Chem, 2012
GRK5 is localized in the centrosome and regulates microtubule nucleation and normal cell cycle progression.
Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure.
GeneRIF
Salvador et al., Valencia, Spain. In J Card Fail, 2012
Increased GRK5 expression in the failing myocardium suggests a relevant role in human heart failure.
G protein-coupled receptor kinases in normal and failing myocardium.
Review
Koch et al., Philadelphia, United States. In Front Biosci, 2010
In the heart, the major GRK isoforms, GRK2 and GRK5, undergo upregulation due to the heightened sympathetic nervous system activity that is characteristic of HF as catecholamine levels increase in an effort to drive the failing pump.
Dysfunction of G protein-coupled receptor kinases in Alzheimer's disease.
Review
GeneRIF
Li et al., Kansas City, United States. In Scientificworldjournal, 2009
Studies seem to indicate that mild, soluble, Beta-amyloid accumulation can lead to a reduced membrane (functional) and an elevated cytosolic GRK2/5.
Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure.
Review
Liggett et al., Saint Louis, United States. In Clin Transl Sci, 2008
Prominent among the genes that have been examined so far in heart failure are the beta(1)AR, beta(2)AR, and G-protein-coupled receptor kinase 5 (GRK5).
GPCR signalling in hypertension: role of GRKs.
Review
Eckhart et al., Philadelphia, United States. In Clin Sci (lond), 2008
Elevated levels of either GRK2 or GRK5 in both the lymphocytes and VSM (vascular smooth muscle) are associated with human hypertension and animal models of the disease.
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.
Impact
Dorn et al., Cincinnati, United States. In Nat Med, 2008
Re-sequencing of GRK2 and GRK5 revealed a nonsynonymous polymorphism of GRK5, common in African Americans, in which leucine is substituted for glutamine at position 41.
Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors.
Impact
Malik et al., Chicago, United States. In Nat Med, 2003
We show that the chemokine macrophage inflammatory protein-2 (MIP-2) induces GRK2 and GRK5 expression in PMNs through phosphoinositide-3-kinase (PI3K)-gamma signaling.
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