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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor kinase 4

GRK4, G protein-coupled receptor kinase 4, IT11
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GRK2, GRK5, HAD, GRK6, Angiotensin II
Papers on GRK4
Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition.
New
Jose et al., Zimbabwe. In Hypertension, Feb 2016
G-protein-coupled receptor kinase type 4 (GRK4) is one such gene.
Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.
New
Yang et al., Shenyang, China. In Clin Interv Aging, Dec 2015
The role of GRK4 and DRD1 genes in hypertension remains controversial.
The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum.
New
Bardoni et al., Antibes, France. In Nucleic Acids Res, Oct 2015
We characterized the interaction between FMRP and the mRNA of GRK4, a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase super-family, both in vitro and in vivo.
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
New
Lumb et al., United States. In J Biol Chem, Sep 2015
GRK4 is implicated in the regulation of blood pressure, and three GRK4 polymorphisms (R65L, A142V, and A486V) are associated with hypertension.
α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.
New
Leung et al., Hong Kong, Hong Kong. In Br J Pharmacol, Jul 2015
The mRNA expressions of PKC-α, PKC-ε, PK-N2 and PKC-ζ and of G protein-coupled kinase (GRK)-2, GRK4 and β-arrestin2 were higher in SHR than WKY aortae.
G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).
New
Gurevich et al., Nashville, United States. In J Biol Chem, May 2015
G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in homologous desensitization of GPCRs.
The renal dopaminergic system: novel diagnostic and therapeutic approaches in hypertension and kidney disease.
Review
New
Jose et al., Baltimore, United States. In Transl Res, Apr 2015
Some of these genes encode proteins expressed in the kidney that are needed to excrete a sodium load, for example, dopamine receptors and their regulators, G protein-coupled receptor kinase 4 (GRK4).
Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade.
New
Jose et al., Fukushima, Japan. In Pharmacogenomics J, Apr 2015
UNASSIGNED: Non-synonymous GRK4 variants, R65L, A142V and A486V, are associated with essential hypertension in diverse populations.
The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment.
Review
Ramesar et al., Cape Town, South Africa. In Int J Mol Sci, 2014
GRK4 activity is increased in spontaneously hypertensive rats, and infusion of GRK4 antisense oligonucleotides attenuates the increase in blood pressure (BP).
Gender-based differences on the association between salt-sensitive genes and obesity in Korean children aged between 8 and 9 years.
Park et al., Seoul, South Korea. In Plos One, 2014
GRK4 A486V mutant homozygote was highly distributed in the obese group, but other SNPs had no impact.
Prenatal lipopolysaccharide exposure results in dysfunction of the renal dopamine D1 receptor in offspring.
Zeng et al., China. In Free Radic Biol Med, 2014
In addition, offspring of LPS-treated dams had decreased renal D1R expression, increased D1R phosphorylation, and G protein-coupled receptor kinase type 2 (GRK2) and type 4 (GRK4) protein expression, and impaired D1R-mediated natriuresis and diuresis.
Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.
Atzmon et al., Israel. In Genet Res (camb), 2013
Of these, three missense mutations (rs7426114, rs4073918, rs3752135 in the NEB, SLC6A18 and SIGLEC12 genes, respectively) and three synonymous mutations (rs2071856, rs2515941, rs716745 in the ELFN2, GRK4, LRRC55 genes) displayed significant different rates in SF cases compared with controls.
G protein-coupled receptor accessory proteins and signaling: pharmacogenomic insights.
Review
Chidiac et al., Toronto, Canada. In Methods Mol Biol, 2013
These include the contribution of variants of the regulator of G protein signaling (RGS) protein to hypertension; the role variants of the activator of G protein signaling (AGS) proteins to phenotypes (such as the type III AGS8 variant to hypoxia); the contribution of G protein-coupled receptor kinase (GRK) proteins, such as GRK4, in disorders such as hypertension.
Functions of third extracellular loop and helix 8 of Family B GPCRs complexed with RAMPs and characteristics of their receptor trafficking.
Review
Kato et al., Miyazaki, Japan. In Curr Protein Pept Sci, 2013
In addition, we demonstrated that overexpression of GPCR kinase (GRK) 2, GRK3 and GRK4 enhances the AM-induced internalization of the CLR/RAMP2 heterodimer.
G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension.
GeneRIF
Charlton et al., Cape Town, South Africa. In J Hum Hypertens, 2012
GRK-4 polymorphisms predict blood pressure response to dietary modification in Black subjects with mild-to-moderate hypertension.
Dopamine, the kidney, and hypertension.
Review
Zhang et al., Nashville, United States. In Curr Hypertens Rep, 2012
In addition, studies in both experimental animal models and in humans with salt-sensitive hypertension implicate abnormalities in dopamine receptor regulation due to receptor desensitization resulting from increased G-protein receptor kinase 4 (GRK4) activity.
Pooled analyses of the associations of polymorphisms in the GRK4 and EMILIN1 genes with hypertension risk.
GeneRIF
Xi et al., Taizhou, China. In Int J Med Sci, 2011
The significant association was also found for rs2960306 polymorphism in the GRK4 gene among Europeans.
Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation.
Review
GeneRIF
Felder et al., Washington, D.C., United States. In Biochim Biophys Acta, 2010
Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation.
G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.
GeneRIF
Zhang et al., Beijing, China. In Hypertens Res, 2010
The G-protein-coupled receptor kinase 4 (T-rs1024323-C and T-rs1801058-C) polymorphisms were not associated with a risk of preeclampsia in Northern Han Chinese.
G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor.
GeneRIF
Jose et al., Quezon, Philippines. In J Biol Chem, 2009
GRK4, specifically the GRK4-gamma and GRK4-alpha isoforms, phosphorylates the D(3) receptor and is crucial for its signaling in human proximal tubule cells
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