Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.
Israel. In Genet Res (camb), 2013
Of these, three missense mutations (rs7426114, rs4073918, rs3752135 in the NEB, SLC6A18 and SIGLEC12 genes, respectively) and three synonymous mutations (rs2071856, rs2515941, rs716745 in the ELFN2, GRK4, LRRC55 genes) displayed significant different rates in SF cases compared with controls.
G protein-coupled receptor accessory proteins and signaling: pharmacogenomic insights.
Toronto, Canada. In Methods Mol Biol, 2013
These include the contribution of variants of the regulator of G protein signaling (RGS) protein to hypertension; the role variants of the activator of G protein signaling (AGS) proteins to phenotypes (such as the type III AGS8 variant to hypoxia); the contribution of G protein-coupled receptor kinase (GRK) proteins, such as GRK4, in disorders such as hypertension.
Dopamine, the kidney, and hypertension.
Nashville, United States. In Curr Hypertens Rep, 2012
In addition, studies in both experimental animal models and in humans with salt-sensitive hypertension implicate abnormalities in dopamine receptor regulation due to receptor desensitization resulting from increased G-protein receptor kinase 4 (GRK4) activity.