GRK3 is essential for metastatic cells and promotes prostate tumor progression.
Houston, United States. In Proc Natl Acad Sci U S A, 2014
We discovered that G-protein-coupled receptor kinase 3 (GRK3; or β-adrenergic receptor kinase 2) was not only necessary for survival and proliferation of metastatic cells, but also sufficient to promote primary prostate tumor growth and metastasis upon exogenous expression in poorly metastatic cells in mouse xenograft models.
Genetics of bipolar disorder.
Wako, Japan. In Drugs Today (barc), 2005
Among recently reported candidate genes, BDNF, G72, AKT1, GRIN2A, XBP1, GRK3, HTR4, IMPA2 and GABRA1 may have some importance.
Non-visual GRKs: are we seeing the whole picture?
Leicester, United Kingdom. In Trends Pharmacol Sci, 2003
Studies of the details and consequences of these mechanisms have focused heavily on the original beta-adrenoceptor kinase (beta-ARK) family (GRK2 and GRK3) and, in particular, on phosphorylation-dependent recruitment of adaptor proteins such as the beta-arrestins.