Protein kinase signaling in the modulation of microvascular permeability
In The Journal of Experimental Medicine, 2001
... Anti-FAK, anti–phospho FAK PY576, anti-RhoA, anti-RACK1, anti-Gβ1, anti-Fyn, anti-cSrc, anti-VE-cadherin, anti-GRK2, anti-GFP, anti-p120, anti-phosphotyrosine Abs (PY20, PY99, and PY350), and protein A/G agarose beads were purchased from Santa Cruz Biotechnology, Inc ...
Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.
Madrid, Spain. In Arch Physiol Biochem, Dec 2015
In particular, we focus on the importance of studying the integrated regulation of different organs and pathways that contribute to the global pathophysiology of this condition with a specific emphasis on the role of emerging key molecular nodes such as the G protein-coupled receptor kinase 2 (GRK2) signalling hub.
RKIP: a governor of intracellular signaling.
Würzburg, Germany. In Crit Rev Oncog, 2013
In this work, we will review mechanistic details of the regulation of RKIP as inhibitor of Raf-1 and G protein-coupled receptor kinase 2 (GRK2) that enable RKIP to coordinate the cell's balance between inhibition and potentiation of mitogenic ERK1/2 signaling--a prominent example of RKIP's function as a regulator of intracellular signaling.
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.
Chicago, United States. In Nat Immunol, 2012
The extracellular signal-regulated kinase Erk potentiated activity of the G protein-coupled receptor kinase GRK2 and inhibited neutrophil migration, whereas the MAPK p38 acted as a noncanonical GRK that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil migration by blocking GRK2 function.