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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Adrenergic, beta, receptor kinase 1

GRK2, beta-adrenergic receptor kinase, betaARK1
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using GRK2 antibodies
EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation
Hess Sonja, In PLoS ONE, 2007
... Rabbit anti-DDB2 antibody, rabbit anti-GRK2 antibody, and protein A/G agarose were from Santa Cruz Biotechnology.
Protein kinase signaling in the modulation of microvascular permeability
Mehta Dolly et al., In The Journal of Experimental Medicine, 2001
... Anti-FAK, anti–phospho FAK PY576, anti-RhoA, anti-RACK1, anti-Gβ1, anti-Fyn, anti-cSrc, anti-VE-cadherin, anti-GRK2, anti-GFP, anti-p120, anti-phosphotyrosine Abs (PY20, PY99, and PY350), and protein A/G agarose beads were purchased from Santa Cruz Biotechnology, Inc ...
Papers on GRK2
Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation.
Caron et al., Durham, United States. In J Neurosci, 2012
This study demonstrated that the elimination of GRK2 in cholinergic neurons reduces sensitivity to select muscarinic-mediated behaviors
GRK2 contribution to the regulation of energy expenditure and brown fat function.
Fernández-Veledo et al., Madrid, Spain. In Faseb J, 2012
hemizygous mice displayed better thermogenic capacity and exhibited more oxidative phenotype in both BAT and WAT than WT littermates. Overexpression of GRK2 in brown adipocytes corroborated the negative effect in BAT function and differentiation
Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.
Lorenz et al., Würzburg, Germany. In J Biol Chem, 2012
Data show that a dimeric Raf kinase inhibitor protein (RKIP) mutant displayed a higher affinity to G protein-coupled receptor kinase (GRK) 2, but a lower affinity to Raf1.
Inhibitor of G protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction.
Kobayashi et al., Tokyo, Japan. In Endocrinology, 2012
G protein-coupled receptor kinase 2 inhibitor normalizes vascular endothelial function in type 2 diabetic mice by improving beta-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction
Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility.
Mayor et al., Madrid, Spain. In Sci Signal, 2011
GRK2-HDAC6 functional interaction may have important implications in pathological contexts related to epithelial cell migration
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