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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Growth factor receptor-bound protein 7

GRB7, B47
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: erbB-2, Src, CAN, Insulin, Grb2
Papers on GRB7
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
Kiessling et al., Athens, Greece. In Stem Cells Dev, Feb 2016
High-level detection of CSF1R, ENG, IL23R, and IL3RA specifically on the 8C arrays suggests the embryo plays an active role in blocking immune rejection and is poised for trophectoderm development; robust detection of NRG1, GAB1, -2, GRB7, and FGF14(FHF4) indicates novel roles in early development in addition to their known roles in later development.
High-level recombinant protein production by the basidiomycetous yeast Pseudozyma antarctica under a xylose-inducible xylanase promoter.
Kitamoto et al., Tsukuba, Japan. In Appl Microbiol Biotechnol, Jan 2016
Biodegradable plastic (BP)-degrading enzymes of P. antarctica JCM10317 (PaE) and Paraphoma-related fungal strain B47-9 (PCLE) were used as reporter proteins and inserted into pPAX1-neo, resulting in pPAX1-neo::PaCLE1 and pPAX1-neo::PCLE, respectively.
Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma that are Preferentially Associated with Wild Type RAS/RAF.
Ladanyi et al., Kettering, United States. In Mol Cancer Res, Jan 2016
Three RTK fusions were identified: NCOA4-RET, ERBB2-GRB7, ETV6-NTRK3.
Water management, rice varieties and mycorrhizal inoculation influence arsenic concentration and speciation in rice grains.
Chen et al., Beijing, China. In Mycorrhiza, Dec 2015
UNASSIGNED: A pot experiment was carried out to investigate the effects of water management and mycorrhizal inoculation on arsenic (As) uptake by two rice varieties, the As-resistant BRRI dhan 47 (B47) and As-sensitive BRRI dhan 29 (B29).
Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.
Geahlen et al., West Lafayette, United States. In J Biol Chem, Dec 2015
Grb7 is identified as a Syk-binding protein involved in the recruitment of Syk to the stress granule.
Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
Wilce et al., Sydney, Australia. In J Med Chem, Nov 2015
The Grb7 adaptor protein is a therapeutic target for both TNBC and HER2+ breast cancer.
Non-HER2 signaling pathways activated in resistance to anti-HER2 therapy in breast cancer.
Calleja-Hernández et al., Granada, Spain. In Breast Cancer Res Treat, Oct 2015
GRB7, included in the 17q12 amplicon, has been associated to poor prognosis in BC patients.
Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility.
Almer et al., Jönköping, Sweden. In Biomed Res Int, 2014
Inflammation resulted in the reduced colonic expression of ERBB2, GRB7, MIEN1, and PGAP3 (P = 1.0 × 10(-4)-1.0
An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma.
Mimori et al., Beppu, Japan. In Plos One, 2014
Analysis of survival data and RNAi screening data suggested that GRB7, located on 17q12, was a driver gene in ESCC.
Grb7 gene amplification and protein expression by FISH and IHC in ovarian cancer.
Yu et al., Chongqing, China. In Int J Clin Exp Pathol, 2014
OBJECTIVE: Overexpression of growth factor receptor-bound protein 7 (Grb7) has been found in numerous human cancers.
Targeting SH2 domains in breast cancer.
McMurray et al., Houston, United States. In Future Med Chem, 2013
Herein we review phosphopeptide mimetic and small-molecule approaches targeting the SH2 domains of Grb2, Grb7 and STAT3 that inhibit their targets and reduce proliferation in in vitro breast cancer models.
Grb10 is a dual regulator of receptor tyrosine kinase signaling.
Kazi et al., Barisāl, Bangladesh. In Mol Biol Rep, 2013
The adaptor protein Grb10 is a close homolog of Grb7 and Grb14.
The HER2 amplicon in breast cancer: Topoisomerase IIA and beyond.
Lamy et al., Montpellier, France. In Biochim Biophys Acta, 2013
In addition it will discuss the clinical and biological implications of the amplification of ten other genes at this locus (MED1, STARD3, GRB7, THRA, RARA, IGFPB4, CCR7, KRT20, KRT19 and GAST) in breast cancer.
Targeting the calmodulin-regulated ErbB/Grb7 signaling axis in cancer therapy.
Jellali et al., Madrid, Spain. In J Pharm Pharm Sci, 2012
In this short review we will describe the regulation exerted by the calcium-receptor protein calmodulin (CaM) on signaling routes involving the family of ErbB receptors - highlighting the epidermal growth factor receptor (EGFR/ErbB1) and ErbB2 - and the adaptor protein Grb7, a downstream signaling component of these receptors.
Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene.
Watanabe et al., Tokyo, Japan. In Febs Lett, 2012
GRB7 is a context-dependent oncogene, which modulates the ERBB2 signaling pathway through enhanced phosphorylation of ERBB2 and Akt.
Calmodulin regulates the translocation of Grb7 into the nucleus.
Villalobo et al., Madrid, Spain. In Febs Lett, 2012
propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS
Novel nonphosphorylated peptides with conserved sequences selectively bind to Grb7 SH2 domain with affinity comparable to its phosphorylated ligand.
Gao et al., Beijing, China. In Plos One, 2011
A series of Grb7 SH2 domain-binding nonphosphorylated peptides in the yeast two-hybrid system, were identified.
Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation.
Lyons et al., Las Cruces, United States. In J Mol Recognit, 2011
Full-length Grb7 and Hax-1 interact in mammalian cells and Grb7 is tyrosine phosphorylated.
Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide.
Wilce et al., Australia. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
X-ray diffraction data were collected from crystals to 2.4A resolution for G7-18NATE in complex with its Grb7 SH2 domain.
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
Dorssers et al., Rotterdam, Netherlands. In J Clin Oncol, 2009
PATIENTS AND METHODS: mRNA levels of 10 BCAR genes (AKT1, AKT2, BCAR1, BCAR3, EGFR, ERBB2, GRB7, SRC, TLE3, and TRERF1) were measured in estrogen receptor-positive breast tumors using quantitative reverse-transcriptase polymerase chain reaction.
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