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Growth factor receptor-bound protein 2

Grb2, Mash1
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HSP60, Src, V1a, ERK
Papers using Grb2 antibodies
A two-step model for colon adenoma initiation and progression caused by APC loss.
Hansen Immo A., In PLoS ONE, 2008
... Anti Grb2 was from Cell Signaling, and anti-dvl2 was from ...
Evidence that MIG-6 is a tumor-suppressor gene
Segatto Oreste et al., In The Journal of Cell Biology, 2006
... polyclonal anti-EGFR and anti–c-Myc antibodies, goat polyclonal antibody to EEA1, and mAb P4D1 anti-Ub and anti-GRB2 were purchased from Santa Cruz Biotechnology, Inc ...
β4 integrin activates a Shp2–Src signaling pathway that sustains HGF-induced anchorage-independent growth
Trusolino Livio et al., In The Journal of Cell Biology, 2003
... We used the following reagents: anti–human Met, anti-Shp2, anti-Src, antiactin, GST-Shp2, and GST-SH2-Grb2 (Santa Cruz Biotechnology, Inc.); anti-β4 integrin (BD ...
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Shemanko Carrie S et al., In Breast Cancer Research : BCR, 2002
... Mouse anti-phospho-histone 2A.X (Ser139) clone JBW301 and anti-GRB2 antibodies (Upstate, Charlottesville, USA) and mouse anti-GRB2 (BD Biosciences, Ontario, Canada) were also ...
Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.
Harris William A., In PLoS Biology, 2000
... Mash1 heterozygous mice were also crossed with a transgenic mouse line expressing GFP ...
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Papers on Grb2
Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.
Van Etten et al., Toronto, Canada. In Blood, Feb 2016
BCR-ABL1, via phosphorylated Tyr177, recruits the adapter GAB2 as part of a GRB2/GAB2 complex.
Genomic characterization of primary central nervous system lymphoma.
Mano et al., Tokyo, Japan. In Acta Neuropathol, Feb 2016
Oncogenic mutations in GRB2 were also detected, the effects of which in cultured cells were attenuated by inhibitors of the downstream kinases MAP2K1 and MAP2K2.
Recurrent activating mutations of CD28 in peripheral T-cell lymphomas.
Chan et al., Xi'an, China. In Leukemia, Jan 2016
Surface plasmon resonance analysis of mutations at these residues with predicted differential partner interactions showed increased affinity for ligand CD86 (residue D124) and increased affinity for intracellular adaptor proteins GRB2 and GADS/GRAP2 (residue T195).
Triple SILAC quantitative proteomic analysis reveals differential abundance of cell signaling proteins between normal and lung cancer-derived exosomes.
Mao et al., Baltimore, United States. In J Proteomics, Jan 2016
Proteins associated with signal transduction, including EGFR, GRB2 and SRC, were enriched in NSCLC exosomes, and could actively regulate cell proliferation in recipient cells.
Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression.
Cheung et al., Charleston, United States. In Oncogene, Jan 2016
UNASSIGNED: We previously found that the scaffold adapter GRB2-associated binding protein 2 (GAB2) is amplified and overexpressed in a subset of primary high-grade serous ovarian cancers and cell lines.
Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage.
Qian et al., Shanghai, China. In Immunity, Oct 2015
Act1, an essential adaptor in IL-17 signaling, suppressed FGF2-induced ERK activation through binding to adaptor molecule GRB2 to interfere with its association with guanine nucleotide exchange factor SOS1. Act1 preferentially bound to IL-17 receptor complex, releasing its suppressive effect on FGF2 signaling.
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells.
Mraz et al., Brno, Czech Republic. In Eur J Haematol, Mar 2015
In lymphoma B cells, the balance of initiation, amplitude and duration of BCR activation can be influenced by a specific immunoglobulin structure, the expression and mutations of adaptor molecules (like GAB1, BLNK, GRB2, CARD11), the activity of kinases (like LYN, SYK, PI3K) or phosphatases (like SHIP-1, SHP-1 and PTEN) and levels of microRNAs.
Resolved and open issues in chromaffin cell development.
Kalcheim et al., Freiburg, Germany. In Mech Dev, 2013
MASH1 and Phox2B, have similar, but also distinct functions in chromaffin and sympathetic neuronal development, and BMP-4 not only induces sympathoadrenal (SA) cells at the dorsal aorta and within the adrenal gland, but also promotes chromaffin cell maturation.
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis.
Tomes et al., Mendoza, Argentina. In Proc Natl Acad Sci U S A, 2012
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis, and Rab27 is also required for the acrosome reaction.
The dynamic expression of Mash1 in the hippocampal subgranular zone after fimbria-fornix transection.
Jin et al., Nantong, China. In Neurosci Lett, 2012
after FF transection, Mash1 expression in the deafferented hippocampus increased and might play an important role in inducing local progenitors to differentiate into neurons.
Inhibition of basal FGF receptor signaling by dimeric Grb2.
Ladbury et al., Houston, United States. In Cell, 2012
Study describes a mechanism whereby Grb2 exerts control of FGFR2 kinase activity prior to growth factor binding.
Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.
Farooq et al., Miami, United States. In Febs J, 2012
Data show that bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.
A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy.
Gabellini et al., Milano, Italy. In Cell, 2012
Long Non-coding RNA, DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription.
Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer.
Golemis et al., Philadelphia, United States. In Drug Resist Updat, 2011
Moving downstream, we discuss critical EGFR-dependent effectors, including PLC-γ; PI3K and PTEN; SHC, GRB2, and RAS and the STAT proteins, as factors in resistance to EGFR-directed inhibitors and as alternative targets of therapeutic inhibition.
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.
Pawson et al., Toronto, Canada. In Nat Biotechnol, 2011
Our data reliably define context-specific and time-dependent networks that form around GRB2 after stimulation, and reveal core and growth factor-selective complexes comprising 90 proteins identified as interacting with GRB2 in HEK293T cells.
Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis.
Terskikh et al., Los Angeles, United States. In Cell Stem Cell, 2011
We found that SOX2 binds directly to NGN1 and MASH1 promoters and is required for their expression.
Genome-wide association studies in Alzheimer's disease.
Tanzi et al., Berlin, Germany. In Hum Mol Genet, 2009
On the basis of the data available at the time of this writing, the most compelling novel GWAS signal has been observed in GAB2 (GRB2-associated binding protein 2), followed by less consistently replicated signals in galanin-like peptide (GALP), piggyBac transposable element derived 1 (PGBD1), tyrosine kinase, non-receptor 1 (TNK1).
The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility.
Way et al., London, United Kingdom. In Nature, 2009
Taking advantage of this, we have analysed the dynamics of neuronal Wiskott-Aldrich syndrome protein (N-WASP), WASP-interacting protein (WIP), GRB2 and NCK, which are required to stimulate actin-related protein (ARP)2/3-complex-dependent actin-based motility of vaccinia virus, using fluorescence recovery after photobleaching.
Small cell lung cancer: significance of RB alterations and TTF-1 expression in its carcinogenesis, phenotype, and biology.
Shimoyamada et al., Yokohama, Japan. In Endocr Pathol, 2008
SCLC cells almost always express mammalian achaete-scute homolog-1 (MASH1) and thyroid transcription factor-1 (TTF-1).
A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus.
Natesan et al., Rochester, United States. In Cell Stem Cell, 2008
In a recent paper in Nature Neuroscience, Jessberger et al. (2008) report that overexpression of ASCL1 (mash1) directs adult hippocampal progenitors to adopt an oligodendrocytic fate.
More papers using Grb2 antibodies
Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes
Yang Jun et al., In Molecular Cancer, 1998
... purchased from Chemicon Intl; anti-Flt-1 (sc-316), anti-KDR (sc-6251), anti-Kinesin heavy chain (sc-13359), anti-Stanniocalcin (sc-14352), and anti-Grb2 were obtained from Santa Cruz Biotechnology Inc., and anti-β ...
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis
Huynh-Do Uyen et al., In The Journal of Cell Biology, 1997
... The following antibodies were used for immunoprecipitation: rabbit anti-Grb2 (Santa Cruz Biotechnology, Inc.) and rabbit anti-Shc ...
Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats.
Sesti Giorgio, In PLoS ONE, 1997
... anti-Bcl-x (BD Biosciences), rabbit anti-ERK, anti-JNK, anti-Cleaved caspase-3, anti-Bcl-10 (Cell Signaling), rabbit anti-Caspase-1- and mouse anti-GRB2- (Abcam Cambridge, UK) antibodies ...
Regulation of ceramide production and apoptosis
Oess Stefanie et al., In The Journal of Experimental Medicine, 1997
... tail of (cyt)TNFR-I with full-length Grb2 and the SH3 or SH2 domain– mutated forms of Grb2, the matchmarker two-hybrid system was instrumental (Clontech ...
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