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GRB2-related adaptor protein

Grap, Grb2-related adaptor protein
This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Grb2, ACID, GRID, Src, LAT
Papers on Grap
A helix-coil transition induced by the metal ion interaction with a grafted iron-binding site of the CyaY protein family.
New
Santos et al., Junín, Argentina. In Dalton Trans, Mar 2015
The resulting grafted peptide named GRAP was studied by applying experimental (circular dichroism, isothermal titration calorimetry, capillary zone electrophoresis, thermal denaturation, NMR) and computational approaches (docking, molecular dynamics simulations).
GraP: platform for functional genomics analysis of Gossypium raimondii.
Su et al., Beijing, China. In Database (oxford), 2014
A comprehensive database, Platform of Functional Genomics Analysis in Gossypium raimondii (GraP), was constructed to provide multi-dimensional analysis, integration and visualization tools.
Defining critical residues for substrate binding to 1-deoxy-D-xylulose 5-phosphate synthase--active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate.
Freel Meyers et al., Baltimore, United States. In Febs J, 2014
1-Deoxy-D-xylulose 5-phosphate (DXP) synthase catalyzes the formation of DXP from pyruvate and D-glyceraldehyde 3-phosphate (GraP) in a thiamin diphosphate-dependent manner, and is the first step in the essential pathway to isoprenoids in human pathogens.
Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes.
Witkowski et al., Gdańsk, Poland. In Immunology, 2011
We show here that genes encoding one of the zinc finger proteins (ZNF334), the 'aging hormone' Klotho, the retinoid acid receptor β2 (RARβ2) and the T-cell adapter protein GRAP-2, contain sequences with various (exceeding 70%) degrees of homology to the 'α' sequence near their promoters.
Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.
GeneRIF
Powell et al., Louisville, United States. In Biochim Biophys Acta, 2010
Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from diabetic mice, indicating a potential novel role for GRAP in TGF-beta-induced tubule injury in diabetic kidney disease.
Effect of (211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes.
Schneeweiss et al., Jülich, Germany. In Int J Radiat Biol, 2009
METHOD: BBC3 (B-cell lymphoma 2 binding component 3), CD69 (cluster of differentiation 69), CDKN1A (cyclin-dependent kinase inhibitor 1A), DUSP8 (dual specificity phosphatase 8) EGR1 (early growth response 1), EGR4 (early growth response 4), GADD45A (growth arrest and DNA-damage-inducible, alpha), GRAP (growth factor receptor-bound protein 2-related adaptor protein), LAP1B (TOR1AIP1; torsin A interacting protein 1), IFNG (interferon gamma), ISG20L1 (interferon-stimulated exonuclease gene 20kDa - like 1), c-JUN (jun oncogene), MDM2 (mouse double minute 2), PCNA (proliferating cell nuclear antigen), PLK2 (polo-like kinase 2), RND1 (rho family GTPase 1), TNFSF9 (tumour necrosis factor superfamily member 9) and TRAF4 (tumour necrosis factor receptor-associated factor 4). RESULTS: The expressions of the 18 genes, except GRAP, were up-regulated following exposure to alpha-radiation.
Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma.
Karges et al., München, Germany. In Cancer Lett, 2009
We have previously identified the adaptor Grap-2 as RET binding protein.
Surface plasmon resonance biosensor detects the downstream events of active PKCbeta in antigen-stimulated mast cells.
Hide et al., Hiroshima, Japan. In Biosens Bioelectron, 2008
In this study, we investigated the relationship between intracellular signaling events induced by antigen and the change of AR, by genetic manipulation of intracellular signaling molecules; spleen tyrosine kinase (Syk), src-like adaptor protein (SLAP), linker for activation of T cells (LAT), growth-factor-receptor-bound protein 2 (Grb2), Grb2-related adaptor protein (Gads), and isotypes of protein kinase C (PKC).
CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.
GeneRIF
Rudd et al., Cambridge, United Kingdom. In Biochem Biophys Res Commun, 2008
Our findings define a pathway involving CD28 binding to Grb-2 and its co-operativity with Vav1 in the regulation of T-cell co-stimulation.
Structural features of the full-length adaptor protein GADS in solution determined using small-angle X-ray scattering.
Dimasi et al., Genova, Italy. In Biophys J, 2008
The Grb2-related adaptor protein GADS plays a central role during the initial phases of signal transduction in T lymphocytes.
Mapping of signaling pathways by functional interaction proteomics.
Kolch et al., Glasgow, United Kingdom. In Methods Mol Biol, 2007
The second is the differential analysis of binding partners of the C-terminal SH3 domain of the two small adaptor proteins Grb2 and GRAP.
Search on chromosome 17 centromere reveals TNFRSF13B as a susceptibility gene for intracranial aneurysm: a preliminary study.
Koizumi et al., Kyoto, Japan. In Circulation, 2006
METHODS AND RESULTS: Nine genes (TNFRSF13B, M-RIP, COPS3, RAI1, SREBF1, GRAP, MAPK7, MFAP4, and AKAP10) were selected from 108 genes that are located between D17S1857 and D17S1871 by excluding 99 genes that were pseudogenes, hypothetical genes, or well-characterized genes but not likely associated with IA.
Functional interactions of HPK1 with adaptor proteins.
Review
Tan et al., Houston, United States. In J Cell Biochem, 2005
The HPK1 association with Crk, CrkL, and HIP-55 mediate HPK1-dependent c-Jun N-terminal kinase (JNK) activation, while the association of HPK1 with SLP-76, Gads, CrkL, Grb2, and Grap affect T- and B-cell dependent gene transcription.
Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.
GeneRIF
Daëron et al., Paris, France. In J Biol Chem, 2005
FcgammaRIIB docking site for the SH2 domain-containing adapters Grb2 and Grap
Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.
GeneRIF
Sawada et al., Nerima, Japan. In J Int Med Res, 2004
Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome.
Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.
GeneRIF
Feng et al., Los Angeles, United States. In Mol Cell Biol, 2002
Data suggest that Grap, unlike Grb2, acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk pathway.
LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways.
Review
Wange, Baltimore, United States. In Sci Stke, 2001
Phosphorylation of LAT creates binding sites for the Src homology 2 (SH2) domains of other proteins, including PLC-gamma1, Grb2, Gads, Grap, 3BP2, and Shb, and indirectly binds SOS, c-Cbl, Vav, SLP-76, and Itk.
HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.
Impact
Weiss et al., San Francisco, United States. In Immunity, 2000
Subsequent analysis revealed that Src and Syk/ZAP-70 tyrosine kinases and the adaptor proteins LAT, SLP-76, BLNK, Grb2, and Grap are involved in HPK1 activation.
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