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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Granzyme H

granzyme H, CGL-2, GzmH
Top mentioned proteins: HAD, CAN, ACID, galectin-1, Insulin
Papers on granzyme H
Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ.
New
Chen et al., Nanjing, China. In Dis Model Mech, Jan 2016
The seipin gene (BSCL2) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2).
Congenital generalized lipodystrophy: identification of novel variants and expansion of clinical spectrum.
New
Hilbert et al., Boston, United States. In Clin Genet, Jul 2015
Some manifestations were exclusively noticed in our CGL2 patients; hypertrichosis, high-pitched voice and umbilical hernia.
Upregulation of glycans containing 3' fucose in a subset of pancreatic cancers uncovered using fusion-tagged lectins.
New
Haab et al., Grand Rapids, United States. In J Proteome Res, Jul 2015
We used a database of glycan array data to identify the lectins CCL2 to detect glycan motifs with fucose in a 3' linkage; CGL2 for motifs with fucose in a 2' linkage; and RSL for fucose in all linkages.
Inhibition of Haemonchus contortus larval development by fungal lectins.
Štefanić et al., Zürich, Switzerland. In Parasit Vectors, 2014
METHODS: The effect of Coprinopsis cinerea lectins - CCL2, CGL2, CGL3; Aleuria aurantia lectin - AAL; Marasmius oreades agglutinin - MOA; and Laccaria bicolor lectin - Lb-Tec2, on cultivated Haemonchus contortus larval stages was investigated using a larval development test (LDT).
Granzyme h serum levels variations with both reproductive hormone receptors, and related hormone receptors in breast cancer patients.
Jahani et al., Tehrān, Iran. In Iran J Cancer Prev, 2013
Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system.
Granzyme H is a novel protease expressed by human mast cells.
Pejler et al., Uppsala, Sweden. In Int Arch Allergy Immunol, 2013
Here, we address the human relevance of the latter findings by investigating whether human mast cells express granzyme H, the granzyme that may represent the functional counterpart to murine granzyme D. METHODS: Cord blood-derived mast cells, LAD2 cells and skin mast cells in situ were evaluated for their expression of granzymes using quantitative PCR, Western blot analysis and immunostaining.
Conservation of the extended substrate specificity profiles among homologous granzymes across species.
Van Damme et al., Gent, Belgium. In Mol Cell Proteomics, 2013
To date four out of five human granzymes have assigned orthologs in mice; however for granzyme H, no murine ortholog has been suggested and its role in cytotoxicity remains controversial.
Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation.
Bleackley et al., Edmonton, Canada. In Mol Immunol, 2013
Natural killer and T cell-mediated cytotoxicity is important for the elimination of viruses and transformed cells.
Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus.
Han et al., Singapore, Singapore. In Biochem J, 2013
Homozygous mutations in BSCL2 (Berardinelli-Seip congenital lipodystrophy)/seipin cause CGL2 (congenital generalized lipodystrophy type 2).
Molecular underpinning of extranodal NK/T-cell lymphoma.
Review
Gaulard et al., Taiwan. In Best Pract Res Clin Haematol, 2013
Gene expression profiling identified that most of the NKTCL are derived from activated natural killer cells with distinctively high expression of granzyme H compared to other PTCLs, which might serve as a new diagnostic biomarker.
Identification of SERPINB1 as a physiological inhibitor of human granzyme H.
Fan et al., Beijing, China. In J Immunol, 2013
Granzyme H (GzmH) is constitutively expressed in NK cells and induces target cell death; however, how GzmH activity is regulated remains elusive.
Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein.
GeneRIF
Fan et al., Beijing, China. In J Immunol, 2012
GzmH suppresses viral replication through association with the hepatitis B virus x protein.
Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif.
GeneRIF
Fan et al., Beijing, China. In J Immunol, 2012
An unusual RKR motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites.
A Patient with Congenital Generalized Lipodystrophy Due To a Novel Mutation in BSCL2: Indications for Secondary Mitochondrial Dysfunction.
Kalkhoven et al., Utrecht, Netherlands. In Jimd Rep, 2011
BACKGROUND: Congenital generalized lipodystrophy (CGL) results from mutations in AGPAT2, encoding 1-acyl-glycerol-3-phosphate-acyltransferase 2 (CGL1; MIM 608594), BSCL2, encoding seipin (CGL2; MIM 269700), CAV1, encoding caveolin1 (CGL3; MIM 612526) or PTRF, encoding polymerase I and transcript release factor (CGL4; MIM 613327).
Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity.
GeneRIF
Andrade et al., Mexico. In Cell Death Differ, 2009
Cleavage of La protein by granzyme H generates a COOH-terminal truncated form of La protein that loses nuclear localization and decreases hepatitis C virus-internal ribosome entry site-mediated translational activity.
Seipinopathy: a novel endoplasmic reticulum stress-associated disease.
Review
Suzuki et al., Tokyo, Japan. In Brain, 2009
The Seipin/BSCL2 gene was originally identified as a loss-of-function gene for congenital generalized lipodystrophy type 2 (CGL2), a condition characterized by severe lipoatrophy, insulin resistance, hypertriglyceridaemia and mental retardation.
Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage.
GeneRIF
Fan et al., Beijing, China. In Mol Immunol, 2008
GzmH may play an essential role in caspase-dependent pathogen clearance in the innate immunity that may complement the proapoptotic function of GzmB in human NK cells.
H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells.
Review
GeneRIF
Trapani et al., Melbourne, Australia. In Trends Immunol, 2007
Granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B.
[Seipin/BSCL2-related motor neuron disease: Seipinopathy is a novel conformational disease associated with endoplasmic reticulum stress].
Review
Suzuki et al., In Rinsho Shinkeigaku, 2007
The Seipin/BSCL2 gene was originally identified as a candidate gene for congenital generalized lipodystrophy type 2 (CGL2) (OMIM #269700).
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