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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Granzyme B

granzyme B, gzmB
Top mentioned proteins: CD8, Perforin, CD4, CAN, HAD
Papers using granzyme B antibodies
Extracellular matrix remodeling of lung alveolar walls in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence
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Granville D J et al., In Cell Death & Disease, 2009
... Murine GZMB enzymatic activity assayIncreasing serpin concentrations (0.625–80 nM) were pre-incubated with active recombinant mGZMB (20 nM, Sigma Aldrich, St ...
Cytotoxic T-cell non-Hodgkin's lymphoma of the thyroid gland
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Lee Young-Don et al., In Journal of Korean Medical Science, 2004
... CD20 (Dako, prediluted), CD4 (Dako, prediluted), CD8 (Dako, prediluted), T-cell-restricted intracellular antigen-1 (TIA-1, Dako, prediluted), granzyme B (Dako, prediluted), βF-1 (Dako, prediluted) ...
Aberrant T-cell receptor signaling of interferon-gamma- and tumor necrosis factor-alfa-producing cytotoxic CD8+ Vdelta1/Vbeta16 T cells in a patient with chronic neutropenia
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Maryniak Renata et al., In Arthritis Research & Therapy, 2002
... CD3, myeloperoxydase, hemoglobin (polyclonal), CD20 (L26), CD8 (C8/144B) (DAKO) and CD4 (4B12), CD57 (NK-1), and granzyme B (11F1) (Novocastra, now part of Leica Microsystems, Wetzlar, Germany) ...
Immunotoxin resistance in multidrug resistant cells
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Howell Stephen B. et al., In Cancer Chemotherapy and Pharmacology, 2002
... Rabbit anti-His polyclonal antibody, mouse anti-human granzyme B monoclonal antibody, and rabbit polyclonal anti-LHR antibody were purchased from Santa Cruz Biotechnology, Inc ...
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Papers on granzyme B
Targeted Intracellular Protein Delivery Based on Hyaluronic Acid-Green Tea Catechin Nanogels.
New
Kurisawa et al., Singapore, Singapore. In Acta Biomater, Feb 2016
UNASSIGNED: A novel ternary nanogel based on the self-assembly of hyaluronic acid (HA)-(-)-epigallocatechin gallate (EGCG) conjugates, linear polyethylenimine (PEI) and Granzyme B (GzmB) in aqueous environment was developed for the targeted intracellular delivery of GzmB into cancer cells.
Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.
New
Qing et al., Torrance, United States. In Exp Mol Pathol, Feb 2016
By immunohistochemistry, the lymphoma cells expressed CD2, CD3, CD8, CD30, CD43, CD45, granzyme B, TIA-1, and negative for CD4, CD5, CD7, CD56, βF1, ALK-1, and B-cell markers.
Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma.
New
AMAZES Study Research Group et al., Adelaide, Australia. In Clin Exp Allergy, Jan 2016
We applied flow cytometry to measure T, CD28null, NK and NKT-like cells and their expression of granzyme B, perforin, and killer inhibitory/activating receptors CD94(Kp43), CD158b and CD107A.
Enhanced cytotoxic T-cell function and inhibition of tumor progression by Mst1 deficiency.
New
Kinashi et al., Ōsaka, Japan. In Febs Lett, Jan 2016
Mst1(-/-) cytotoxic T cells also exhibited enhanced T-bet expression that was associated with elevated expression levels of IFNγ and granzyme B.
Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney.
Review
New
Gohh et al., Providence, United States. In World J Transplant, Jan 2016
We review the literature on urinary biomarkers here, focusing on specific markers perforin and granzyme B mRNAs, FOXP3 mRNA, CXCL9/CXCL10 and miRNAs.
Prediction of T Cell Epitopes from Leishmania major Potentially Excreted/Secreted Proteins Inducing Granzyme B Production.
New
Louzir et al., Tunisia. In Plos One, Dec 2015
Six peptides were identified according to their ability to elicit production of granzyme B. Furthermore, among these peptides 3 showed highest affinity to HLA-A*0201, one derived from an elongation factor 1-alpha and two from an unknown protein.
Molecular characterization of HCMV-specific immune responses: Parallels between CD8(+) T cells, CD4(+) T cells, and NK cells.
Review
New
van Gisbergen et al., Amsterdam, Netherlands. In Eur J Immunol, Sep 2015
These HCMV-specific CD8(+) T cells maintain high levels of cytotoxic molecules such as granzyme B and rapidly produce the inflammatory cytokine IFN-γ upon activation.
Monitoring the acute response in severe hypersensitivity reactions to drugs.
Review
New
Aoyama et al., Okayama, Japan. In Curr Opin Allergy Clin Immunol, Aug 2015
RECENT FINDINGS: Although previous studies demonstrated the pathogenic role of TNF-α, IFN-γ, IL-10, perforin/granzyme B, Fas L and granulysin in the development of severe ADRs, there have been no biomarkers predicting progression to severe ADRs.
Primary Esophageal Extranasal NK/T Cell Lymphoma With Biphasic Morphology: A Case Report and Literature Review.
Review
New
Chen et al., Birmingham, United States. In Medicine (baltimore), Jul 2015
Immunohistochemical studies confirmed that both underlying atypical cells and superficial small lymphocytes were neoplastic, sharing an identical immunophenotype: positive for CD2, CD3, CD43, CD8, CD56, TIA-1 and granzyme B. Epstein-Barr virus-encoded small RNAs were found in both cells.
Quiescence of Memory CD8(+) T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4.
New
Impact
Sarkar et al., United States. In Immunity, Jul 2015
Loss of Treg cells resulted in activation of genome-wide transcriptional programs characteristic of effector T cells and drove transitioning as well as established memory CD8(+) T cells toward terminally differentiated KLRG-1(hi)IL-7Rα(lo)GzmB(hi) phenotype, with compromised metabolic fitness, longevity, polyfunctionality, and protective efficacy.
A Swiss Army knife for CTLs.
Impact
Weigelin et al., Houston, United States. In Immunity, 2015
Granzyme B released by leukocytes cleaves multiple intracellular substrates required for target cell lysis.
Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling.
Impact
Bird et al., Melbourne, Australia. In Immunity, 2015
Granzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes.
Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review.
Review
Alhumidi, Riyadh, Saudi Arabia. In Diagn Pathol, 2014
A skin biopsy revealed intravascular lymphoma (IVL) with a NK/T cell phenotype (positive for CD3, and granzyme B and negative for CD20, CD4, CD8, CD5).
Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.
Impact
Lieberman et al., Boston, United States. In Cell, 2014
Bacteria overexpressing a GzmB-uncleavable mutant of the complex I subunit nuoF or strains that lack complex I still die, but more slowly, suggesting that granzymes disrupt multiple vital bacterial pathways.
The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.
Impact
Haining et al., Philadelphia, United States. In Nat Immunol, 2014
BATF, together with the transcription factors IRF4 and Jun proteins, bound to and promoted early expression of genes encoding lineage-specific transcription-factors (T-bet and Blimp-1) and cytokine receptors while paradoxically repressing genes encoding effector molecules (IFN-γ and granzyme B).
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
GeneRIF
Openshaw et al., London, United Kingdom. In Mucosal Immunol, 2012
expression by regulatory t-cells controls lung inflammation during acute viral infection
Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria.
GeneRIF
Engwerda et al., Brisbane, Australia. In J Immunol, 2011
Data suggest that an interdependent relationship between parasite burden and CD8(+) T cells dictates the onset of perforin/GzmB-mediated ECM.
Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice.
GeneRIF
Granville et al., Vancouver, Canada. In Exp Gerontol, 2011
There is a role for Granzyme B in age-related skin thinning and frailty.
Cutting edge: persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status.
GeneRIF
Berger et al., Philadelphia, United States. In J Immunol, 2011
During lymphocytic choriomeningitis virus infection, despite persistent similarities in chromatin of CD8-positive memory cells, continuous transcription does not occur at the granzyme B locus.
A novel and divergent role of granzyme A and B in resistance to helminth infection.
GeneRIF
Korten et al., Hamburg, Germany. In J Immunol, 2011
GzmA/B deficiency in filarial infection is associated with a defense-promoting Th2 cytokine and antibody shift, enhanced early inflammatory gene expression, and a trend of reduced alternatively activated macrophage induction.
More papers using granzyme B antibodies
The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation
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Griffiths Gillian M. et al., In The Journal of Cell Biology, 2002
... ), granzyme B (C-19; Santa Cruz Biotechnology, Inc.), and CD3 (2C11; ...
Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle
Supplier
Henkart Pierre A. et al., In The Journal of Cell Biology, 2000
... The sources of other antibodies were as follows: anti–mouse CTLA-4 (R&D Systems); antiperforin KM585 (Kamaya); anti-granzyme B (Santa Cruz Biotechnology, Inc.); anti-Rab27a (Signal Transduction ...
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